Results 41 to 50 of about 2,798 (212)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

In Vitro and In Silico Evaluations of Boswellia carterii Resin Dermocosmetic Activities

Cosmetics, 2022
Boswellia carterii is a plant species belonging to the Burseraceae family. It grows up in trees or shrubs, and it is known for producing an aromatic resin commonly named frankincense or olibanum.
Sohaib Hourfane, Hicham Mechqoq, Fatima Errajouani, João Miguel Rocha, Noureddine El Aouad   +4 more
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Realizing Networks of Proactive Smart Products [PDF]

, 2012
The sheer complexity and number of functionalities embedded in many everyday devices already exceed the ability of most users to learn how to use them effectively. An approach to tackle this problem is to introduce ‘smart’ capabilities in technical products, to enable them to proactively assist and co-operate with humans and other products.
Mathieu d'Aquin, Enrico Motta, Andriy Nikolov, Keerthi Thomas   +3 more
openaire   +1 more source

Correlation analysis between artemisinin and its derivative contents and trichome characteristics from different Artemisia species

Applied Biological Chemistry
Artemisia species have significant commercial, medical, and economic value and are widely used in the traditional medicine and pharmaceutical industries. Artemisinin, a powerful antimalarial agent, is an important pharmaceutical metabolite that primarily
Yun Ji Park, To Quyen Truong, Yeong Bin Choi, Phuong Kim Huynh, Jinyoung Moon, Song Yi Koo, Hyoung Seok Kim, Sang Min Kim   +7 more
doaj   +1 more source

Services on Platform Ecosystems in the Smart Home 2.0 Era: Elements Influencing Consumers’ Value Perception for Smart Home Products

Sensors, 2021
Recently, smart home products have shown signs of rapid development and increasing awareness of smart home platforms. In order to make smart home enterprises enter the era of Smart Home 2.0, it is necessary to consider the elements related to smart home ...
Ruiyang Tang, Yuki Inoue
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Development and application of a high-performance liquid chromatography diode-array detection (HPLC–DAD) method for the simultaneous quantification of phenolic compounds in the aerial part of Glehnia littoralis

Applied Biological Chemistry
Glehnia littoralis, a medicinal herb employed in traditional practices for alleviating fatigue, cough, and a dry throat, is recognized for its beneficial properties due to a diverse array of active compounds found in its extracts.
Yun Ji Park, Yeong Bin Choi, Sang-Bin Oh, Jinyoung Moon, To Quyen Truong, Phuong Kim Huynh, Sang Min Kim   +6 more
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source