Results 51 to 60 of about 93,373 (292)
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Durability and Smart Condition Assessment of Ultra-High Performance Concrete in Cold Climates [PDF]
, 2016 The goals of this study were to develop ecological ultra-high performance concrete (UHPC) with local materials and supplementary cementitious materials and to evaluate the long-term performance of UHPC in cold climates using effective mechanical test ...
Allena, Srinivas +2 more
core
Privacy-Friendly Mobility Analytics using Aggregate Location Data [PDF]
, 2016 Location data can be extremely useful to study commuting patterns and disruptions, as well as to predict real-time traffic volumes. At the same time, however, the fine-grained collection of user locations raises serious privacy concerns, as this can ...
De Cristofaro, Emiliano +2 more
core +2 more sources
Smart-aggregation imaging for single molecule localisation with SPAD cameras [PDF]
Scientific Reports, 2016 AbstractSingle molecule localisation microscopy (SMLM) has become an essential part of the super-resolution toolbox for probing cellular structure and function. The rapid evolution of these techniques has outstripped detector development and faster, more sensitive cameras are required to further improve localisation certainty.
Gyongy, Istvan +6 more
openaire +4 more sources
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
Advances in the development of piezoelectric smart aggregates for structural health monitoring
Journal of Intelligent ConstructionIn recent times, due to the rapid infrastructure development worldwide, the use of concrete has greatly increased. However, concrete structures face various risks such as dynamic forces from winds or earthquakes and environmental impacts such as ...
Jianpeng Jin +4 more
doaj +1 more source
Microcracking in piezoelectric materials by the Boundary Element Method [PDF]
, 2019 A 3D boundary element model for piezoelectric polycrystalline micro-cracking is discussed in this contribution. The model is based on the boundary integral representation of the electro-mechanical behavior of individual grains and on the use of a ...
Benedetti, I., Gulizzi, V., Milazzo, A.
core
Comparison of intelligent charging algorithms for electric vehicles to reduce peak load and demand variability in a distribution grid [PDF]
, 2012 A potential breakthrough of the electrification of the vehicle fleet will incur a steep rise in the load on the electrical power grid. To avoid huge grid investments, coordinated charging of those vehicles is a must.
D'hulst, Reinhilde +2 more
core +1 more source
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Water presence detection in a concrete crack using smart aggregates
International Journal of Smart and Nano Materials, 2015 Liquid migrating into existing concrete cracks is a serious problem for the reliability of concrete structures and can sometimes induce full concrete structural failures.
Qingzhao Kong, Qian Feng, Gangbing Song
doaj +1 more source