Results 81 to 90 of about 1,093,638 (350)

Gut alterations in a chronic kidney disease rat model with diet‐induced vascular calcification

FEBS Open Bio, EarlyView.
Chronic kidney disease (CKD) patients often suffer from intestinal and/or mineral and bone disorders. Using a rat model, we showed that uremic vascular calcification is associated with gut barrier alterations (decreased gut mucus production and Nlrp6 gene expression, increased gut inflammation), and plasma retention of gut‐origin uremic toxins (indoxyl
Piotr Bartochowski, Irene Cortijo, Shruti Bhargava, Bernard Jover, Fabrice Raynaud, Juliana H Boukhaled, Anne‐Dominique Lajoix, Vera Jankowski, Joachim Jankowski, Magali Cordaillat‐Simmons, Àngel Argilés, Nathalie Gayrard, Flore Duranton, Jonas Laget   +13 more
wiley   +1 more source

Cognitive impairment in cerebral small vessel disease induced by hypertension

Neural Regeneration Research
Hypertension is a primary risk factor for the progression of cognitive impairment caused by cerebral small vessel disease, the most common cerebrovascular disease.
Weipeng Wei, Denglei Ma, Lin Li, Lan Zhang   +3 more
doaj   +1 more source

Prevention and Management of Cerebral Small Vessel Disease [PDF]

Journal of Stroke, 2015
Lacunar infarcts/lacunes, white matter hyperintensities (WMH), and cerebral microbleeds (CMBs) are considered various manifestations of cerebral small vessel disease (SVD).
Vincent Mok, Jong S. Kim
doaj   +1 more source

Watching Small Vessel Disease Grow [PDF]

Circulation Research, 2018
Cerebrovascular disease is a major contributor to loss of brain health, a leading medical, societal, and financial issue worldwide.1 Although ischemic and hemorrhagic strokes are widely known end-organ effects, diseases of the cerebral circulation are important contributors to mild cognitive deficits, dementia, and an array of neurological and ...
openaire   +3 more sources

Iron‐dependent lysosomal LDL oxidation induces the expression of scavenger receptor A in human THP‐1 monocytes

FEBS Open Bio, EarlyView.
In human monocytic cells THP‐1, a limited uptake of native—not oxidized—LDL/VLDL induced expression of scavenger receptor A and cellular adhesion. Induction was inhibited by lysosomotropic (WR‐1065) and lipophilic (BHT) antioxidants and by siRNAs against ferritinophagy.
Martina Čierna, Richard Buchal, Martin Leníček, Amit Shachak, Jan Pláteník   +4 more
wiley   +1 more source

The impact of frailty syndrome on skeletal muscle histology: preventive effects of exercise

FEBS Open Bio, EarlyView.
Frailty syndrome exacerbates skeletal muscle degeneration via increased ECM deposition and myofiber loss. This study, using a murine model, demonstrates that endurance exercise attenuates these histopathological alterations, preserving muscle integrity. Findings support exercise as a viable strategy to counteract frailty‐induced musculoskeletal decline
Fujue Ji, Hae Sung Lee, Haesung Lee, Jong‐Hee Kim   +3 more
wiley   +1 more source

Simple MRI score aids prediction of dementia in cerebral small vessel disease

Neurology, 2020
Objective To determine whether a simple small vessel disease (SVD) score, which uses information available on rapid visual assessment of clinical MRI scans, predicts risk of cognitive decline and dementia, above that provided by simple clinical measures.
Ali Amin Al Olama, J. Wason, A. Tuladhar, Esther M C van Leijsen, M. Koini, E. Hofer, R. Morris, R. Schmidt, F. de Leeuw, H. Markus   +9 more
semanticscholar   +1 more source

Advanced Neuroimaging of Cerebral Small Vessel Disease [PDF]

Current Treatment Options in Cardiovascular Medicine, 2017
Cerebral small vessel disease (SVD) is characterised by damage to deep grey and white matter structures of the brain and is responsible for a diverse range of clinical problems that include stroke and dementia. In this review, we describe advances in neuroimaging published since January 2015, mainly with magnetic resonance imaging (MRI), that, in ...
Blair, Gordon W., Hernandez, Maria Valdez, Thrippleton, Michael J., Doubal, Fergus N., Wardlaw, Joanna M.   +4 more
openaire   +4 more sources

The role of circular RNAs in regulating cytokine signaling in cancer

FEBS Open Bio, EarlyView.
Cytokines present in the tumor microenvironment fuel cancer development. Aberrant expression of circRNAs contributes to cancer progression. Cytokines are involved in regulating circRNA biogenesis. Furthermore, aberrantly expressed circRNAs regulate the expression of ligands, receptors, and downstream effectors involved in cytokine signaling to promote ...
Vandana Joshi, Swati, Amit Mishra, Amaresh Panda, Vivek Sharma   +4 more
wiley   +1 more source

Contributions of Aging to Cerebral Small Vessel Disease.

Annual Review of Physiology, 2020
Cerebral small vessel disease (SVD) is characterized by changes in the pial and parenchymal microcirculations. SVD produces reductions in cerebral blood flow and impaired blood-brain barrier function, which are leading contributors to age-related ...
T. D. De Silva, F. Faraci
semanticscholar   +1 more source