Results 131 to 140 of about 1,168,068 (349)

3D Multicellular Scaffold Based Model for Advancing Bone Disorder Research

Advanced Functional Materials, EarlyView.
A scalable 3D multicellular in vitro bone model engineered by integrating osteoblasts, osteoclasts, and endothelial cells on biodegradable scaffolds. The system recapitulates key features of human bone remodeling and disease pathology. As a proof of concept, the model mimics osteogenesis imperfecta, demonstrating its potential as a physiologically ...
Gali Guterman‐Ram, Majd Machour, Janette Zavin, Roy Meretzki, Reut Lev‐Ari, Shulamit Levenberg   +5 more
wiley   +1 more source

Associations between total MRI-visible small vessel disease burden and domain-specific cognitive abilities in a community-dwelling older-age cohort

, 2021
Olivia KL Hamilton, Simon R. Cox, Lucia Ballerini, ME Bastin, Janie Corley, Alan J. Gow, Susana Muñoz Maniega, Paul Redmond, María del C. Valdés Hernández, Joanna M. Wardlaw, Ian J. Deary   +10 more
openalex   +1 more source

Neurofilament Light and mean Free Water as prognostic enrichment biomarkers for cognitive worsening and small vessel disease progression [PDF]

, 2023
Pauline Maillard, Alexa Beiser, Mohamad Habes, Russell P. Tracy, Tiffany F. Kautz, Amy R. Saklad, Pia Kivisäkk, Hanzhang Lu, Konstantinos Arfanakis, Brian T. Gold, Joel H. Kramer, Danny J.J. Wang, Gary A. Rosenberg, Herpreet Singh, Kristin Schwab, Karl G. Helmer, Steven M. Greenberg, Arvind Caprihan, Sudha Seshadri, Charles DeCarli, Claudia L. Satizábal   +20 more
openalex   +1 more source

Smart, Bio‐Inspired Polymers and Bio‐Based Molecules Modified by Zwitterionic Motifs to Design Next‐Generation Materials for Medical Applications

Advanced Functional Materials, EarlyView.
Bio‐based and (semi‐)synthetic zwitterion‐modified novel materials and fully synthetic next‐generation alternatives show the importance of material design for different biomedical applications. The zwitterionic character affects the physiochemical behavior of the material and deepens the understanding of chemical interaction mechanisms within the ...
Theresa M. Lutz, Jonas De Breuck, Sahar Salehi, Meike N. Leiske   +3 more
wiley   +1 more source

Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration

Lancet Neurology, 2013
J. Wardlaw, Eric E. Smith, G. Biessels, C. Cordonnier, F. Fazekas, R. Frayne, R. Lindley, J. O'Brien, F. Barkhof, O. Benavente, S. Black, C. Brayne, M. Breteler, H. Chabriat, C. DeCarli, F. de Leeuw, F. Doubal, Marco Duering, Nick C Fox, S. Greenberg, V. Hachinski, I. Kilimann, V. Mok, R. V. Oostenbrugge, L. Pantoni, O. Speck, B. Stephan, S. Teipel, A. Viswanathan, D. Werring, Christopher L H Chen, Colin Smith, M. van Buchem, B. Norrving, P. Gorelick, M. Dichgans   +35 more
semanticscholar   +1 more source

Expanding Chemical Space of Nucleic Acid Nanoparticles for Tunable Antiviral‐Like Immunomodulatory Responses and Potent Adjuvant Activity

Advanced Functional Materials, EarlyView.
We introduce a nucleic acid nanoparticle (NANP) platform designed to be rrecognized by the human innate immune system in a regulated manner. By changing chemical composition while maintaining constant architectural parameters, we identify key determinants of immunorecognition enabling the rational design of NANPs with tunable immune activation profiles
Martin Panigaj, Hannah S. Newton, Jian Wang, Laxmi Pandey, Yelixza I. Avilla, Phong Nguyen, Morgan Chandler, Justin Halman, Yasmine Radwan, Stephanie Smith, Elijah Edmondson, Simone Difilippantonio, Chelsea Sanders, Bao Tran, Yongmei Zhao, Shaojun Xie, Edward Cedrone, Barry W. Neun, Meni Wanunu, Nikolay V. Dokholyan, Marina A. Dobrovolskaia, Kirill A. Afonin   +21 more
wiley   +1 more source

A Vascular Microphysiological Model of Lung Fibrosis Reveals That Myofibroblasts and IPF Patient‐Derived Fibroblasts Impair Angiogenesis and Vasculogenesis

Advanced Functional Materials, EarlyView.
A microphysiological lung fibrosis model recapitulates myofibroblast–vascular interactions. Induced myofibroblasts and patient‐derived IPF fibroblasts impair angiogenesis and increase vascular permeability via TGF‐β1–driven signaling. Pharmacological interventions with SB 431542 and VEGF supplementation restore vascular morphology and barrier function.
Elena Cambria, Adriana Blazeski, Eunkyung Clare Ko, Tran Thai, Shania Dantes, David A. Barbie, Sarah E. Shelton, Roger D. Kamm   +7 more
wiley   +1 more source

Genetics of common cerebral small vessel disease

Nature Reviews Neurology, 2022
Constance Bordes, M. Sargurupremraj, A. Mishra, S. Debette   +3 more
semanticscholar   +1 more source

Pulmonary disease in small-vessel vasculitis

Cleveland Clinic Journal of Medicine, 2012
Diagnosis of the pulmonary manifestations of small-vessel vasculitis requires attention to detail, judicious use of imaging technology, and awareness of disorders that can mimic or masquerade as pulmonary vasculitis. Treatment should begin with pharmacologic intervention to manage the underlying inflammatory disorder.
openaire   +2 more sources

A Smart Bio‐Battery Facilitates Diabetic Bone Defect Repair Via Inducing Macrophage Reprogramming and Synergistically Modulating Bone Remodeling Coupling

Advanced Functional Materials, EarlyView.
This research presents a novel implantable bio‐battery, GF‐OsG, tailored for diabetic bone repair. GF‐OsG generates microcurrents in high‐glucose conditions to enhance vascularization, shift macrophages to the M2 phenotype, and regulate immune responses.
Nanning Lv, Haifu Sun, Wenxiang Tang, Yonggang Li, Zhonglai Qian, Lihui Hong, Chong Chen, Hongye Li, Jiaxiang Bai, Yusen Qiao, Mingming Liu   +10 more
wiley   +1 more source