Results 131 to 140 of about 4,318,497 (351)

Autophagy Activators Normalize Aberrant Tau Proteostasis and Rescue Synapses in Human Familial Alzheimer's Disease iPSC‐Derived Cortical Organoids

Advanced Science, EarlyView.
A new cerebrocortical organoid model using isogenic hiPSCs with familial Alzheimer's mutations recapitulates key AD features, including amyloid‐beta and phospho‐Tau aggregation, neuronal hyperexcitability, and synapse loss. Single‐cell RNA‐seq reveals aberrant pathways in excitatory and inhibitory neurons.
Sergio R. Labra, Jadon Compher, Akhil Prabhavalkar, Mireya Almaraz, Claudia Cedeño Kwong, Christine Baal, Maria Talantova, Nima Dolatabadi, Julian Piña‐Sanz, Yubo Wang, Leonard Yoon, Swagata Ghatak, Zi Gao, Yuting Zhang, Dorit Trudler, Lynee Massey, Wei Lin, Anthony Balistreri, Michael Bula, Nicholas J. Schork, Tony S. Mondala, Steven R. Head, Jeffery W. Kelly, Stuart A. Lipton   +23 more
wiley   +1 more source

Finite size and intrinsic field effect on the polar-active properties of the ferroelectric-semiconductor heterostructures

, 2009
Using Landau-Ginzburg-Devonshire approach we calculated the equilibrium distributions of electric field, polarization and space charge in the ferroelectric-semiconductor heterostructures containing proper or incipient ferroelectric thin films.
A. D. Krutov, A. N. Morozovska, A. Y. Borisevich, E. A. Eliseev, G. A. Smolenskii, H. Y. Hwang, J. F. Scott, M. A. Itskovsky, P. Maksymovych, S. M. Sze, S. V. Kalinin, S. V. Svechnikov, V. M. Fridkin, V. Y. Shur   +13 more
core   +1 more source

Scanning electron microscopic evaluation of smear layer removal at the apical third of root canals using diode laser, endoActivator, and ultrasonics with chitosan: An in vitro study

Journal of Conservative Dentistry, 2019
Aim: The aim of this study was to compare the effect of diode laser, endoActivator, and passive ultrasonics for smear layer removal at the apical third from root canals with 0.2% chitosan.
S. Abraham, S. Vaswani, H. Najan, Disha Mehta, A. Kamble, S. Chaudhari   +5 more
semanticscholar   +1 more source

Irgm1 Improves Postinfarction Cardiac Repair by Promoting Neutrophil Clearance and Efferocytosis

Advanced Science, EarlyView.
The Irgm1‐PDIA3 axis enhances post‐infarction cardiac repair by accelerating neutrophil clearance and facilitating efferocytosis. Irgm1 holds potential as a prognostic biomarker in MI, and LOC14 may represent a therapeutic option to improve cardiac repair, especially in cases of Irgm1 deficiency.
Zeng Wang, Lai Wei, Mingyang Wang, Shanjie Wang, Lili Xiu, Jiaxiang Sun, Rongzhe Lu, Yige Liu, Jiaxin Wang, Fengyi Liu, Weike Liu, Bo Yu, Yong Sun, Xueqin Gao, Shaohong Fang   +14 more
wiley   +1 more source

Laser‐Induced Ultrafast Magnetic Phase Transition in 2D Van Der Waals Antiferromagnetic Heterostructures

Advanced Science, EarlyView.
In this work, ultrafast laser‐induced spin transfer and spin relaxation dynamics in 2D van der Waals antiferromagnetic CrI3/CrGeTe3 heterostructures are investigated. Laser excitation is demonstrated to induce pronounced interlayer nonequilibrium spin dynamics and ultrafast magnetic moment reconstruction, driving a transition from an antiferromagnetic (
Yang Wu, Fulu Zheng, San‐Dong Guo, Thomas Frauenheim, Zhaobo Zhou, Junjie He   +5 more
wiley   +1 more source

Large Broadening of the Superconducting Transition by Fluctuations in a 3D Metal at High Magnetic Fields: The MgB$_{2}$ case

, 2004
It is shown that the transition to the low temperature superconducting state in a 3D metal at high magnetic field is smeared dramatically by thermal fluctuation of the superconducting order parameter.
B. Bergk, D. Bintley, G. Goll, J. Wosnitza, L. D. Landau, O. Ignatchik, O. Ignatchik, P. C. Canfield, T. Maniv, V. Zhuravlev   +9 more
core   +1 more source

In vitro effect of XP-Endo finisher on the amount of residual debris and smear layer on the root canal walls

Dental Research Journal, 2019
Background: A successful endodontic treatment depends on efficient cleaning and shaping and effective irrigation of root canals. The irrigating solution may not be effective in some areas in the canal.
Shahrzad Azimian, H. Bakhtiar, S. Azimi, E. Esnaashari   +3 more
semanticscholar   +1 more source

A Deep Representation Learning Method for Quantitative Immune Defense Function Evaluation and Its Clinical Applications

Advanced Science, EarlyView.
ImmuDef, a novel algorithm to quantitatively evaluate the anti‐infection immune defense function of an individual based on RNA‐seq data via a variational autoencoder (VAE) model. It is validated on 3200+ samples across four immune states with high accuracy. It can serve as a metric for disease severity and prognosis across pathogenic cohorts.
Zhen‐Lin Tan, Tao Luo, Yu Lin, Xiao‐Jun Wu, Wen‐Kang Shen, Jie Chen, Qian Lei, An‐Yuan Guo   +7 more
wiley   +1 more source

Oscillations of the superconducting critical current in Nb-Cu-Ni-Cu-Nb junctions

, 2002
We report on experimental studies of superconductor-ferromagnet layered structures. Strong oscillations of the critical supercurrent were observed with the thickness variation of the ferromagnet.
A. Palevski, A. Tsukernik, A. D. Zaikin, A. D. Zaikin, A. I. Buzdin, A. I. Buzdin, A. I. Buzdin, A. I. Buzdin, A. L. Gudkov, A. L. Gudkov, H. Courtois, L. N. Bulaevskii, L. N. Bulaevskii, M. Karpovski, T. T. Heikkilä, Y. Blum, Y. Obi   +16 more
core   +1 more source

Smear Layer Removal and Microhardness Alteration Potential of a Naturally Occurring Antioxidant – An In Vitro Study

Cureus, 2019
Introduction: It is well-known in the field of endodontics that the presence of a smear layer in the root canals can harbor bacteria and limit the penetration of irrigating solutions and intracanal medications into the dentinal tubules which, in turn ...
Arasappan Rajakumaran, Hasini Ramesh, Rupa Ashok, Lakshmi Balaji, A. Ganesh   +4 more
semanticscholar   +1 more source