Results 51 to 60 of about 10,367,950 (284)
Targeting RNA structures with small molecules
Nature Reviews Drug Discovery, 2022 RNA adopts 3D structures that confer varied functional roles in human biology and dysfunction in disease. Approaches to therapeutically target RNA structures with small molecules are being actively pursued, aided by key advances in the field including the development of computational tools that predict evolutionarily conserved RNA structures, as well ...
Jessica L. Childs-Disney +5 more
openaire +2 more sources
Pediatric Blood &Cancer, EarlyView.ABSTRACT Purpose Next‐generation sequencing (NGS) has emerged as a promising approach to improve diagnostic accuracy, but its feasibility in low‐ and middle‐income countries remains unknown. This study characterized the diagnostic landscape and assessed organizational readiness for NGS implementation at two childhood cancer treatment centers in Accra ...
Melissa Carvalho +6 more
wiley +1 more source
Wampee-YOLO: A High-Precision Detection Model for Dense Clustered Wampee in Natural Orchard Scenario
HorticulturaeWampee (Clausena lansium) harvesting currently relies heavily on manual labor, but automation is significantly hindered by clustered fruit growth patterns, small fruit sizes, and complex orchard backgrounds, which make accurate detection highly ...
Zhiwei Li +7 more
doaj +1 more source
Sensors, 2014 This paper presents a region-adaptive clutter rejection method for small target detection in sea-based infrared search and track. In the real world, clutter normally generates many false detections that impede the deployment of such detection systems ...
Sungho Kim, Joohyoung Lee
doaj +1 more source
Small Ship Detection Based on Improved Neural Network Algorithm and SAR Images
Remote SensingSynthetic aperture radar images can be used for ship target detection. However, due to the unclear ship outline in SAR images, noise and land background factors affect the difficulty and accuracy of ship (especially small target ship) detection ...
Jiaqi Li +6 more
doaj +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Survivorship care plans (SCPs) summarize cancer treatment and guide risk‐based follow‐up for cancer survivors, yet remain difficult to create, share, and use. Stakeholder perspectives are needed to inform usable approaches.
Molly S. Talman +4 more
wiley +1 more source
Image-Level Anti-Personnel Landmine Detection Using Deep Learning in Long-Wave Infrared Images
Applied SciencesThis study proposes a simple deep learning-based framework for image-level anti-personnel landmine detection in long-wave infrared imagery. To address challenges posed by the limited size of the available dataset and the small spatial size of anti ...
Jun-Hyung Kim, Goo-Rak Kwon
doaj +1 more source
Small-Molecule Targets in Tumor Immunotherapy [PDF]
Natural Products and Bioprospecting, 2018 Cancer immunotherapy has been widely recognized as a powerful approach to fight cancers. To date, over 50 phase III trials in cancer immunotherapy are in progress. Among the many immunotherapy approaches, immune checkpoint therapy has attracted considerable attention.
Hui-Fang Zhu, Yan Li
openaire +3 more sources
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Children with sickle cell anemia (SCA) in low‐income settings are at risk of severe malnutrition, but optimal nutritional management has not been established. We evaluated an intensified ready‐to‐use therapeutic food (RUTF) regimen in children with persistent severe malnutrition after initial treatment and assessed whether early ...
Safiya Gambo +9 more
wiley +1 more source
AgricultureIn the field of smart plant protection, accurate early monitoring of winged aphids is critical, as it enables the interruption of viral disease transmission and reduces dependence on pesticides.
Bolun Guan +5 more
doaj +1 more source