Results 81 to 90 of about 594,620 (381)

Dipiperazine‐Phenyl Derivatives Based on Convergent Molecular Platforms Can Reverse Multidrug Resistance in Gram‐Negative Bacteria by Inhibiting Efflux and Permeabilizing Cell Membranes

Advanced Science, EarlyView.
By integrating a convergent molecular platform strategy, this study designed a novel dual‐target C5 to combat multidrug‐resistant Gram‐negative bacteria. C5 synergistically enhances antibiotic efficacy by inhibiting efflux pumps and increasing bacterial membrane permeability.
Jiale Dong, Ting Guo, Yi Huang, Yangchun Ma, Weijin Chen, Jie Xue, Jun Jiang, Enhui Dong, Yue Kong, Hang Ding, Wenlong Zhang, Shutao Ma   +11 more
wiley   +1 more source

Intraocular lens power calculation using total keratometry and ray tracing in eyes with previous small incision lenticule extraction – A case series

American Journal of Ophthalmology Case Reports
Purpose: To assess the IOL power calculation accuracy in post-SMILE eyes using ray tracing and a range of total keratometry based IOL calculation formulae. Observations: Ray tracing showed excellent predictability in IOL power calculation after SMILE and
Roman Lischke, Rainer Wiltfang, Martin Bechmann, Thomas C. Kreutzer, Siegfried G. Priglinger, M. Dirisamer, Nikolaus Luft   +6 more
doaj   +1 more source

Corneal Biomechanical Changes and Tissue Remodeling After SMILE and LASIK.

Investigative Ophthalmology and Visual Science, 2017
Purpose To evaluate transient corneal tissue healing and biomechanical changes between laser in situ keratomileusis (LASIK) and small incision lenticule extraction (SMILE) eyes.
R. Shetty, Mathew Francis, Rushad Shroff, Natasha Pahuja, P. Khamar, Molleti Girrish, R. Nuijts, Abhijit Sinha Roy   +7 more
semanticscholar   +1 more source

DualPG‐DTA: A Large Language Model‐Powered Graph Neural Network Framework for Enhanced Drug‐Target Affinity Prediction and Discovery of Novel CDK9 Inhibitors Exhibiting in Vivo Anti‐Leukemia Activity

Advanced Science, EarlyView.
This study introduces DualPG‐DTA, a framework integrating two pre‐trained models to generate molecular and protein representations. It constructs dual graphs processed by specialized neural networks with dynamic attention for feature fusion, achieving superior benchmark performance.
Yihao Chen, Jindi Huang, Cong Liu, Shipeng Zhang, Xinze Li, Zhang Zhang, Tie‐Gen Chen, Ling Wang   +7 more
wiley   +1 more source

Students Collaboratively Prompting ChatGPT

Computers
This study investigated how undergraduate students collaborated when working with ChatGPT and what teamwork approaches they used, focusing on students’ preferences, conflict resolution, reliance on AI-generated content, and perceived learning outcomes ...
Maria Perifanou, Anastasios A. Economides   +1 more
doaj   +1 more source

Smile detection in the wild based on transfer learning

, 2018
Smile detection from unconstrained facial images is a specialized and challenging problem. As one of the most informative expressions, smiles convey basic underlying emotions, such as happiness and satisfaction, which lead to multiple applications, e.g.,
Barner, Kenneth E., Guo, Xin, Polanía, Luisa F.   +2 more
core   +1 more source

Digital smile design for gummy smile correction

Indian Journal of Dental Research, 2019
Some tools can be used as an aid to the surgical planning for gummy smile correction, such as digital smile design (DSD), which allows to determine patterns of harmony and eventual asymmetries between teeth and gums. This work aims to report a gummy smile correction using DSD as reverse planning.
Yara Loyanne de A S. Levi, Letícia Vitória de S. Cota, Luciana P Maia   +2 more
openaire   +3 more sources

Ectasia following small-incision lenticule extraction (SMILE): a review of the literature

Clinical Ophthalmology, 2017
Purpose Four cases of corneal ectasia after small-incision lenticule extraction (SMILE) have been reported. In this review, we provide an overview of the published literature on corneal ectasia after SMILE and risk factors associated with this ...
M. Moshirfar, Julio C Albarracin, Jordan D. Desautels, Orry C. Birdsong, S. Linn, P. Hoopes   +5 more
semanticscholar   +1 more source

Dual Targeting of Tau Kinases and Autophagy by Abemaciclib Independent of CDK4/6 Inhibition

Advanced Science, EarlyView.
Abemaciclib rescues cognitive function and attenuates tau pathology in Alzheimer's disease models, but not through its known cancer‐fighting mechanism. This study demonstrates that abemaciclib operates independently of CDK4/6 inhibition, instead directly targeting tau kinases CaMKII and GSK3β while simultaneously promoting autophagic clearance of ...
Jihui Han, June‐Hyun Jeong, Dongjoon Lee, Yujin Jung, Yujin Jin, Eun Sun Jung, Haeng Jun Kim, Woo Youn Kim, Chang‐Han Lee, Inhee Mook‐Jung   +9 more
wiley   +1 more source

Collaborative Uses of GenAI Tools in Project-Based Learning

Education Sciences
Artificial intelligence (AI) is forcing a dramatic transformation of the methods by which we acquire knowledge and engage in collaborative learning. Although there are several studies on how AI can support collaborative learning, there are no published ...
Maria Perifanou, Anastasios A. Economides   +1 more
doaj   +1 more source