Results 181 to 190 of about 2,634,989 (242)

Antiseizure potency and neurotoxicity of the enantiomers of fenfluramine and norfenfluramine in rats and correlations with their concentrations in plasma and brain

Epilepsia, EarlyView.
Abstract Objective Based on the evidence that fenfluramine‐induced anorexia, weight loss, and cardiovascular toxicity are primarily mediated by the d‐enantiomers of fenfluramine and its metabolite norfenfluramine, we investigated pharmacokinetic/pharmacodynamic correlations for the active enantiomers of fenfluramine and norfenfluramine in the rat ...
Yara Sheeni, Dinorah Barasch, Tawfeeq Shekh‐Ahmad, Emilio Perucca, Meir Bialer   +4 more
wiley   +1 more source

Symptom distress evolution over the first year after allogeneic stem cell transplantation - a prospective observational sub-study of the SMILe project. [PDF]

Support Care Cancer
Schmid A, Ribaut J, De Geest SM, Valenta S, Zeiser R, Denhaerynck K, Kaier K, Teynor A, Leppla L.   +8 more
europepmc   +1 more source

Outcomes of out‐of‐hospital treatment of impending tonic–clonic status epilepticus with diazepam nasal spray: A retrospective combined cohort analysis

Epilepsia, EarlyView.
Abstract Objective We assessed the timing, dosing, and effectiveness of diazepam nasal spray in a large dataset of seizures treated in the out‐of‐hospital setting, using as reference the International League Against Epilepsy criteria for tonic–clonic status epilepticus (SE) and its treatment.
John M. Stern, Leock Y. Ngo, Eric B. Segal, Danielle A. Becker, Randa G. Jarrar, Tracy A. Glauser, Jurriaan M. Peters, Emilio Perucca, Evelyn K. Shih, Enrique Carrazana, Adrian L. Rabinowicz   +10 more
wiley   +1 more source

Digital smile design-driven minimally invasive lithium disilicate laminate veneers in the aesthetic zone: a 6-year follow-up case report. [PDF]

Front Dent Med
Dang AT, Nguyen APT, Le LTT, Pham HT, Bourgi R.   +4 more
europepmc   +1 more source

Real world testing and cost‐effectiveness analysis of subcutaneous EEG (REAL‐ASE): Protocol for a prospective multicentre interventional trial

Epilepsia Open, EarlyView.
Abstract Objective Epilepsy is a common condition associated with significant morbidity, mortality, and costs. Poor documentation of seizures is a major challenge in epilepsy care. Objective seizure counting with mobile devices may mitigate this challenge and improve patient management.
Matthew McWilliam, Pedro F. Viana, Eren Dursun, Joe Davies, Joel S. Winston, Jessica Agren, Harutomo Hasegawa, Jonas Duun‐Henriksen, Mark P. Richardson   +8 more
wiley   +1 more source

Digital Smile Design and Patient-Centered Outcomes in Esthetic Restorative Dentistry: A Systematic Review. [PDF]

Cureus
Alwabel LK, Alabduljabar WM, Alawfi LK, Al Johani NK, Alharbi LE, Kharif MA, Albahrani FD, Alarjani MB, Alzahrani MS, Alshammari AA, Alashjai A, Alanaz L.   +11 more
europepmc   +1 more source

Precision therapies for genetic epilepsies in 2025: Promises and pitfalls

Epilepsia Open, EarlyView.
Abstract By targeting the underlying etiology, precision therapies offer an exciting paradigm shift to improve the stagnant outcomes of drug‐resistant epilepsies, including developmental and epileptic encephalopathies. Unlike conventional antiseizure medications (ASMs) which only treat the symptoms (seizures) but have no effect on the underlying ...
Shuyu Wang, Emilio Perucca, Samuel F. Berkovic, Piero Perucca   +3 more
wiley   +1 more source

Ex Vivo Assessment of Excimer Laser-Assisted Lenticule Customization. [PDF]

Transl Vis Sci Technol
Abusayf MM, Han E, Liu YC, Riau AK, Mehta JS.   +4 more
europepmc   +1 more source

Optimizing polytherapy management for Dravet syndrome in the United States: A National Expert Consensus

Epilepsia Open, EarlyView.
ABSTRACT Objectives Dravet syndrome (DS) is a severe, drug‐resistant developmental and epileptic encephalopathy (DEE) that requires polytherapy for adequate seizure control. The need to combine multiple antiseizure medications (ASMs), together with variability in seizure types, safety considerations, and evolving patient needs, makes treatment ...
Elaine Wirrell, Joseph Sullivan
wiley   +1 more source

Case Report: A novel 3D-printed dual-matrix system for guided fabrication of indirect anterior composite veneers. [PDF]

Front Dent Med
Wirz F, Cáceres M, Arnés I, Durán Ojeda G.   +3 more
europepmc   +1 more source