Results 121 to 130 of about 1,382,769 (383)

Matrix: a complex amalgam of structures and functions in tumor microenvironment

FEBS Open Bio, EarlyView.
The matrix is a dynamic, intricate three‐dimensional mesh of biomolecules with both structural and functional properties. This review deals with the complexity of this ‘molecular amalgam’ in the tumor microenvironment and highlights its importance in the maintenance and evolution of tumors by describing certain matrix biomolecules, such as ...
Spyros S. Skandalis, Evgenia Tsoukala, Theodora D. Sarantopoulou, Maria‐Elpida Christopoulou   +3 more
wiley   +1 more source

The edge visualization metric: Quantifying the improvement of lung SBRT target definition with 4D CBCT

Journal of Applied Clinical Medical Physics, EarlyView.
Abstract Purpose Four‐dimensional cone‐beam CT (4D CBCT) incorporates oversampling of 3D data to reconstruct multi‐phase CBCT data sets representing distinct phases of the breathing cycle based on a diaphragmatic correlate of respiratory motion. Motion artifacts and blurring can be reduced relative to three‐dimensional cone‐beam (3D CBCT), allowing ...
Colton Baley, Sam Andersen, Clark Anderson, Shraddha Dalwadi, Daniel L. Saenz   +4 more
wiley   +1 more source

Contributions of Aging to Cerebral Small Vessel Disease.

Annual Review of Physiology, 2020
Cerebral small vessel disease (SVD) is characterized by changes in the pial and parenchymal microcirculations. SVD produces reductions in cerebral blood flow and impaired blood-brain barrier function, which are leading contributors to age-related ...
T. D. De Silva, F. Faraci
semanticscholar   +1 more source

The Brief Memory and Executive Test (BMET) for detecting vascular cognitive impairment in small vessel disease: a validation study. [PDF]

, 2016
Cognitive impairment is common in patients with cerebral small vessel disease, but is not well detected using common cognitive screening tests which have been primarily devised for cortical dementias.
Brookes, RL, Hollocks, MJ, Khan, U, Markus, HS, Morris, RG   +4 more
core   +1 more source

Serotonergic and Dopaminergic Function in Neuropsychiatrically Asymptomatic People With HIV on Antiretroviral Therapy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective People with HIV (PWH) on antiretroviral therapy (ART) still experience neurocognitive dysfunction and accelerated brain volume loss. To assess whether the serotonergic and dopaminergic systems are affected, we used [11C]DASB positron emission tomography (PET) to assess presynaptic serotonergic function and [18F]FDOPA PET to measure ...
Chuen‐Yen Lau, Anna Lyndaker, Swati Shah, Paul Wakim, Amelia Mitchell, Cynthia Monroe, Alan Kim, Tracy L. Cropper, Govind Nair, Joseph Snow, Bryan R. Smith, Avindra Nath, Dima A. Hammoud   +12 more
wiley   +1 more source

Simple MRI score aids prediction of dementia in cerebral small vessel disease

Neurology, 2020
Objective To determine whether a simple small vessel disease (SVD) score, which uses information available on rapid visual assessment of clinical MRI scans, predicts risk of cognitive decline and dementia, above that provided by simple clinical measures.
Ali Amin Al Olama, J. Wason, A. Tuladhar, Esther M C van Leijsen, M. Koini, E. Hofer, R. Morris, R. Schmidt, F. de Leeuw, H. Markus   +9 more
semanticscholar   +1 more source

Brain Characteristics in Patients With Myelin Oligodendrocyte Glycoprotein Antibody‐Associated Disorder by 7.0 Tesla MRI

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Myelin oligodendrocyte glycoprotein antibody‐associated disease (MOGAD) can radiographically mimic multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD). The disease hallmarks cortical lesion, central vein sign (CVS) and paramagnetic rim lesions identified in MS have not yet been comprehensively investigated in ...
Lei Su, Joseph Kuchling, Chenyang Gao, Thoralf Niendorf, Carsten Finke, Zhe Zhang, Ai Guo, Jing Jing, De‐Cai Tian, Yu‐Jing Li, Mengting Zhang, Xiaoyu Shi, Xinyao Liu, Huabing Wang, Yaou Liu, Claudia Chien, Michael Levy, Yunyun Duan, Friedemann Paul, Fu‐Dong Shi   +19 more
wiley   +1 more source

Neuroimaging standards for research into small vessel disease—advances since 2013

Lancet Neurology, 2023
M. Duering, G. Biessels, A. Brodtmann, Christopher P L H Chen, C. Cordonnier, F.‐E. Leeuw, S. Debette, R. Frayne, E. Jouvent, N. Rost, A. Telgte, R. Salman, W. Backes, H. Bae, Rosalind Brown, H. Chabriat, A. Luca, C. DeCarli, Anna Dewenter, F. Doubal, M. Ewers, T. Field, A. Ganesh, S. Greenberg, K. Helmer, S. Hilal, A. Jochems, H. Jokinen, Hugo J. Kuijf, B. Lam, J. Lebenberg, B. MacIntosh, P. Maillard, Vincent C. T. Mok, L. Pantoni, S. Rudilosso, C. Satizabal, M. Schirmer, R. Schmidt, Colin Smith, J. Staals, M. Thrippleton, S. V. Veluw, P. Vemuri, Yilong Wang, D. Werring, M. Zedde, R. Akinyemi, O. Brutto, H. Markus, Yicheng Zhu, E. Smith, M. Dichgans, J. Wardlaw   +53 more
semanticscholar   +1 more source

Accelerated development of cerebral small vessel disease in young stroke patients. [PDF]

, 2016
OBJECTIVE: To study the long-term prevalence of small vessel disease after young stroke and to compare this to healthy controls. METHODS: This prospective cohort study comprises 337 patients with an ischemic stroke or TIA, aged 18-50 years, without a ...
Arntz, Renate M, de Leeuw, Frank-Erik, Ghafoorian, Mohsen, Maaijwee, Noortje AM, Platel, Bram, Rutten-Jacobs, Loes CA, Schaapsmeerders, Pauline, Schoonderwaldt, Hennie C, van den Broek, Steffen MA, van Dijk, Ewoud J, van Uden, Inge WM   +10 more
core   +2 more sources

Pulse Pressure, White Matter Hyperintensities, and Cognition: Mediating Effects Across the Adult Lifespan

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives To investigate whether pulse pressure or mean arterial pressure mediates the relationship between age and white matter hyperintensity load and to examine the mediating effect of white matter hyperintensities on cognition. Methods Demographic information, blood pressure, current medication lists, and Montreal Cognitive Assessment ...
Jade Hannan, Sarah Newman‐Norlund, Natalie Busby, Sarah C. Wilson, Roger Newman‐Norlund, Chris Rorden, Julius Fridriksson, Leonardo Bonilha, Nicholas Riccardi   +8 more
wiley   +1 more source