Results 201 to 210 of about 2,346,393 (314)

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Advancing the design of the kissing bug kill trap for surveillance of triatomines. [PDF]

PLoS Negl Trop Dis
Tian Y, Fernández-Santos NA, Juarez JG, Esquivel H, Moller-Vasquez AM, Granados-Presa M, Echeverria A, Pennington P, Zamora-Jerez A, Fimbres-Macias JP, Roachell W, Lenhart PA, Casey T, Keck ME, Hodo CL, Downs CH, Sittenauer SC, Nevins CC, Balasubramanian S, Angulo C, Palacios-Cardiel C, Gaxiola-Robles R, Zenteno-Savín T, Hamer SA, Borden JH, Banfield MG, Padilla N, Hamer GL.   +27 more
europepmc   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

What is new on the horizon for the biologics world: New kids of the block - WAO state of art. [PDF]

World Allergy Organ J
Canonica GW, Ortega-Martell JA, Villarreal-González RV, Ansotegui IJ, Bachert C, Bernstein J, Bleecker E, Bondi B, Caminati M, Carr T, Cianferoni A, González ID, Díaz SG, Gómez RM, Hanania N, Heffler E, Nair P, Öztop N, Park HS, Pitè H, Rouadi P, Saito H, Triggiani M, Varricchi G, Virchow C, Yamada Y, Yáñez A, Morais-Almeida M.   +27 more
europepmc   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Phase Space Electronic Structure Theory: From Diatomic Lambda-Doubling to Macroscopic Einstein-de Haas. [PDF]

J Phys Chem Lett
Peng L, Qiu T, Bradbury N, Bian X, Bhati M, Littlejohn R, Kidwell NM, Subotnik JE.   +7 more
europepmc   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

A Method for the Analysis of the Symmetry of Excited States from GW-BSE. [PDF]

Int J Mol Sci
Maymoun M, Alrahamneh MJ, Saccomani A, Tolbatov I, Umari P.   +4 more
europepmc   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Laparoscopic repair of internal hernia in pregnant women after Roux-en-Y gastric bypass surgery: a case report. [PDF]

J Surg Case Rep
Farran AE, Thomason RK, Koller Gorham JS.   +2 more
europepmc   +1 more source