Tadalafil may improve cerebral perfusion in small-vessel occlusion stroke-a pilot study. [PDF]
Brain Commun, 2020 Abstract New treatments for cerebral small-vessel disease are needed to reduce the risk of small-vessel occlusion stroke and vascular cognitive impairment. We investigated an approach targeted to the signalling molecule cyclic guanosine monophosphate, using the phosphodiesterase 5 inhibitor tadalafil, to explore if it improves ...
Ölmestig J +7 more
europepmc +7 more sources
Mechanical thrombectomy for large vessel occlusion with large ischaemic core
Advances in Clinical Neuroscience & RehabilitationEndovascular therapy in acute ischemic stroke with large vessel occlusion changed the landscape of stroke treatment. Early randomised trials largely focused on patients with small to moderate ischemic core defined as ASPECTS 6 or greater.
Thanh N. Nguyen +5 more
doaj +2 more sources
Intravenous thrombolysis with tissue-plasminogen activator in small vessel occlusion
Journal of Clinical Neuroscience, 2019 Intravenous tissue-plasminogen activator (IV-TPA) treatment in acute ischemic stroke (AIS) patients due to small vessel occlusion (SVO) has been debated because of its small expected benefit and symptomatic intracranial hemorrhage (SICH) risk. Furthermore, data on subgroups of SVO patients are limited.
Young Min, Paek +19 more
openaire +3 more sources
The functional impact on donor vessel following transcatheter closure of coronary artery fistulas—a retrospective study using QFR analysis [PDF]
Frontiers in Cardiovascular MedicineBackgroundThe impact of transcatheter closure of coronary artery fistula (CAF) and residual shunt after occlusion on improving blood flow in the donor vessel remains uncertain.ObjectivesTo evaluate the functional impact on the donor vessel following CAFs
Zhenchi Sang +5 more
doaj +2 more sources
Immediate Small Side Branch Occlusion after Percutaneous Coronary Intervention [PDF]
Journal of Tehran University Heart Center, 2007 Background: Small side branches, albeit less important than their larger counterparts, have not yet received due attention in the literature. Nor has there ever been a comparison between drug-eluting stents and bare metal stents apropos side branch ...
Mohammad Ali Ostovan, Reza Mollazadeh
doaj +3 more sources
Association of CYP26C1 Promoter Hypomethylation with Small Vessel Occlusion in Korean Subjects. [PDF]
Genes (Basel), 2021 The risk factors for stroke, a fatal disease, include type two diabetes, hypertension, and genetic influences. Small vessel occlusion (SVO) can be affected by epigenetic alterations, but an association between SVO and the methylation of cytochrome P450 family 26 subfamily C member 1 (CYP26C1) has not been identified.
Lee EJ, Kim MS, Yim NH, Cha MH.
europepmc +4 more sources
Deep medullary vein damage correlates with small vessel disease in small vessel occlusion acute ischemic stroke. [PDF]
Eur RadiolAbstract Objectives We aim to investigate whether cerebral small vessel disease (cSVD) imaging markers correlate with deep medullary vein (DMV) damage in small vessel occlusion acute ischemic stroke (SVO-AIS) patients. Methods The DMV was divided into six segments according ...
Wang X +21 more
europepmc +3 more sources
Serum Homocysteine Is Associated With HDL Only in Stroke Patients With Small Vessel Occlusion. [PDF]
Front Neurol, 2020 Background: Although controversial, homocysteine (Hcy) and lipid parameters have been associated with particular stroke subtypes. However, there are limited studies concerning the relationship between Hcy and lipid levels in acute ischemic stroke (AIS). We evaluated the impact of Hcy levels on lipid profiles in terms of specific stroke subtypes.Methods:
Kim Y +10 more
europepmc +5 more sources
Review: Preclinical Models of Large‐Vessel Occlusion Stroke
Stroke: Vascular and Interventional NeurologyPreclinical models of large‐vessel occlusion (LVO) stroke play an important role in testing novel thrombolytic and neuroprotective agents, as well as assessing endovascular devices for endovascular thrombectomy.
Alexander Keister +7 more
doaj +2 more sources
RGS5 rs4657251 polymorphism is associated with small vessel occlusion stroke in Taiwan Han Chinese. [PDF]
J Chin Med Assoc, 2020 Background: The regulator of G-protein signaling protein 5 (RGS5) has been demonstrated to play a role in regulating blood pressure and cardiovascular function. Studies have shown that RGS5 polymorphisms exhibit susceptibility to hypertension. However, no study has yet been performed among stroke patients.
Hsu LC, Hsu LS, Lee TH.
europepmc +4 more sources