Results 31 to 40 of about 8,808 (262)

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Smart Transformer-Assisted Frequency Control Mechanism for RES Penetrated Power Systems Considering Metaheuristic-Based Secondary Controller

Energies
The gradual replacement of conventional generators with variable renewable energy sources (RES) will reduce their online frequency regulation (FR) resources and degrade their overall frequency control capabilities.
Chakka Bapi Ayyappa Raju, Sanjoy Debbarma, Rayapudi Srinivasa Rao   +2 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Active Hybrid Solid State Transformer Based on Multi-Level Converter Using SiC MOSFET

Energies, 2018
As the types of loads have been diversified and demand has increased, conventional distribution transformers are difficult to maintain the constant voltage against voltage drop along with distance, grid voltage swell/sag, and various loads.
Chun-gi Yun, Younghoon Cho
doaj   +1 more source

Smart Transformer

Power distribution transformers are key infrastructural elements whose operational failure introduces network instability, high repair liabilities, and customer power disruptions. Standard manual maintenance schemes cannot prevent rapid failures caused by overloading and unexpected thermal spikes in real time.
Jaydip Shirsath, Saurabh Bhalerao, Chintamani Bonde, Prathamesh Waghmare, Prof. Shruti Gour   +4 more
openaire   +2 more sources

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

An AI-Layered with Multi-Agent Systems Architecture for Prognostics Health Management of Smart Transformers: A Novel Approach for Smart Grid-Ready Energy Management Systems

Energies, 2022
After the massive integration of distributed energy resources, energy storage systems and the charging stations of electric vehicles, it has become very difficult to implement an efficient grid energy management system regarding the unmanageable behavior
Oussama Laayati, Hicham El Hadraoui, Adila El Magharaoui, Nabil El-Bazi, Mostafa Bouzi, Ahmed Chebak, Josep M. Guerrero   +6 more
doaj   +1 more source

Smart Transformations: The Evolution of Choice Principles

CoRR, 2015
Evolutionary game theory classically investigates which behavioral patterns are evolutionarily successful in a single game. More recently, a number of contributions have studied the evolution of preferences instead: which subjective conceptualizations of a game's payoffs give rise to evolutionarily successful behavior in a single game. Here, we want to
Paolo Galeazzi, Michael Franke
openaire   +3 more sources

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source