Results 41 to 50 of about 2,700,191 (303)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

You’re an Engineer? You Must Be Really Smart! A Theoretical Discussion of the Need to Integrate “Smart” into Engineering Identity Research

Studies in Engineering Education, 2023
Background: Those who participate in engineering are often assumed to be smart by others. At the same time, the cultural construction of what counts as “smart” is biased and therefore functions as a barrier to broadening participation in engineering ...
Bailey Braaten, Emily Dringenberg, Amy Kramer, Rachel Kajfez   +3 more
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Combining Climate Smart Agriculture Practises Pays Off: Evidence on Food Security From Southern Highland Zone of Tanzania

Frontiers in Sustainable Food Systems, 2022
Concerns of food insecurity and climate change are serious global challenges, Tanzania included. In response, farm households are using various climate-smart agricultural practises (CSA-practises) which are believed to play a vital role to increase ...
Abiud J. Bongole, Joseph P. Hella, Kenneth M. K. Bengesi   +2 more
doaj   +1 more source

“It’s made a huge difference” : recognition, rights and the personal significance of Civil Partnership [PDF]

, 2007
In this paper we map briefly some of the arguments around the meaning and significance of the introduction of Civil Partnership in England and Wales, and in this way show how contested these meanings are.
Shipman, B., Smart, C.C.
core  

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Antibacterial hydrogel: The sniper of chronic wounds

BMEMat
Chronic wounds are wounds that are difficult to heal or do not follow the normal healing process. These include pressure ulcers, diabetic ulcers, venous ulcers, and arterial incomplete ulcers.
Shengtai Bian, Huijun Ye, Pan Wang, Changxing Li, Xutao Guo, Ming Guan, Shilun Feng   +6 more
doaj   +1 more source

SMART-1 Impact Ground-based campaign [PDF]

, 2007
Based on predictions of impact magnitude and cloud ejecta dynamics, we organized a SMART-1 ground-based observation campaign to perform coordinated measurements of the impact.
Albert, L., Alkalai, L., Ansari, S., Baldwin, E., Ball, A., Banerdt, B., Barbieri, C., Berezhnoy, A., Betts, B., Bhandari, N., Biver, N., Buckley, D., Buoso, M., Burchell, M., Burke, J. D., Chandrasekhar, T., Cirou, A., Colaprete, T., Cole, M., Cook, A. C., Cooke, B., Cremonese, G., Dantowitz, R., David, L., de Morais, V. M., Di Martino, M., Dighay, J.-L., Ehrenfreund, P., Erd, C., Ferri, F., Foing, B. H., Friedman, L., Goldstein, D., Gondoin, P., Graham, F., Gurvits, L., Hanslmeyer, A., Kasuga, T., Kato, M., Kawano, N., Khodachenko, M., Koschny, D., Koschny, D., Koschny, D., Krots, A., Lammer, H., Landeau-Constantin, J., Lawton, C., Lebreton, J. P., Levasseur-Regourd, A.-C., Lucey, P., Maley, P. D., Mangano, V., Marchis, F., Matsumoto, K., Meech, K., Montanes, P., Munoz, J. M. H., Ortiz, J. L., Palle, E., Reddy, V., Rossi, A., Rucker, H., Sanguy, O., Schultz, P. H., Schultz, R., Sugita, S., Svedhem, H., Talevi, M., Taylor, C., Taylor, C., Taylor, E., Tokunaga, A., Trigo-Rodriguez, J., Vaubaillon, J., Veillet, C., Vennes, S., Weyhe, B. v., Williams, S., Wood, M., Wooden, D.   +80 more
core  

Testing of Smart TV Applications: Key Ingredients, Challenges and Proposed Solutions

, 2019
Smart TV applications are software applications that have been designed to run on smart TVs which are televisions with integrated Internet features. Nowadays, the smart TVs are going to dominate the television market, and the number of connected TVs is ...
Ahmed, Bestoun S., Bures, Miroslav
core   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source