Results 131 to 140 of about 3,380,330 (332)

Background and approach to a definition of smart buildings [PDF]

open access: yes, 2014
There is no possibility of finding a single reference about domotics in the first half of the 20th century. The best known authors and those who have documented this discipline, set its origin in the 1970’s, when the x-10 technology began to be used, but
Ganah, Abdulkadir   +4 more
core  

GATA4‐Driven Transcription of HtrA1 Promotes Cellular Senescence in Ménière's Disease and Age‐Related Audio‐Vestibular Dysfunction

open access: yesAdvanced Science, EarlyView.
This study identifies the HDAC6/GATA4/HtrA1 axis as a critical driver of cellular senescence in the inner ear. GATA4 nuclear translocation, facilitated by HDAC6 downregulation, transcriptionally activates HtrA1, promoting hair cell senescence, SASP, and audio‐vestibular dysfunction in models of Ménière's disease and age‐related audio‐vestibular ...
Na Zhang   +16 more
wiley   +1 more source

Smartness. The face of the integration in the new “performing” society [PDF]

open access: yes, 2018
Economia, potere, così come case, persone e lavoro, ma prima di ogni altra cosa città: tutto negli ultimi anni è chiamato a diventare “smart”. È questa l’era della smart economy, della smart governance, della smart home, delle smart people, dello smart
Iannone, Roberta
core  

Fibrates Inhibit PLTP‐induced M2 Macrophage Infiltration and Increase the Sensitivity of Hepatocellular Carcinoma to ICIs

open access: yesAdvanced Science, EarlyView.
Phospholipid transfer protein(PLTP) plays a critical role in forming a complex with kinase A (AURKA) and P65. This interaction facilitates phosphorylation of P65 at Ser536, leading to the activation of the NF‐κB signaling pathway. Ultimately, this leads to the upregulation of downstream cytokines, including IL‐6, IL‐8, and CSF‐1, which promotes M2 ...
Xinyue Liang   +14 more
wiley   +1 more source

Paternal Circadian Disruption Impairs Offspring Cognition via Sperm microRNAs

open access: yesAdvanced Science, EarlyView.
Paternal circadian disruption remodels the sperm small RNA payload, elevating miR‐92a‐3p/miR‐25‐3p levels and perturbing early embryonic gene regulatory programs. Microinjection experiments and single‐embryo transcriptomics reveal sex‐specific developmental vulnerabilities, ultimately impairing offspring hippocampal synaptic plasticity and cognition ...
Kexin Zou   +22 more
wiley   +1 more source

Flexible management of smart homes

open access: yesJournal of Ambient Intelligence and Smart Environments, 2011
An approach is presented for flexible management of smart homes, covering both home automation and telecare. The aim is to allow end users to manage their homes without requiring detailed technical knowledge or programming ability. This is achieved at three levels: managing home components and their interactions, stating policies for how the home ...
openaire   +2 more sources

Smart Home

open access: yes, 2016
Abstract:   Objective- Smart Home is an efficient implementation of Internet of Things (IoT) for controlling and monitoring home appliances without much human intervention. This project aims at designing a climbable and price effective home automation system that controls home appliances via smart phone.
Aneena Joy   +4 more
openaire   +2 more sources

Dissertation: Examining and investigating home modifications and smart home technologies to reduce fall injury among older adults. [PDF]

open access: yes, 2019
Nearly one in six U.S. residents are over the age of 65. The proportion of older adults in the U.S. is anticipated to grow to 22.1% of the total population by 2050.
Kwan, Kevin Parker
core  

Organ‐Specific and Conserved Regulatory Logic Orchestrates Gene Expression in the Embryonic Mesothelium

open access: yesAdvanced Science, EarlyView.
Integrated multi‐omic profiling maps the gene‐regulatory landscape of the coelomic mesothelium across heart, lung, and pancreas. A cardiac‐restricted regulatory program is uncovered in which TBX20 activates heart mesothelial (epicardial) cis‐regulatory elements, while MAF emerges as a conserved regulator of mesothelial identity.
Quang Minh Dang   +3 more
wiley   +1 more source

Humanized and Charge‐Optimized CSPG4‐Specific CAR‐T Cells show Enhanced Efficacy against Head and Neck Squamous Cell Carcinoma

open access: yesAdvanced Science, EarlyView.
CSPG4 is identified as a high‐value, stemness‐associated target in HPV‐negative HNSCC. By implementing rational biophysical engineering, a humanized and charge‐optimized CAR is developed to overcome tonic signaling‐induced exhaustion. This strategy induces a profound transcriptomic shift toward a rejuvenated, stem‐like memory state, significantly ...
Xiang Xu   +13 more
wiley   +1 more source

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