Results 211 to 220 of about 78,135 (298)

Precision therapies for genetic epilepsies in 2025: Promises and pitfalls

Epilepsia Open, EarlyView.
Abstract By targeting the underlying etiology, precision therapies offer an exciting paradigm shift to improve the stagnant outcomes of drug‐resistant epilepsies, including developmental and epileptic encephalopathies. Unlike conventional antiseizure medications (ASMs) which only treat the symptoms (seizures) but have no effect on the underlying ...
Shuyu Wang, Emilio Perucca, Samuel F. Berkovic, Piero Perucca   +3 more
wiley   +1 more source

Evaluation of a novel eHealth-facilitated, post HCT-integrated care model on implementation and rehospitalization: results from the Swiss SMILe hybrid-RCT. [PDF]

Bone Marrow Transplant
Valenta S, Ribaut J, Denhaerynck K, Leppla L, Teynor A, Gerull S, Halter J, Passweg J, Eckstein J, Simon M, De Geest SM.   +10 more
europepmc   +1 more source

Optimizing polytherapy management for Dravet syndrome in the United States: A National Expert Consensus

Epilepsia Open, EarlyView.
ABSTRACT Objectives Dravet syndrome (DS) is a severe, drug‐resistant developmental and epileptic encephalopathy (DEE) that requires polytherapy for adequate seizure control. The need to combine multiple antiseizure medications (ASMs), together with variability in seizure types, safety considerations, and evolving patient needs, makes treatment ...
Elaine Wirrell, Joseph Sullivan
wiley   +1 more source

Frequency-dependent associations of contrast sensitivity and corneal aberrations after SMILE PRO in eyes with high astigmatism. [PDF]

Front Med (Lausanne)
Tran LHT, Tran TN, Cung HS, Tran SK, Pham VT.   +4 more
europepmc   +1 more source

Changes in effectiveness and safety in patients with Lennox–Gastaut syndrome transitioning from the fenfluramine randomized controlled trial to open‐label extension study

Epilepsia Open, EarlyView.
This graphical abstract provides an overview of the content from this post hoc analysis describing the trajectories of fenfluramine effectiveness and safety, along with dose changes over time, in patients with Lennox‐Gastaut syndrome. Abstract In the phase 3 randomized controlled trial (RCT; NCT03355209) of fenfluramine in Lennox–Gastaut syndrome (LGS),
Rima Nabbout, Orrin Devinsky, Lieven Lagae, Ingrid E. Scheffer, Renzo Guerrini, Joseph Sullivan, Antonio Gil‐Nagel, Sameer M. Zuberi, Kate Riney, Patrick Healy, Jayne Abraham, Rebecca Zhang Roper, Mélanie Langlois, Amélie Lothe, Kelly G. Knupp   +14 more
wiley   +1 more source

Slow granular corneal dystrophy type 2 exacerbation after SMILE: a bilateral asymmetric case resembling a unique previous unilateral case. [PDF]

Int J Ophthalmol
Yoon SH, Kim SJ, Min JS, Kim TI, Stulting RD, Jun I, Kim EK.   +6 more
europepmc   +1 more source

Efficacy and safety of fenfluramine in Dravet syndrome: The impact of patient clinical characteristics

Epilepsia Open, EarlyView.
This graphical abstract provides an overview of the content from this post hoc analysis evaluating the efficacy and safety of fenfluramine in patients with Dravet syndrome stratified by age, number of previously attempted antiseizure medications, and SCN1A pathogenic variant status using data pooled from the three pivotal randomized controlled trials ...
Rima Nabbout, Joseph Sullivan, Stéphane Auvin, J. Helen Cross, Orrin Devinsky, Antonio Gil‐Nagel, Renzo Guerrini, Kelly G. Knupp, M. Scott Perry, Rocío Sánchez‐Carpintero, An‐Sofie Schoonjans, Ingrid E. Scheffer, Nicola Specchio, Adam Strzelczyk, James Wheless, Elaine C. Wirrell, Diego Morita, Patrick Healy, Mélanie Langlois, Amélie Lothe, Lieven Lagae   +20 more
wiley   +1 more source

Aftasten/Tantear: A sensorial, coalitional wayfinding among Muslim runners

Feminist Anthropology, EarlyView.
Abstract Muslim recreational runners in Muslim‐minority settings that take up running as their preferred form of leisure indicate that they feel they have to navigate a sense of exclusion when running outdoors. This article explores the process of exploration and sensing in public, represented by the Dutch verb aftasten, to investigate the way Muslim ...
Jasmijn Rana
wiley   +1 more source

Influence of incisor display and lower lip height on smile esthetics and perceived age. [PDF]

Dental Press J Orthod
Russo JDES, Bittencourt RC, Barros DMC, Almeida RP, Lorenzoni DC, Mota-Júnior SL, Mattos CT.   +6 more
europepmc   +1 more source

Encountering anthropologists through body‐mapping: On risk‐taking, experimentation and solidarity in the neoliberal university

Feminist Anthropology, EarlyView.
Abstract This article turns a workshop session and the university as a locus of knowledge production into objects of ethnographic investigation. The authors reflect on our experience co‐facilitating a body‐mapping session with a group of anthropologists of different backgrounds, ages and career stages—all women—from universities across Europe, during a
Koreen M. Reece, Magdalena Suerbaum
wiley   +1 more source