Results 41 to 50 of about 863,067 (282)

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

open access: yesMolecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner   +14 more
wiley   +1 more source

The EU Sanctions Policy: A Thorny Path of Transformation

open access: yesВестник Московского Университета. Серия XXV: Международные отношения и мировая политика
In recent years, the rising international tensions have raised for the EU leadership pressing questions on the prospects for both the internal development of the union and its global positioning.
L. D. Oganisyan
doaj   +1 more source

Prospects for digitalization of sustainable development projects in the Russian Federation

open access: yesВестник университета, 2023
Green bonds have become the most notable innovations in the field of sustainable financing over the past 10 years. The article discusses the problems of issuing and circulation of such financial market instruments, examines the opportunities that modern ...
I. V. Pashkovskaya   +3 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

How to Ensure Consumer Safety for Unbranded Refill Drinking Water Depots?

open access: yesJournal of Consumer Sciences, 2023
Drinking water is water that has been processed to meet health standard regulations. However, some water can be consumed directly without several processes if it meets health safety requirements.
Anna Maria Tri Anggraini
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

open access: yesMolecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller   +10 more
wiley   +1 more source

Sanctions and South Africa [PDF]

open access: yes, 1995
This thesis studies sanctions and South Africa to show that sanctions can be an effective instrument of foreign policy. It provides a general study on sanctions and South Africa that is not limited to economic factors alone.
Wilson, Jeya., Wilson, Jeya
core   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

open access: yesMolecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas   +16 more
wiley   +1 more source

SMART SANCTIONS AS AN ALTERNATIVE TO INTERNATIONAL ECONOMIC SANCTIONS WITHIN THE FRAMEWORK OF PUBLIC INTERNATIONAL LAW

open access: yesRIMAK International Journal of Humanities and Social Sciences, 2022
Smart economic sanctions are the reaction of the international community and the United Nations to the bad results in respect of human rights brought by the traditional comprehensive international economic sanctions, and it is also a response to the bad economic results achieved by those sanctions.
openaire   +1 more source

How Effective Are Unemployment Benefit Sanctions? Looking Beyond Unemployment Exit [PDF]

open access: yes
This paper provides a comprehensive evaluation of benefit sanctions, i.e. temporary reductions in unemployment benefits as punishment for noncompliance with eligibility requirements.
Lalive, Rafael   +2 more
core   +4 more sources

Home - About - Disclaimer - Privacy