Results 81 to 90 of about 1,601,455 (409)

Inhibitor of DNA binding‐1 is a key regulator of cancer cell vasculogenic mimicry

Molecular Oncology, EarlyView.
Elevated expression of transcriptional regulator inhibitor of DNA binding 1 (ID1) promoted cancer cell‐mediated vasculogenic mimicry (VM) through regulation of pro‐angiogenic and pro‐cancerous genes (e.g. VE‐cadherin (CDH5), TIE2, MMP9, DKK1). Higher ID1 expression also increased metastases to the lung and the liver.
Emma J. Thompson, Emma L. Dorward, Kristyn Jurrius, Nathalie Nataren, Markus Tondl, Kay K. Myo Min, Michaelia P. Cockshell, Anahita Fouladzadeh, John Toubia, Mark DeNichilo, Delphine Merino, Claudine S. Bonder   +11 more
wiley   +1 more source

Arterial Stiffness and Cerebral Small Vessel Disease

Frontiers in Neurology, 2018
Background and Objective: Studies on relations between arterial stiffness and full spectrum of radiological features of cerebral small vessel disease (CSVD) are scarce.
Fei-Fei Zhai, Yi-Cong Ye, Si-Yu Chen, Fa-Ming Ding, Fei Han, Xing-Lin Yang, Quan Wang, Li-Xin Zhou, Jun Ni, Ming Yao, Ming-Li Li, Zheng-Yu Jin, Li-Ying Cui, Shu-Yang Zhang, Yi-Cheng Zhu   +14 more
doaj   +1 more source

GAEI-UNet: Global Attention and Elastic Interaction U-Net for Vessel Image Segmentation [PDF]

arXiv, 2023
Vessel image segmentation plays a pivotal role in medical diagnostics, aiding in the early detection and treatment of vascular diseases. While segmentation based on deep learning has shown promising results, effectively segmenting small structures and maintaining connectivity between them remains challenging.
arxiv  

A comparison of location of acute symptomatic vs. 'silent' small vessel lesions [PDF]

, 2015
Background: Acute lacunar ischaemic stroke, white matter hyperintensities, and lacunes are all features of cerebral small vessel disease. It is unclear why some small vessel disease lesions present with acute stroke symptoms, whereas others typically do ...
Bailey EL, Bamford J, Chowdhury D, Clayden JD, De Maesschalck R, Del Bene A, Fisher CM, Fukui T, Haley AP, Jackson CA, Kimberly WT, Longstreth WT, Loos CM, Moreau F, O'Sullivan M, Oishi K, Potter GM, Rost NS, Sacco S, Saini M, Valdes Hernandez M, Valdes Hernandez MC, Viswanathan A, Wardlaw JM, Wardlaw JM, Wardlaw JM, Wardlaw JM, Wen W, Wright CB   +28 more
core   +2 more sources

Loss of proton‐sensing GPR4 reduces tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
G protein‐coupled receptor 4 (GPR4) is a pH‐sensing receptor activated by acidic pH. GPR4 expression is increased in patients with inflammatory bowel disease who are at high risk of developing colorectal cancer. In mouse models, loss of GPR4 attenuated tumor progression. This correlated with increased IL2 and natural killer cell activity.
Leonie Perren, Moana Busch, Pedro A. Ruiz, Ermanno Malagola, Valeria Baumeler, Federica Foti, Adelina Gross, Tobias Grütter, Hendrik Edel, Cordelia Schuler, Kristina Handler, Glenn De Lange, Isabelle C. Arnold, Cheryl de Vallière, Klaus Seuwen, Martin Hausmann, Gerhard Rogler   +16 more
wiley   +1 more source

Claw U-Net: A Unet-based Network with Deep Feature Concatenation for Scleral Blood Vessel Segmentation [PDF]

arXiv, 2020
Sturge-Weber syndrome (SWS) is a vascular malformation disease, and it may cause blindness if the patient's condition is severe. Clinical results show that SWS can be divided into two types based on the characteristics of scleral blood vessels. Therefore, how to accurately segment scleral blood vessels has become a significant problem in computer-aided
arxiv  

Cerebral small-vessel disease is associated with the severity of diabetic retinopathy in type 1 diabetes [PDF]

, 2021
Introduction Cerebral small-vessel disease is common in neurologically asymptomatic individuals with type 1 diabetes. The retinal vasculature is thought to mirror the brain's vasculature, but data on this association are limited in type 1 diabetes.
Eriksson, Marika, FinnDiane Study Grp, Forsblom, Carol, Gordin, Daniel, Groop, Per-Henrik, Liebkind, Ron, Martola, Juha, Putaala, Jukka, Shams, Sara, Summanen, Paula, Tatlisumak, Turgut, Thorn, Lena M.   +11 more
core   +1 more source

Cerebral small vessel disease and Alzheimer’s disease

Clinical Interventions in Aging, 2015
Cerebral small vessel disease (CSVD) is a group of pathological processes with multifarious etiology and pathogenesis that are involved into the small arteries, arterioles, venules, and capillaries of the brain. CSVD mainly contains lacunar infarct or lacunar stroke, leukoaraiosis, Binswanger's disease, and cerebral microbleeds.
Liang-Jun Yan, Zhengang Tang, Zhiyou Cai, Hanjun Tu, Wenbo He, Chuanling Wang, Ming Xiao   +6 more
openaire   +5 more sources

Loss of primary cilia promotes EphA2‐mediated endothelial‐to‐mesenchymal transition in the ovarian tumor microenvironment

Molecular Oncology, EarlyView.
Loss of primary cilia in endothelial cells promotes EndMT and vascular abnormalities in the ovarian tumor microenvironment through EphA2 activation. Using human samples, in vitro models, and endothelial‐specific Kif3a‐knockout mice, we show that primary cilia loss drives the acquisition of cancer‐associated fibroblast‐like phenotypes, thereby ...
Jin Gu Cho, Yubin Hah, Eunsik Yun, Hye In Ka, Aram Lee, Sora Han, Dawn Lee, Sung Wook Kim, Jong Hoon Park, Byung Su Kwon, Young Yang, Jongmin Kim   +11 more
wiley   +1 more source

Cerebral small vessel disease and cognitive impairment

Journal of Neurorestoratology, 2019
Cerebral small vessel disease (CSVD) is a pathophysiological process involving small arteries such as cerebellar arteries, arterioles, capillaries, and veinlets.
Lifang Meng, Jianhua Zhao, Junli Liu, Shaomin Li   +3 more
doaj   +1 more source