Results 161 to 170 of about 8,511,971 (350)

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

FEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom, Jaewoong Jang, Jung Sun Park, Yong‐Kook Kang   +3 more
wiley   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

PP 5.5 – 00026 Targeting Tat/TAR interactions with the superelongation complex for the development of novel treatments for HIV/AIDS

Journal of Virus Eradication, 2022
U. Schulze-Gahmen, T. Divita, P. Kandel, M. Arkin, M. Ott   +4 more
doaj   +1 more source

Combining market surveys and participatory approaches to map small ruminant mobility in three selected states in northern Nigeria [PDF]

Sandra I. Ijoma, Asma Mesdour, Muhammad-Bashir Bolajoko, Chika Nwosuh, Marion Bordier, Arnaud Bataille, Abdulrahman Adeiza, Wesley. D. Nafarnda, Elena Arsevska, Andrea Apolloni   +9 more
openalex   +1 more source

The crystal structure of heme d ₁ biosynthesis-associated small c-type cytochrome NirC reveals mixed oligomeric states in crystallo [PDF]

, 2020
Thomas Klünemann, S. Henke, Wulf Blankenfeldt   +2 more
openalex   +1 more source

Small Gene Networks Delineate Immune Cell States and Characterize Immunotherapy Response in Melanoma [PDF]

, 2023
Donagh Egan, Martina Kreileder, Myriam Nabhan, Luis F. Iglesias‐Martinez, Simon J. Dovedi, Viia Valge-Archer, Amit Grover, Robert W. Wilkinson, Timothy Slidel, Claus Bendtsen, Ian P. Barrett, Donal J. Brennan, Walter Kölch, Vadim Zhernovkov   +13 more
openalex   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Climate Change Adaptation on Small Island States: An Assessment of Limits and Constraints [PDF]

, 2021
Walter Leal Filho, Murukesan V. Krishnapillai, Henry Sidsaph, Gustavo J. Nagy, Johannes M. Luetz, Jack Dyer, Michael Otoara Ha’apio, Peni Hausia Havea, Kushaal Raj, Priyatma Singh, T. G. Rogers, Chunlan Li, Monica K. Boodhan, Franziska Wolf, Desalegn Yayeh Ayal, Hossein Azadi   +15 more
openalex   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source