Results 91 to 100 of about 98,726 (164)

Update on cellular expression and function of ANO1 channels in urethral smooth muscle

The Journal of Physiology, EarlyView.
Abstract figure legend Activation of ANO1 channels and resulting Cl− efflux are suggested to modulate urethral smooth muscle contractility by enhancing Ca2+ influx via voltage‐dependent Ca2+ entry and resulting contraction in urethral smooth muscle cells.
Bernard T. Drumm, Neha Gupta
wiley   +1 more source

In the gravid human uterus, oxytocin induces smooth muscle cell contraction via transient receptor potential vanilloid 4 channel activation

The Journal of Physiology, EarlyView.
Abstract figure legend In gravid human uterus smooth muscle, the oxytocin receptor (OXTR) and transient receptor potential vanilloid 4 (TRPV4) calcium channel colocalize at <40 nm by proximity ligation. TRPV4 is necessary for oxytocin‐induced calcium influx and contractility in uterine smooth muscle cells.
Daiana Fornes, Jessica R. Ansari, Guillermina Michel, Cristina M. Alvira, David N. Cornfield   +4 more
wiley   +1 more source

Improving Operator Depth Vision in Gastrointestinal Endoscopy: A Pilot Study of a New Three‐dimensional Imaging System

DEN Open, Volume 6, Issue 1, April 2026.
ABSTRACT Background and aims Traditional two‐dimensional (2D) gastrointestinal endoscopy lacks depth perception, leading to potential diagnostic errors. This study evaluates a novel software‐based three‐dimensional (3D) endoscopy system that converts 2D images into 3D, compatible with existing endoscopes.
Xiaoqing Lin, Kohei Ono, Ken Ohata, Etsuko Yamabe, Hidenori Eida, Miyuzen Kanamori, Naoki Tomita, Toshifumi Iida, Susumu Banjoya, Tomoya Kimura, Hiroshi Yamazaki, Koichi Furuta, Nao Takeuchi, Yoshiaki Kimoto, Yuki Kano, Yohei Minato, Shunya Takayanagi, Shinya Nagae, Yohei Ito, Ryoju Negishi, Eiji Sakai, Hideyuki Chiba, Zhen Ding   +22 more
wiley   +1 more source

Spatial Distribution of Parthenium hysterophorus: Impact on Plant Species Diversity and Soil Characteristics in Gamo Zone, Southern Ethiopia

Plant-Environment Interactions, Volume 7, Issue 2, April 2026.
ABSTRACT The invasions are severe and have an impact on pasture lands, farmlands, and conservation areas. However, there is little data on Parthenium hysterophorus L. (Parthenium) mapping using GIS in the Southern Region of Ethiopia. The objective of this study was to map the spatial distribution of Parthenium which affects the diversity of plant ...
Wakshum Shiferaw, Yohannes Golida, Gedamu Yenew, Berhanu Lemma   +3 more
wiley   +1 more source

ZNF384‐Driven Fibulin‐1 Exacerbates Vascular Stiffness via TGF‐β/Smad3‐Mediated Senescence and Fibrosis

The FASEB Journal, Volume 40, Issue 6, 31 March 2026.
This article elucidates the regulatory molecular mechanisms of Fibulin‐1 (Fbln1) in vascular stiffness and explores potential therapeutic interventions. Zinc Finger Protein 384 (ZNF384) binds to the Fbln1 promoter, driving its expression. Fbln1 activates the TGF‐β/Smad3 axis, promoting vascular smooth muscle cell (VSMC) senescence and collagen ...
Dan Yan, Tianyi ji, Xiaolu Liang, Mandi Luo, Yi Huang, Pengcheng Luo, Zhen Yang, Le Zhang, Tao Li, Yong Ping Bai, Cuntai Zhang, Lei Ruan   +11 more
wiley   +1 more source

Aerobic Exercise Ameliorates Adverse Vascular Remodeling in Diabetes via PDK1/FoxO1 Axis

The FASEB Journal, Volume 40, Issue 6, 31 March 2026.
Reduced PDK1 expression in the carotid arteries of type 1 diabetic mice promotes abnormal FoxO1 expression, thereby inducing inflammatory responses and vascular remodeling. These phenotypes can be ameliorated by regular aerobic exercise. In vitro experiments further confirm that the PDK1‐FoxO1 signaling axis in a high‐glucose environment can induce ...
Xiang Xie, Zihan Zhang, Xumei Yang, Man Chu   +3 more
wiley   +1 more source

Advancing the Landscape of RNAi Nanotherapeutics for Ischemic Heart Disease

Advanced Materials, Volume 38, Issue 17, 20 March 2026.
RNA interference (RNAi) nanomedicine revolutionizes treatment regimens for ischemic heart diseases by enabling tailored, sequence‐anchored gene regulation. This review highlights the recent advances in nanotechnology‐driven RNAi therapeutics for myocardial ischemia and discusses the key design principles that govern efficient delivery, providing ...
Han Gao, Da Pan, Hélder A. Santos
wiley   +1 more source

Decoding the Cellular Heterogeneity and Malignant Progression of Human Penile Squamous Cell Carcinoma by Single‐Cell RNA Sequencing

Advanced Science, Volume 13, Issue 14, 9 March 2026.
Single‐cell transcriptomic and functional analyses identify SEMA3C as a key regulator of tumor progression and tumor microenvironment remodeling in penile squamous cell carcinoma. SEMA3C promotes epithelial–mesenchymal transition, tumor growth, and invasion while shaping an immunosuppressive microenvironment, highlighting its potential as a prognostic ...
Xiheng Hu, Wensheng Shi, Liang Dong, Lingjuan Huang, Xiyuan Zhang, Yiting Feng, Jie Sun, Lanlan Liu, Teng Liu, Jun Fu, Bowen Zhong, Qihao Leng, Xiaohua Wu, Minfeng Chen, Lingfang Li, Yuan Li, Xin Jin, Long Wang, Jian Cao, Xin Li, Mingzhu Yin, Xiang Chen   +21 more
wiley   +1 more source

NFS1 Regulates IDH2 to Attenuate Abdominal Aortic Aneurysms via Interacting With SP2

Advanced Science, Volume 13, Issue 14, 9 March 2026.
The loss of NFS1 leads to its reduced binding with the transcription factor SP2, resulting in decreased expression of the downstream gene Idh2. This causes a shift in energy supply toward glycolysis in VSMCs, ultimately contributing to the occurrence and progression of AAA.
Luzheng Zhang, Yu Zhang, Dezhong Wen, Suxiang Guo, Xiaohui Qi, Heng Wang, Yujin Sun, Guangdong Yang, Yuehong Wang, Song Xue   +9 more
wiley   +1 more source

Summer‐dormant, perennial groundcover has minimal effect on plant‐available nutrients and no effect on maize yield

Agronomy Journal, Volume 118, Issue 2, March/April 2026.
Abstract Conventional agriculture in the US Midwest has accelerated crop productivity but also contributed to undesirable environmental issues. Perennial groundcovers (PGCs), such as cool‐season grasses intercropped in the maize (Zea mays L.) interrow, have the potential to reduce soil erosion rates and mitigate nutrient losses.
P. D. Galland, C. R. Dutter, A. Chen, M. D. McDaniel, K. J. Moore, A. Thoms, S. Z. Fei   +6 more
wiley   +1 more source