Results 91 to 100 of about 1,601,455 (409)

An unusual case of isolated symmetric bilateral peripheral artery disease of the radial artery of the index finger in systemic sclerosis: A case report and literature review

Journal of the Practice of Cardiovascular Sciences, 2022
We report an extremely rare and peculiar case of symmetric peripheral small-vessel disease involving only the radial artery of the index finger sparing major vessels in an 80-year-old female with systemic sclerosis (SSc). Our case is the first literature
Debasish Das, Anindya Banerjee, Abhinav Kumar, Shashikant Singh, Subhas Pramanik   +4 more
doaj   +1 more source

Small vessel disease and biomarkers of endothelial dysfunction after ischaemic stroke [PDF]

, 2018
Introduction: Although pathogenesis of small vessel disease is poorly understood, increasing evidence suggests that endothelial dysfunction may have a relevant role in development and progression of small vessel disease.
Abbate, Rosanna, Arba, Francesco, Biagini, Silvia, Bono, Giorgio, Bovi, Paolo, Consoli, Domenico, Fainardi, Enrico, Giannini, Alessio, Giusti, Betti, Inzitari, Domenico, Maria Gori, Anna, Massaro, Francesca, Nencini, Patrizia, Nesi, Mascia, Nucera, Antonia, Orlandi, Giovanni, Palumbo, Vanessa, Perini, Francesco, Piccardi, Benedetta, Pracucci, Giovanni, Sessa, Maria, Tassi, Rossana, Toni, Danilo   +22 more
core   +2 more sources

Simultaneous inhibition of TRIM24 and TRIM28 sensitises prostate cancer cells to antiandrogen therapy, decreasing VEGF signalling and angiogenesis

Molecular Oncology, EarlyView.
TRIM24 and TRIM28 are androgen receptor (AR) coregulators which exhibit increased expression with cancer progression. Both TRIM24 and TRIM28 combine to influence the response of castrate‐resistant prostate cancer (CRPC) cells to AR inhibitors by mediating AR signalling, regulation of MYC and upregulating VEGF to promote angiogenesis. Castrate‐resistant
Damien A. Leach, Nilesh Chatterjee, Kellie Spahr, Gilberto Serrano de Almeida, Anabel Varela‐Carver, Taimur T. Shah, Mathias Winkler, Hashim U. Ahmed, Charlotte L. Bevan   +8 more
wiley   +1 more source

Deep 3D Vessel Segmentation based on Cross Transformer Network [PDF]

arXiv, 2022
The coronary microvascular disease poses a great threat to human health. Computer-aided analysis/diagnosis systems help physicians intervene in the disease at early stages, where 3D vessel segmentation is a fundamental step. However, there is a lack of carefully annotated dataset to support algorithm development and evaluation.
arxiv  

Longitudinal patterns of leukoaraiosis and brain atrophy in symptomatic small vessel disease. [PDF]

, 2016
Cerebral small vessel disease is a common condition associated with lacunar stroke, cognitive impairment and significant functional morbidity. White matter hyperintensities and brain atrophy, seen on magnetic resonance imaging, are correlated with ...
Andrew J. Lawrence, Ashburner, Christian Lambert, Curnes, Eva Zeestraten, Hugh S. Markus, Kraha, Philip Benjamin, Thomas R. Barrick, Wender   +9 more
core   +1 more source

Early life predictors of late life cerebral small vessel disease in four prospective cohort studies

Brain : a journal of neurology, 2021
Development of cerebral small vessel disease, a major cause of stroke and dementia, may be influenced by early life factors. It is unclear whether these relationships are independent of each other, of adult socio-economic status or of vascular risk ...
E. Backhouse, S. Shenkin, A. McIntosh, M. Bastin, H. Whalley, Maria Valdez Hernandez, S. Muñoz Maniega, M. Harris, A. Stolicyn, A. Campbell, D. Steele, G. Waiter, Anca-Larisa Sandu, J. Waymont, A. Murray, S. Cox, S. D. de Rooij, T. Roseboom, J. Wardlaw   +18 more
semanticscholar   +1 more source

Understanding and measuring mechanical signals in the tumor stroma

FEBS Open Bio, EarlyView.
This review discusses cancer‐associated fibroblast subtypes and their functions, particularly in relation to extracellular matrix production, as well as the development of 3D models to study tumor stroma mechanics in vitro. Several quantitative techniques to measure tissue mechanical properties are also described, to emphasize the diagnostic and ...
Fàtima de la Jara Ortiz, Chiara Cimmino, Maurizio Ventre, Alessandra Cambi   +3 more
wiley   +1 more source

Cerebral small vessel disease and Alzheimer’s disease

Clinical Interventions in Aging, 2015
Zhiyou Cai,1 Chuanling Wang,1 Wenbo He,1 Hanjun Tu,2 Zhengang Tang,3 Ming Xiao,4 Liang-Jun Yan51Department of Neurology, Renmin Hospital, Hubei University of Medicine, 2Department of Basic Research Center, Hubei University of Medicine, 3Department of ...
Cai Z, Wang C, He W, Tu H, Tang Z, Xiao M, Yan LJ   +6 more
doaj  

Blood-brain barrier pathology in cerebral small vessel disease

Neural Regeneration Research
Cerebral small vessel disease is a neurological disease that affects the brain microvasculature and which is commonly observed among the elderly. Although at first it was considered innocuous, small vessel disease is nowadays regarded as one of the major
Ruxue Jia, Gemma Solé-Guardia, Amanda J Kiliaan   +2 more
doaj   +1 more source

Population Imaging of Cerebral Small Vessel Disease [PDF]

, 2012
As we grow older, our brain tends to shrink. We become increasingly vul nerable to dementia and stroke, two common disorders in the elderly that have great impact on brain functioning and the way people live their lives.
Poels, M.M.F. (Mariëlle)
core   +1 more source