Results 91 to 100 of about 1,168,068 (349)

DDX3X induces mesenchymal transition of endothelial cells by disrupting BMPR2 signaling

FEBS Open Bio, EarlyView.
Elevated DDX3X expression led to downregulation of BMPR2, a key regulator of endothelial homeostasis and function. Our co‐immunoprecipitation assays further demonstrated a molecular interaction between DDX3X and BMPR2. Notably, DDX3X promoted lysosomal degradation of BMPR2, thereby impairing its downstream signaling and facilitating endothelial‐to ...
Yu Zhang, Jing Wang, De‐Hui Qian, Yang‐Fan Lv, Tian‐Le Cheng, Da‐Peng Wang, Jing Zhang, Ye Fan   +7 more
wiley   +1 more source

The diagnostic performance of transcranial Doppler ultrasound and carotid duplex in the diagnosis of cerebral small vessel disease

The Egyptian Journal of Radiology and Nuclear Medicine
Background and rationale Cerebral small vessel disease is a frequent, long-term, and progressing vascular disease accounting for twenty percent of whole strokes and twenty-five percent of ischemic strokes.
Afaf Mohamed, Sara Gamal, Sama Ayman, Hatem El-Azizi   +3 more
doaj   +1 more source

Cognitive impairment in sporadic cerebral small vessel disease: A systematic review and meta‐analysis

Alzheimer's & Dementia, 2020
This paper is a proposal for an update on the characterization of cognitive impairments associated with sporadic cerebral small vessel disease (SVD). We pose a series of questions about the nature of SVD‐related cognitive impairments and provide answers ...
Olivia K. L. Hamilton, E. Backhouse, Esther Janssen, A. Jochems, Caragh Maher, Tuula E Ritakari, A. Stevenson, Lihua Xia, I. Deary, J. Wardlaw   +9 more
semanticscholar   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Neuroimaging standards for research into small vessel disease—advances since 2013

Lancet Neurology, 2023
Marco Duering, G. Biessels, A. Brodtmann, Christopher P L H Chen, C. Cordonnier, F.‐E. Leeuw, S. Debette, R. Frayne, E. Jouvent, N. Rost, A. Telgte, R. Salman, W. Backes, H. Bae, Rosalind Brown, H. Chabriat, A. Luca, C. DeCarli, Anna Dewenter, F. Doubal, M. Ewers, T. Field, A. Ganesh, S. Greenberg, K. Helmer, S. Hilal, A. Jochems, H. Jokinen, Hugo J. Kuijf, B. Lam, J. Lebenberg, B. MacIntosh, P. Maillard, Vincent C. T. Mok, L. Pantoni, S. Rudilosso, C. Satizabal, M. Schirmer, R. Schmidt, Colin Smith, J. Staals, M. Thrippleton, S. V. Veluw, P. Vemuri, Yilong Wang, D. Werring, M. Zedde, R. Akinyemi, O. Brutto, H. Markus, Yi-cheng Zhu, E. Smith, M. Dichgans, J. Wardlaw   +53 more
semanticscholar   +1 more source

Lesion Location and Functional Connections Reveal Cognitive Impairment Networks in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Cognitive impairment, fatigue, and depression are common in multiple sclerosis (MS), potentially due to disruption of regional functional connectivity caused by white matter (WM) lesions. We explored whether WM lesions functionally connected to specific brain regions contribute to these MS‐related manifestations.
Alessandro Franceschini, Paolo Preziosa, Paola Valsasina, Damiano Mistri, Monica Margoni, Federica Esposito, Massimo Filippi, Maria A. Rocca   +7 more
wiley   +1 more source

SNUPN‐Related Muscular Dystrophy: Novel Phenotypic, Pathological and Functional Protein Insights

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective SNUPN‐related muscular dystrophy or LGMDR29 is a new entity that covers from a congenital or childhood onset pure muscular dystrophy to more complex phenotypes combining neurodevelopmental features, cataracts, or spinocerebellar ataxia. So far, 12 different variants have been described.
Nuria Muelas, Pablo Iruzubieta, Alberto Damborenea, Laura Pérez‐Fernández, Inmaculada Azorín, Juan Carlos Jiménez García, Ana Töpf, Pilar Martí, Lorena Fores‐Toribio, María Manterola, Rosana Blanco‐Mañez, Oihane Pikatza‐Menoio, Sonia Alonso‐Martín, Volker Straub, Aitziber L. Cortajarena, Adolfo López de Munain, David De Sancho, Lorea Blázquez, Juan J. Vilchez   +18 more
wiley   +1 more source

Impact of APOE ε4 Genotype Load on Cognitive Function and Lipid Metabolism in Patients With Cerebral Small Vessel Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Apolipoprotein ε4 (APOE ε4) is a potent genetic risk factor for Alzheimer's disease (AD). However, its role in cerebral small vessel disease (CSVD) remains unclear. Given the clinical and pathological similarities between CSVD and AD, this study aimed to investigate the associations of APOE ε4 gene dosage with cognitive function and
Tingru Jin, Haocheng Yang, Feng Liu, Sihao Lin, Junru Hu, Jian Wang, Yulan Gou   +6 more
wiley   +1 more source

Small Brain Vessels Disease [PDF]

Biomedical Journal of Scientific & Technical Research, 2019
Small vessel disease is a disorder of the small perforating arterioles, capillaries and probably cerebral venules, which causes various lesions that can be observed in the anatomopathological examination, Magnetic Resonance Imaging (MRI) or Computerized Tomography (CT) of the ...
openaire   +1 more source

Copy Number Variants and Their Association With Intracerebral Hemorrhage Risk: A Case–Control Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Intracerebral Hemorrhage (ICH) is a leading cause of morbidity and mortality worldwide and lacks effective therapeutic interventions. Despite previous studies, the genetic underpinnings of ICH remain poorly understood. We sought to investigate the role of copy number variants (CNVs) in ICH pathophysiology to identify novel ...
Savvina Prapiadou, Carl D. Langefeld, Padmini Sekar, Mary Comeau, Timothy Howard, Tamara N. Kimball, Chen Bowang, Hyacinth I. Hyacinth, Jonathan Rosand, Christopher D. Anderson, Caspar Grond‐Ginsbach, Daniel Woo, Stacie L. Demel   +12 more
wiley   +1 more source