Results 51 to 60 of about 1,193,594 (294)

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Broadband metamaterial absorber with enhanced angular stability using characteristic mode analysis

Results in Engineering
The integration of broadband functionality, polarization insensitivity, angular stability, and low-profile design in metamaterial (MM) absorbers remains a significant challenge. This study introduces a novel design approach utilizing characteristic mode (
Junfei Gao, Xiaojun Huang, Qi Xue, Lina Gao, Yutao Ma, Linyan Guo   +5 more
doaj   +1 more source

Current status and development trend of UAV remote sensing applications in the mining industry

工程科学学报, 2020
Unmanned aerial vehicle (UAV) remote sensing is a state-of-the-art technology that integrates UAV, remote sensing sensor, GPS differential positioning, communication, and other technologies to achieve rapid collection, processing, and analysis of ...
Kun WANG, Peng YANG, Wen-sheng LÜ, Li-yi ZHU, Guang-ming YU   +4 more
doaj   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

SMART-Plant project poster

, 2016
Scale-up of low-carbon footprint MAterial Recovery Techniques in existing wastewater treatment PLANTs SMART-plant aims to support the water sector to improve and ensure environmental protection, become more adaptive, and respond to contemporary ...
SMART-Plant Consortium, SMART-Plant Consortium (5292223)   +1 more
core   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

SMART-Plant project flyer (H2020)

, 2016
Scale-up of low-carbon footprint MAterial Recovery Techniques in existing wastewater treatment PLANTs SMART-plant aims to support the water sector to improve and ensure environmental protection, become more adaptive, and respond to contemporary ...
SMART-Plant Consortium, SMART-Plant Consortium (5292223)   +1 more
core   +1 more source

Development of an artificial intelligence based occupational noise induced hearing loss early warning system for mine workers

Frontiers in Neuroscience
IntroductionOccupational Noise Induced Hearing Loss (ONIHL) is one of the most prevalent conditions among mine workers globally. This reality is due to mine workers being exposed to noise produced by heavy machinery, rock drilling, blasting, and so on ...
Milka C. I. Madahana, John E. D. Ekoru, Ben Sebothoma, Katijah Khoza-Shangase   +3 more
doaj   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source