Results 81 to 90 of about 1,168,068 (349)
Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity
Molecular Oncology, EarlyView.A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh +8 morewiley +1 more sourceCognitive impairment and amygdala subregion volumes in elderly with cerebral small vessel disease: A large prospective cohort study
Neurobiology of DiseaseAlthough the amygdala is associated with cognitive impairment resulting from cerebral small vessel disease, the relationship between alterations in amygdala structure and cerebral small vessel disease (CSVD) remains controversial. Given that the amygdala Zhenyu Cheng, Linfeng Yang, Jing Li, Yiwen Chen, Pengcheng Liang, Yuanyuan Wang, Na Wang, Xinyue Zhang, Yian Gao, Chaofan Sui, Meng Li, Changhu Liang, Lingfei Guo +12 moredoaj +1 more sourceCerebral small vessel disease and Alzheimer's disease.
Clinical interventions in aging, 2015 Cerebral small vessel disease (CSVD) is a group of pathological processes with multifarious etiology and pathogenesis that are involved into the small arteries, arterioles, venules, and capillaries of the brain. CSVD mainly contains lacunar infarct or lacunar stroke, leukoaraiosis, Binswanger's disease, and cerebral microbleeds.Cai, Zhiyou, Wang, Chuanling, He, Wenbo, Tu, Hanjun, Tang, Zhengang, Xiao, Ming, Yan, Liang-Jun +6 moreopenaire +2 more sourcesMolecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines
Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed +12 morewiley +1 more sourceLINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico +12 morewiley +1 more sourceCerebral small vessel disease genomics and its implications across the lifespan
Nature Communications, 2020 White matter hyperintensities (WMH) are the most common brain-imaging feature of cerebral small vessel disease (SVD), hypertension being the main known risk factor.M. Sargurupremraj, Hideaki Suzuki, X. Jian, C. Sarnowski, T. Evans, J. Bis, G. Eiriksdottir, S. Sakaue, N. Terzikhan, Mohamad Habes, Wei Zhao, N. Armstrong, E. Hofer, L. Yanek, S. Hagenaars, Rajan B. Kumar, E. B. van den Akker, Rebekah E. McWhirter, S. Trompet, A. Mishra, Y. Saba, C. Satizabal, G. Beaudet, L. Petit, A. Tsuchida, L. Zago, Sabrina Schilling, S. Sigurdsson, R. Gottesman, C. Lewis, N. Aggarwal, O. Lopez, Jennifer A. Smith, M. V. Valdés Hernández, J. van der Grond, M. Wright, M. Knol, M. Dörr, R. Thomson, Constance Bordes, Quentin Le Grand, Marie-Gabrielle Duperron, A. Smith, D. Knopman, P. Schreiner, Denis A. Evans, J. Rotter, A. Beiser, S. M. Maniega, M. Beekman, J. Trollor, D. Stott, M. Vernooij, K. Wittfeld, W. Niessen, A. Soumaré, E. Boerwinkle, S. Sidney, S. Turner, G. Davies, A. Thalamuthu, U. Völker, M. van Buchem, R. Bryan, J. Dupuis, M. Bastin, D. Ames, A. Teumer, P. Amouyel, J. Kwok, R. Bülow, I. Deary, P. Schofield, H. Brodaty, Jiyang Jiang, Y. Tabara, K. Setoh, S. Miyamoto, Kazumichi Yoshida, M. Nagata, Y. Kamatani, F. Matsuda, B. Psaty, D. Bennett, P. D. De Jager, T. Mosley, P. Sachdev, R. Schmidt, H. Warren, E. Evangelou, David Trégouët, Philippe Mariza Saonli Claudine Jennifer A. Daniel I. Jean- Amouyel de Andrade Basu Berr Brody Chasman Dartigu, P. Amouyel, M. de Andrade, S. Basu, C. Berr, J. Brody, D. Chasman, J. Dartigues, A. Folsom, M. Germain, H. D. de Haan, J. Heit, J. Houwing-Duitermaat, C. Kabrhel, P. Kraft, Grégoire Legal, S. Lindström, R. Monajemi, P. Morange, B. Psaty, P. Reitsma, P. Ridker, L. Rose, F. Rosendaal, N. Saut, Eline P. Slagboom, D. Smadja, N. Smith, P. Suchon, Weihong Tang, K. Taylor, David Trégouët, C. Tzourio, M. D. de Visser, A. van Hylckama Vlieg, L. Weng, K. Wiggins, Padhraig Verneri Bendik S. Priit Tonu Tune H. Kai-How Ester Gormley Anttila Winsvold Palta Esko Pers Farh Cuen, P. Gormley, V. Anttila, B. Winsvold, P. Palta, T. Esko, T. Pers, Kai-How Farh, E. Cuenca-León, M. Muona, N. Furlotte, T. Kurth, A. Ingason, George Mcmahon, L. Ligthart, G. Terwindt, M. Kallela, T. Freilinger, C. Ran, S. Gordon, Anine H. Stam, S. Steinberg, G. Borck, M. Koiranen, L. Quaye, H. Adams, T. Lehtimäki, Antti-Pekka Sarin, J. Wedenoja, D. Hinds, J. Buring, M. Schürks, P. Ridker, Maria Gudlaug Hrafnsdottir, H. Stefánsson, S. Ring, J. Hottenga, B. Penninx, M. Färkkilä, V. Artto, M. Kaunisto, Salli Vepsäläinen, R. Malik, A. Heath, P. Madden, N. G. Martin, G. Montgomery, M. Kurki, M. Kals, R. Mägi, K. Pärn, E. Hämäläinen, Hailiang Huang, Andrea Byrnes, L. Franke, Jie Huang, E. Stergiakouli, Phil H. Lee, C. Sandor, C. Webber, Zameel M. Cader, Bertram Muller-Myhsok, Stefan Schreiber, T. Meitinger, J. Eriksson, V. Salomaa, K. Heikkilä, E. Loehrer, A. Uitterlinden, A. Hofman, Cornelia M. Van Duijn, L. Cherkas, L. Pedersen, A. Stubhaug, C. Nielsen, M. Männikkö, E. Mihailov, L. Milani, H. Göbel, A. Esserlind, Anne Francke Christensen, Thomas Folkmann Hansen, T. Werge, J. Kaprio, A. Aromaa, O. Raitakari, M. A. Ikram, T. Spector, M. Järvelin, A. Metspalu, C. Kubisch, D. Strachan, M. Ferrari, A. C. Belin, M. Dichgans, M. Wessman, A. M. van den Maagdenberg, J. Zwart, D. Boomsma, G. Davey Smith, K. Stefánsson, N. Eriksson, M. Daly, B. Neale, Jes Olesen, D. Chasman, D. Nyholt, A. Palotie, M. A. Ikram, W. Wen, C. DeCarli, V. Srikanth, J. Jukema, Eline P. Slagboom, S. Kardia, Y. Okada, B. Mazoyer, J. Wardlaw, P. Nyquist, K. Mather, H. Grabe, H. Schmidt, Cornelia M. Van Duijn, V. Gudnason, W. Longstreth, L. Launer, M. Lathrop, S. Seshadri, C. Tzourio, H. Adams, P. Matthews, M. Fornage, S. Debette +260 moresemanticscholar +1 more sourceThrombolytic proteins profiling: High‐throughput activity, selectivity, and resistance assays
FEBS Open Bio, EarlyView.We present optimized biochemical protocols for evaluating thrombolytic proteins, enabling rapid and robust screening of enzymatic activity, inhibition resistance, and fibrin affinity, stimulation, and selectivity. The outcome translates to key clinical indicators such as biological half‐life and bleeding risk. These assays streamline the development of Martin Toul, Alan Strunga, Jiri Damborsky, Zbynek Prokop +3 morewiley +1 more source
