Results 91 to 100 of about 11,802,626 (213)
ELO-Mask: Effective and Layerwise Optimization of Mask for Sparse LLMs
IEEE AccessTo address the issue of the substantial computational resource consumption during the inference phase of large language models due to their vast number of parameters, model sparsification is an effective solution.
Bingjie Xiang +7 more
doaj +1 more source
Discerning protein pools by selective staining with self‐labeling tags
FEBS Letters, EarlyView.Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Small Farm Quarterly - Fall 2014 [PDF]
, 2014 Small Farm Quarterly is for farmers and farm families — including spouses and children - who value the quality of life that smaller farms provide. OUR GOALS ARE TO: Celebrate the Northeast region’s smaller farms; Inspire and inform farm families and
Cornell Small Farms Program
core +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
IEEE AccessMechanical equipment functioning in intricate surroundings is prone to malfunctions, which can lead to accidents and significant financial losses. A key component of machinery health management, fault diagnosis creates a connection between equipment ...
Ouyang Chengda, Noramalina Abdullah
doaj +1 more source
Cotton Fusarium wilt diagnosis based on generative adversarial networks in small samples. [PDF]
Front Plant Sci, 2023 Zhang Z +6 more
europepmc +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
The Dangers of Small Samples and Insufficient Methodological Detail. [PDF]
Schizophr Bull, 2023 Barch DM.
europepmc +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source