Results 111 to 120 of about 6,718,160 (287)

Precision Nanomedicine for Traumatic Neural Injury: Functional Paradigms and Translational Frameworks

Advanced Science, EarlyView.
This review presents a pathology‐driven framework unifying nanomedicine across TBI, SCI, and PNI. Epidemiological evidence and comparative single‐cell transcriptomic reanalysis define shared pathological modules, injury‐specific effectors, and therapeutic bottlenecks. Six functional paradigms connect nanomaterial structure and biological fate to injury‐
Mouyuan Sun, Shuangyang Li, Zhixu He, Jingyi Xie, Yaxian Luo, Xuankai Fan, Jingyu Zhang, Luying Qin, Lianjie Peng, Tao Qiu, Tian Zhang, Huiming Wang, Mengfei Yu   +12 more
wiley   +1 more source

Free radical scavenger, edaravone, reduces the lesion size of lacunar infarction in human brain ischemic stroke

BMC Neurology, 2011
Background Although free radicals have been reported to play a role in the expansion of ischemic brain lesions, the effect of free radical scavengers is still under debate.
Suzuki Akifumi, Yoshioka Shotaroh, Nakase Taizen   +2 more
doaj   +1 more source

Collateral Circulation and Outcome in Atherosclerotic Versus Cardioembolic Cerebral Large Vessel Occlusion

, 2019
Background and Purpose-Due to chronic hypoperfusion, cervical atherosclerosis may promote cerebral collateral circulation. We hypothesized that patients with ischemic stroke due to cervical carotid atherosclerosis have a more extensive collateral ...
Roos, Yvo B. W. E. M., Goldhoorn, Robert-Jan B., de Kort, Paul L. M., Dallinga, Rene J., Guglielmi, Valeria, van Hasselt, Boudewijn A. A. M., Wermer, Marieke J. H., van Oostenbrugge, Robert J., Zinkstok, Sanne M., Emmer, Bart J., Tolhuisen, Manon, Nijeholt, Geert J. Lycklama A., Aerden, Leo A. M., van Dijk, Ewoud J., Roozenbeek, Bob, Martens, Jasper M., van der Lugt, Aad, Roosendaal, Stefan D., Compagne, Kars C. J., Alves, Heitor, Eker, Reyhan, Postma, Alida A.; id_orcid, Keizer, Koos, Vos, Jan A., Schreuder, Tobien H. C. M. L., van Zwam, Wim H., Heijboer, Roel J. J., LeCouffe, Natalie E., Treurniet, Kilian M., Hofmeijer, Jeannette, Boers, Anna M. M., Majoie, Charles B. L. M., Postma, Alida A., van der Worp, H. Bart, Dippel, Diederik W. J., Berkhemer, Olvert A., Coutinho, Jonathan M., Marquering, Henk A., Staals, Julie, Groot, P. F. C., Boiten, Jelis, Uyttenboogaart, Maarten, van den Berg, René, van den Berg, Jan S. P., Schonewille, Wouter J., Lycklama À Nijeholt, Geert J., van Dijk, Lukas C., Boogaarts, Hieronymus D., van Kranendonk, Katinka R., Peluso, Jo P., Jansen, Ivo G. H., Sprengers, Marieke E. S., van Walderveen, Marianne A. A., Lo, Rob H., de Bruijn, Sebastiaan F., Hinsenveld, Wouter, Eshghi, Omid, Tolhuisen, Manon L., Kappelhof, Manon, Mulder, Maxim J. H. L., Beenen, Ludo F. M.   +60 more
core   +1 more source

AKAP1 Protects Retinal Ganglion Cells and Preserves Vision by Improving Mitochondrial and Synaptic Health in Glaucomatous Neurodegeneration

Advanced Science, EarlyView.
Intravitreal AAV2‐mediated AKAP1 restoration enhances mitochondrial fusion and biogenesis, improves bioenergetic capacity, and preserves mitochondrial integrity in glaucomatous RGCs. AKAP1 stabilizes presynaptic structure, maintaining synaptic protein expression, and limiting complement‐associated neuroinflammation.
Tonking Bastola, Keun‐Young Kim, Ziyao Shen, Guy A. Perkins, Muna Poudel, Yoonjin Lim, Hyejeong Choi, Soo‐Ho Choi, Mark H. Ellisman, Robert N. Weinreb, Won‐Kyu Ju   +10 more
wiley   +1 more source

Multiple small-vessel occlusions in systemic lupus erythematosus. [PDF]

Stroke, 1989
R A Asherson, E Baguley, M A Khamashta, G R Hughes   +3 more
openaire   +1 more source

Community Stroke Practice Experience with Small Vessel Thrombectomy

, 2019
Emergent endovascular revascularization is currently mainstay for patients presenting with emergent Large Vessel Occlusion (LVO) of the intracranial circulation Stroke symptoms affecting smaller vessels can carry significant morbidity Newer technologies ...
Carr, Kevin, MD, Pasquale, David, MD, Serulle, Yafell, MD, Thwing, Zachary, MD, Shivashankar, Ravishankar, MD   +4 more
core  

Branch vessel occlusion in aneurysm treatment with flow diverter stent

, 2020
: Flow diverter placement for treatment of intracranial aneurysms gained growing consensus in the past years. A major concern among professionals is the side branch coverage which leads in some cases to vessel occlusion.
Paolucci, Aldo, Carrafiello, Gianpaolo, Caranci, Ferdinando, Conte, Giorgio, Angileri, Alessio, Levi, Daniel, Hohenstatt, Sophia, Craparo, Giuseppe, Arrichiello, Antonio   +8 more
core   +1 more source

Astrocytic Ketogenesis Protects Central Nervous System Injury via CPT1A Stabilization and Epigenetic Regulation

Advanced Science, EarlyView.
A distinct astrocyte subpopulation, enriched at the lesion border, drives CNS repair through enhanced ketone body metabolism. This process promotes neuronal survival and axonal sparing via CPT1A stabilization and H3K9bhb‐dependent epigenetic reprogramming, positioning astrocytic ketogenesis as a promising therapeutic target for tissue regeneration ...
Dishui Pan, Haoming Shu, Rui Gao, Yilong Ren, Wu Ye, Xuhui Ge, Yao Gu, Yufeng Zhu, Xiaokun Wang, Honglin Teng, Xuhui Zhou, Wei Liu, Yang Gao, Jianquan Zhao, Weihua Cai   +14 more
wiley   +1 more source

Cardiac Endothelial Enhancer RNA Tek‐e1 Restores Microvascular Homeostasis After Myocardial Infarction

Advanced Science, EarlyView.
Hypoxia‐induced KDM5A downregulation establishes a distinct endothelial repair programme, increasing H3K4me3 at the Tek promoter and intronic enhancer, enabling ISL1 to coordinately activate Tek transcription and induce enhancer‐RNA Tek‐e1. This cis‐regulatory RNA is essential for additional Tek/TIE2 induction through R‐loop formation and reinforced ...
Yang Lyu, Kun Yang, Yunzhi Ling, Jiahui Cheng, Jiaran Shi, Shiyu Hu, Changyi Zhou, Wei Wei, Hanchuan Chen, Xiang Wei, Zengru Wang, Zhi Xiong, Chenxi Yang, Su Zou, Rui Shen, Yuanyue Song, Gaofeng Zhang, Rifeng Gao, Kaiyang Lin, Yingjia Xu   +19 more
wiley   +1 more source

Budd–Chiari Syndrome with Patent Hepatic Veins on Imaging: Clinicoradiological Spectrum of Small Vessel Occlusion and Partial Thrombosis of Large Veins

Journal of Clinical Interventional Radiology ISVIR
Budd–Chiari Syndrome (BCS) usually involves thrombosis or obstruction of major hepatic veins. However, a subset of patients can present with atypical features where hepatic veins appear patent on imaging.
Rajesh Sasidharan, Shubham Suryavanshi, Akhil Baby, Sunitha Thomas, Cyriac Abby Philips   +4 more
doaj   +1 more source