Results 181 to 190 of about 203,748 (298)

Regulation of PHOX2B gene expression by the long non‐coding natural antisense RNA PHOX2B‐AS1

The FEBS Journal, EarlyView.
PHOX2B is a transcription factor essential for autonomic nervous system development. We identify and characterize PHOX2B‐AS1, a human long non‐coding antisense transcript at the PHOX2B locus, along with its murine counterpart. Our findings reveal bidirectional transcription and reciprocal regulation: PHOX2B activates PHOX2B‐AS1, whereas PHOX2B‐AS1 ...
Simona Di Lascio, Ana Lucia Cuadros Gamboa, Martina Bertocchi, Filippo Chiesa, Francesca Cargnin, Ettore Mosca, Paride Pelucchi, Viviana Tritto, Stefania Corti, Isabella Ceccherini, Paola Riva, Roberta Benfante, Diego Fornasari   +12 more
wiley   +1 more source

Characterization of a cDNA clone for the nonspecific cross-reacting antigen (NCA) and a comparison of NCA and carcinoembryonic antigen [PDF]

, 1988
Hinoda, Yuji, Neumaier, Michael, Riggs, Arthur D., Shively, John E., Shively, Louise, Zimmermann, Wolfgang   +5 more
core  

GCN2 in proteostasis: structural logic, signalling networks and disease

The FEBS Journal, EarlyView.
Threats to protein synthesis activate the kinase GCN2, initiating the integrated stress response (ISR). GCN2 is triggered by stalled ribosomes and uncharged tRNAs, which accumulate when amino acids are scarce. The ISR adjusts cellular physiology by promoting redox balance, protein quality control, and mitochondrial optimisation.
JiaYi Zhu, Stefan J. Marciniak
wiley   +1 more source

Biological functions of tsRNAs and research advances in human disease. [PDF]

Biochem Biophys Rep
Jiang Y, Liu S, Li G, Tang C, Zhang Y, Li J, Tan Z, Zhang S, Chen Z, Li S.   +9 more
europepmc   +1 more source

Enhanced exonuclease–Cas9 systems promote multiple nucleotide deletions with higher efficiency and broader targeting scope in plants

Journal of Integrative Plant Biology, EarlyView.
Cas9 preferentially generates small indels. By tethering an exonuclease and a DNA‐binding domain (DBD) to Cas9, the Exo‐DBD‐Cas9 system efficiently promotes multiple nucleotide deletions. These expanded deletions enable effective disruption of miRNA‐mediated regulation and relieve translational repression through targeted editing of 3′ untranslated ...
Rui Zhang, Xu Tang, Yao He, Wei Wang, Qiurong Ren, Yiping Qi, Yong Zhang   +6 more
wiley   +1 more source

The molecular mechanism of IGF2BP3 promoting the malignant progression of lung cancer. [PDF]

Cancer Cell Int
Wu C, Ma Y, Li J, Hai B, Zhou Y, Cao F, Kang X, Xu X.   +7 more
europepmc   +1 more source

An algal Baeyer-Villiger monooxygenase is produced as an active enzyme in the cyanobacterium Synechocystis 6803 [PDF]

, 2017
Bergantino, Elisabetta
core  

OsFKBP20‐1b stabilizes OsUPF1 and OsUPF2 to promote the degradation of aberrant mRNAs during dehydration stress

Journal of Integrative Plant Biology, EarlyView.
The rice protein OsFKBP20‐1b protects key RNA‐surveillance factors from breakdown, so they can better eliminate defective messages. This RNA quality‐control boost reduces errors and helps plants survive drought, revealing a link between RNA control and drought tolerance.
Haemyeong Jung, Hyun Ji Park, Seung Hee Jo, Ki‐Hong Jung, Choonkyun Jung, Hye Sun Cho   +5 more
wiley   +1 more source

Bacterial EVs contain small RNAs and transfer RNAs that regulate inflammation in lung infections. [PDF]

Front Immunol
Charpentier LA, Stanton BA.
europepmc   +1 more source

3'untranslated regions (3'UTR) of Gelsolin mRNA displays anticancer effects in non-small cell lung cancer (NSCLC) cells.

, 2021
Xiaohui Liu, Xiuzhu Huang, Jie Ma, Lu Li, Huifan Hu, Junxia Feng, Xuejuan Gao, Yunfang Zhang, Langxia Liu   +8 more
openalex   +1 more source