Results 81 to 90 of about 10,367,950 (284)

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

RMVAD-YOLO: A Robust Multi-View Aircraft Detection Model for Imbalanced and Similar Classes

Remote Sensing
Aircraft detection technology plays a vital role in civilian applications, with significant attention being devoted to research on related algorithms in recent years.
Keda Li, Xiangyue Zheng, Jingxin Bi, Gang Zhang, Yi Cui, Tao Lei   +5 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

EER-DETR: An Improved Method for Detecting Defects on the Surface of Solar Panels Based on RT-DETR

Applied Sciences
In the context of the rapid popularization of clean energy, the precise identification of surface defects on photovoltaic modules has become a core technical bottleneck limiting the operational efficiency of power stations.
Jiajun Dun, Hai Yang, Shixin Yuan, Ying Tang   +3 more
doaj   +1 more source

An automatic target detection algorithm based on wavelet analysis for infrared image small target in background of sea and sky

, 2003
An automatic target detection algorithm is developed for infrared image small target in complicate background of sea and sky. Wavelet multiresolution edge detection algorithm is adopted to detect the sea-level line from coarse to fine.
Shi ZL(史泽林), Yu HB(于海斌), Wei Y(魏颖)   +2 more
core  

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

SAGNet: Small-Target Attention Guided Network for Urban Remote Sensing Image Real-Time Segmentation

IEEE Access
High-precision real-time segmentation of urban remote sensing (URS) images is crucial for emergency response such as urban flood warning and fire spread monitoring.
Shasha Ren, Xiaodong Zhang
doaj   +1 more source