Results 191 to 200 of about 8,511,971 (350)

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Bridging the gap: a review of the factors contributing to differences in vaccination coverage among rural and urban adults. [PDF]

Vaccine
Granade C, Lindley M, Nelson J, Asif A, Zajac J, Reed X.   +5 more
europepmc   +1 more source

Small Business Survival Index Traction And Movement In Rankings Of States (2000-2013)

, 2014
P. K. Shukla, Monica Shukla
openalex   +2 more sources

X-ray Crystal Structures of the Estrogen-related Receptor-γ Ligand Binding Domain in Three Functional States Reveal the Molecular Basis of Small Molecule Regulation [PDF]

, 2006
Liping Wang, William J. Zuercher, Thomas G. Consler, Millard H. Lambert, Aaron B. Miller, Lisa A. Orband‐Miller, David D. McKee, Timothy M. Willson, Robert T. Nolte   +8 more
openalex   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Abdominal tuberculosis presenting as a massive lower GI bleed in a cerebral palsy patient-a case report. [PDF]

J Surg Case Rep
Kravets AM, Dkhillon D, Gross Z, Chernyak SB, Tarasov E.   +4 more
europepmc   +1 more source

Learning from Small States for Post-2015 Educational and International Development

, 2012
Michael Crossley, Terra Sprague
openalex   +2 more sources

Exploring Firm-Level Innovation and Productivity in Developing Countries: The Perspective of Caribbean Small States [PDF]

, 2017
Gustavo Crespi, Sylvia Döhnert, Alessandro Maffioli, Antônio Marcos Höelz Pinto Ambrózio, Manuel Barron, Federico Bernini, Lucas Figal Garone, Kayla Grant, Preeya Mohan, Diego Morris, Andrea Presbitero, Roberta Rabellotti, Filipe Lage de Sousa, Eric Strobl, Patrick Kent Watson   +14 more
openalex   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

Localized environmental governance for carbon dioxide removal in small island developing states: Challenges and opportunities

Dandan Yu, Zeyun Li, Sajid Hussain
openalex   +1 more source