Germline inherited small RNAs clear untranslated maternal mRNAs in C. elegans embryos [PDF]
, 2020 ABSTRACTInheritance and clearance of maternal mRNAs are two of the most critical events required for animal early embryonic development. However, the mechanisms regulating this process are still largely unknown. Here, we show that together with maternal mRNAs,C.
Piergiuseppe Quarato +7 more
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Supplementary Figure 1, Tables 1-4 from A SNP in a <i>let-7</i> microRNA Complementary Site in the <i>KRAS</i> 3′ Untranslated Region Increases Non–Small Cell Lung Cancer Risk [PDF]
, 2023 Supplementary Figure 1, Tables 1-4 from A SNP in a <i>let-7</i> microRNA Complementary Site in the <i>KRAS</i> 3′ Untranslated Region Increases Non–Small Cell Lung Cancer ...
Lena J. Chin +20 more
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Oncology Letters, 2023 Silencing XB130 inhibits cell proliferation and epithelial-mesenchymal transition in non-small cell lung cancer (NSCLC), suggesting that downregulating XB130 expression may impede NSCLC progression. However, the molecular mechanism underlying the regulation of XB130 expression remains unclear.
Qinrong Wang +8 more
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Migration of Small Ribosomal Subunits on the 5′ Untranslated Regions of Capped Messenger RNA [PDF]
International Journal of Molecular Sciences, 2019 Several control mechanisms of eukaryotic gene expression target the initiation step of mRNA translation. The canonical translation initiation pathway begins with cap-dependent attachment of the small ribosomal subunit (SSU) to the messenger ribonucleic acid (mRNA) followed by an energy-dependent, sequential ‘scanning’ of the 5′ untranslated regions ...
Nikolay E. Shirokikh +4 more
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Inhibition of hepatitis C virus IRES-mediated translation by small RNAs analogous to stem-loop structures of the 5'-untranslated region [PDF]
Nucleic Acids Research, 2004 Translation of the hepatitis C virus (HCV) RNA is mediated by the interaction of ribosomes and cellular proteins with an internal ribosome entry site (IRES) located within the 5'-untranslated region (5'-UTR). We have investigated whether small RNA molecules corresponding to the different stem-loop (SL) domains of the HCV IRES, when introduced in trans,
Partho Sarothi Ray
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Expression of the ISPpu9 transposase of Pseudomonas putida KT2440 is regulated by two small RNAs and the secondary structure of the mRNA 5′-untranslated region [PDF]
Nucleic Acids Research, 2021 Abstract Insertion sequences (ISs) are mobile genetic elements that only carry the information required for their own transposition. Pseudomonas putida KT2440, a model bacterium, has seven copies of an IS called ISPpu9 inserted into repetitive extragenic palindromic sequences. This work shows that the gene for ISPpu9 transposase, tnp, is
G. Esparza Gómez +4 more
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, 2023 <div>Abstract<p>Lung cancer is the leading cause of cancer deaths worldwide, yet few genetic markers of lung cancer risk useful for screening exist. The <i>let-7</i> family-of-microRNAs (miRNA) are global genetic regulators important in controlling lung cancer oncogene expression by binding to the 3′ untranslated regions of ...
Lena J. Chin +20 more
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West Nile virus encodes a microRNA-like small RNA in the 3' untranslated region which up-regulates GATA4 mRNA and facilitates virus replication in mosquito cells [PDF]
Nucleic Acids Research, 2011 West Nile virus (WNV) belongs to a group of medically important single-stranded, positive-sense RNA viruses causing deadly disease outbreaks around the world. The 3' untranslated region (3'-UTR) of the flavivirus genome, in particular the terminal 3' stem-loop (3'SL) fulfils multiple functions in virus replication and virus-host interactions. Using the
Mazhar Hussain +7 more
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A small yeast RNA selectively inhibits internal initiation of translation programmed by poliovirus RNA: specific interaction with cellular proteins that bind to the viral 5'-untranslated region [PDF]
Journal of Virology, 1994 We have purified, sequenced, and prepared a synthetic clone of a small (60-nucleotide) RNA molecule from the yeast Saccharomyces cerevisiae that had previously been isolated on the basis of its ability to selectively block the translation of poliovirus mRNA. RNA derived from the clone by transcription with T7 RNA polymerase appears to block translation
Saumitra Das +2 more
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Journal of Bacteriology, 2022 Salmonella enterica serovar Typhimurium is a prominent foodborne pathogen, infecting millions of people a year. To express virulence genes at the correct time and place in the host, Salmonella uses a complex regulatory network that senses environmental conditions.
Sabrina Z. Abdulla +6 more
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