Results 31 to 40 of about 125,149 (262)
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Energies, 2021 Vehicle driveability is one of the important attributes in range-extender electric vehicles due to the electric motor torque characteristics at low-speed events.
Raja Mazuir Raja Ahsan Shah +5 more
doaj +1 more source
Sustainable bioplastics manufacturing from renewable sources
FEBS Open Bio, EarlyView.Bioplastics are manufactured by using polymers from different bio‐based sources. These novel materials not only offer biodegradability but also possess various functional properties that make them suitable for diverse applications. Recent developments in the preparation of bioplastics are reported, highlighting the distinct properties of each type of ...
C. Valeria L. Giosafatto +6 more
wiley +1 more source
Integrating of principles of smart growth and infill development strategy for identifying physical capacities for inner development of city (Case study: Region 3 of Tabriz) [PDF]
جغرافیا و توسعه, 2019 Most of the cities in the world are facing with numerous problems due to their fast growing. While it is well-known that increased population is the primary reason for increasing the cities in size, the unreasonable dispersion affects the natural and ...
hasan mahmoudzadeh, Roya Abedini eranoog
doaj +1 more source
Enzymatic degradation of biopolymers in amorphous and molten states: mechanisms and applications
FEBS Open Bio, EarlyView.This review explains how polymer morphology and thermal state shape enzymatic degradation pathways, comparing amorphous and molten biopolymer structures. By integrating structure–reactivity principles with insights from thermodynamics and enzyme engineering, it highlights mechanisms that enable efficient polymer breakdown.
Anđela Pustak, Aleksandra Maršavelski
wiley +1 more source
Policy Debate: How EPA research, policies, and programs can advance urban sustainability
Sustainability: Science, Practice, & Policy, 2007 How can a regulatory agency with historic roots in controlling pollution implement sustainability? How does an agency organized by individual media offices for air, water, toxics, and waste develop an integrated systems approach to environmental ...
Alan D. Hecht, William H. Sanders III
doaj
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background Myasthenia gravis (MG) is a rare disorder characterized by fluctuating muscle weakness with potential life‐threatening crises. Timely interventions may be delayed by limited access to care and fragmented documentation. Our objective was to develop predictive algorithms for MG deterioration using multimodal telemedicine data ...
Maike Stein +7 more
wiley +1 more source
International Journal of Urban Sustainable Development, 2023 This study proposes an exploratory urban morphology agent-based model (ABM) to simulate the combined impact of the establishment of hub facilities that urban residents can conveniently access, policies for promoting human interactions around them, and ...
Hideyuki Nagai, Setsuya Kurahashi
doaj +1 more source