Results 31 to 40 of about 2,257 (224)

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

From Cosmetics to Innovative Cosmeceuticals—Non-Woven Tissues as New Biodegradable Carriers

Cosmetics, 2021
Due to pollution and climate-change fear, further increased by the COVID19 pandemic, consumers are looking for body and mind health by the request of more effective and safe products, including the anti-aging skincare cosmeceuticals..
Pierfrancesco Morganti, Gianluca Morganti, Alessandro Gagliardini, Alka Lohani   +3 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Smart city and sustainability indicators: a bibliometric literature review

Discover Sustainability
This study delves into the pivotal role that indicators play in designing, assessing, and guiding policies for sustainable urban development. Indicators, encompassing both quantitative and qualitative measures, serve as essential tools in evaluating ...
Leonardo da Silva Tomadon, Edivando Vitor do Couto, Walter Timo de Vries, Yara Moretto   +3 more
doaj   +1 more source

Real-Time Load Forecasting and Adaptive Control in Smart Grids Using a Hybrid Neuro-Fuzzy Approach

Energies
The transition to smart grids is revolutionizing the management and distribution of electrical energy. Nowadays, power systems must precisely estimate real-time loads and use adaptive regulation to operate in the era of sustainable energy.
Fangzong Wang, Zuhaib Nishter
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Engaging Young People in the Development of Innovative Nature-Inspired Technologies for Carbon Sequestration in Cities: Case Studies from Portugal

Smart Cities
Currently, cities are the most vulnerable places on the planet to the effects of global change, both anthropogenic and climate-related, and this is not compatible with harmony and well-being regarding the economy, nature, and future generations.
Manuela Moreira da Silva, Lurdes Ferreira, Teresa Sarmento, Catarina Selada   +3 more
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

STANDARDIZATION AND UNIFICATION OF METADATA TO ENSURE THE DEVELOPMENT OF “SMART” SUSTAINABLE CITIES

Соціальна економіка, 2018
The article focuses on the study of the essence, the principles of compilation and the scope of international standards ISO (International Organization for Standardization) application, which summarize the best practices in a wide range of areas that ...
Oleksiy S. Korepanov, Tatyana G. Chala, Iuliia O. Lazebnyk   +2 more
doaj