Results 111 to 120 of about 9,368,108 (292)

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Open Source Laser Polymer Welding System: Design and Characterization of Linear Low-Density Polyethylene Multilayer Welds

Machines, 2016
The use of lasers to weld polymer sheets provides a means of highly-adaptive and custom additive manufacturing for a wide array of industrial, medical, and end user/consumer applications.
John J. Laureto, Serguei V. Dessiatoun, Michael M. Ohadi, Joshua M. Pearce   +3 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Realising Grounded Design in practice: reflections on using Design Case Studies for practice-centred computing

i-com
It is well-known that moving from the rich kind of qualitative data generated in in-depth qualitative studies predicated on ethnographic approaches to actual design, a core aspect of Grounded Design (GD), is challenging. Although there have been a number
Pinatti de Carvalho Aparecido Fabiano, Abele Nils Darwin, Hoffmann Sven, Schweitzer Marcus, Tolmie Peter   +4 more
doaj   +1 more source

Fecal supernatants from dogs with idiopathic epilepsy activate enteric neurons

Frontiers in Neuroscience
IntroductionAlterations in the composition and function of the gut microbiome have been reported in idiopathic epilepsy (IE), however, interactions of gut microbes with the enteric nervous system (ENS) in this context require further study.
Kristin Elfers, Antja Watanangura, Antja Watanangura, Antja Watanangura, Pascal Hoffmann, Jan S. Suchodolski, Mohammad R. Khattab, Rachel Pilla, Sebastian Meller, Holger A. Volk, Holger A. Volk, Gemma Mazzuoli-Weber, Gemma Mazzuoli-Weber   +12 more
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Behavioral comorbidities treatment by fecal microbiota transplantation in canine epilepsy: a pilot study of a novel therapeutic approach

Frontiers in Veterinary Science
IntroductionAnxiety and cognitive dysfunction are frequent, difficult to treat and burdensome comorbidities in human and canine epilepsy. Fecal microbiota transplantation (FMT) has been shown to modulate behavior in rodent models by altering the ...
Antja Watanangura, Antja Watanangura, Antja Watanangura, Sebastian Meller, Nareed Farhat, Jan S. Suchodolski, Rachel Pilla, Mohammad R. Khattab, Bruna C. Lopes, Andrea Bathen-Nöthen, Andrea Fischer, Kathrin Busch-Hahn, Cornelia Flieshardt, Martina Gramer, Franziska Richter, Franziska Richter, Anna Zamansky, Holger A. Volk, Holger A. Volk   +18 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Climate change perspectives of coffee farmers in Junín Mountain tropical forests and CMIP5 projections

Frontiers in Climate
BackgroundClimate change poses a remarkable challenge for farmers due to its profound impact on ecosystems. Certain crops, such as coffee, are particularly sensitive. In Peru, global climate models project increasing temperatures, shifts in precipitation
Alexis Nicolás Ibáñez-Blancas, Alexis Nicolás Ibáñez-Blancas, Alexis Nicolás Ibáñez-Blancas, José Miguel Sánchez-Uzcátegui, Zoila Aurora Cruz-Burga, Zoila Aurora Cruz-Burga, Zoila Aurora Cruz-Burga, Julio Alberto Chávez-Achong, Julio Alberto Chávez-Achong, Julio Alberto Chávez-Achong   +9 more
doaj   +1 more source