Results 51 to 60 of about 1,003,896 (335)
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Current Research in Food ScienceMetabolic dysfunction-associated steatotic liver disease (MASLD) is recognized as one of the most common chronic liver conditions globally, presenting a significant public health. Probiotics, as modulators of intestinal microbiota, have emerged attention
Jing Lu +10 more
doaj +1 more source
Smart Grid Projects Outlook 2014 [PDF]
, 2014 Smart grid projects are playing a key role in shedding light on how to move forward in this challenging transition. In 2011, therefore, the JRC launched the first comprehensive inventory of smart grid projects in Europe to collect lessons learned and ...
AMOIRALIS Eleftherios +5 more
core +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Evaluating the operational and the environmental benefits of a smart roundabout
South African Journal of Industrial Engineering, 2015 Vehicle fuel consumption and emission rates in Kuwait have increased considerably over recent decades, and are now causing health and economic problems.
Alkhaledi, Khaled Ali
doaj +1 more source
Leveraging Circular Economy through a Methodology for Smart Service Systems Engineering [PDF]
, 2019 Product Service Systems (PSS) and Smart Services are powerful means for deploying Circular Economy (CE) goals in industrial practices, through dematerialization, extension of product lifetime and efficiency increase by digitization.
Halstenberg, Friedrich A. +2 more
core +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Ultra-robust informational metasurfaces based on spatial coherence structures engineering
Light: Science & ApplicationsOptical information transmission is vital in modern optics and photonics due to its concurrent and multi-dimensional nature, leading to tremendous applications such as optical microscopy, holography, and optical sensing.
Leixin Liu +7 more
doaj +1 more source
Achromatic diffractive liquid-crystal optics for virtual reality displays
Light: Science & Applications, 2023 Diffractive liquid-crystal optics is a promising optical element for virtual reality (VR) and mixed reality as it provides an ultrathin formfactor and lightweight for human factors and ergonomics.
Zhenyi Luo +4 more
doaj +1 more source
Engineering Cooperative Smart Things based on Embodied Cognition
, 2017 The goal of the Internet of Things (IoT) is to transform any thing around us, such as a trash can or a street light, into a smart thing. A smart thing has the ability of sensing, processing, communicating and/or actuating. In order to achieve the goal of
de Lucena, Carlos Jose Pereira +1 more
core +1 more source