Results 231 to 240 of about 250,300 (327)

Cost‐effectiveness of fenfluramine as add‐on treatment in the management of Dravet Syndrome: A real‐world multicenter study

Epilepsia Open, EarlyView.
Abstract Objective Dravet syndrome (DS) is a rare disease with a high clinical and socioeconomic impact on patients, society, and the healthcare system. The recent approval of therapies such as fenfluramine (FFA) has transformed the treatment landscape; however, data on their cost‐effectiveness are still scarce. This study evaluates the real‐world cost‐
Paolo A. Cortesi, Carla Fornari, Alessandra Boncristiano, Rita Facchetti, Simona Balestrini, Viola Doccini, Nicola Specchio, Nicola Pietrafusa, Marina Trivisano, Francesca Darra, Alberto Cossu, Domenica I. Battaglia, Michela Quintiliani, Maria L. Gambardella, Lorenzo G. Mantovani, Renzo Guerrini   +15 more
wiley   +1 more source

Enhancing deep chemical reaction prediction with advanced chirality and fragment representation.

Chem Commun (Camb)
Mastrolorito F, Ciriaco F, Nicolotti O, Grisoni F.   +3 more
europepmc   +1 more source

Fluorophore Design via Generative Modeling in a Curated Subspace. [PDF]

ACS Omega
Kim B, Ashyrmamatov I, Ucak UV, Lee J.
europepmc   +1 more source

Areas of research priorities in epilepsy: A position paper of the European Reference Network for Rare and Complex Epilepsies, EpiCARE

Epilepsia Open, EarlyView.
Abstract Objective To define and articulate research priorities in epilepsy identified by the European Reference Network for Rare and Complex Epilepsies (ERN EpiCARE), addressing key unmet needs across the spectrum of rare and complex epilepsies. Methods This position paper was developed through a structured collaborative process involving patient ...
Sébile Tchaicha, Stéphane Auvin, Sándor Beniczky, Andreas Brunklaus, Lieven Lagae, Emilio Perucca, Rainer Surges, Sophie Adler, Christoph Helmstaedter, Floor Jansen, Guido Rubboli, Philippe Ryvlin, Nicola Specchio, Eugen Trinka, Ingmar Blümcke, Valentina de Giorgis, Katarzyna Kotulska, Gaetan Lesca, Masa Malenica, Amy McTague, Rima Nabbout, Rikke Steensbjerre Møller, Sandra Silva Arrieta, Isabella Brambilla, Małgorzata Kosla, Kees Braun, J. Helen Cross, Alexis Arzimanoglou   +27 more
wiley   +1 more source

Machine-Readable Structural Information Is Essential for Natural Products Research. [PDF]

J Nat Prod
Steffen K, Oberlies NH, Rokas A.
europepmc   +1 more source

Reading the Smile: The Message Conveyed by Methods Which Infer Risk Neutral Densities

, 1997
Éric Jondeau, Michael Rockinger
openalex   +1 more source

Semiology in spontaneous versus cortical stimulation‐induced seizures during SEEG: A within‐patient comparison study

Epilepsia Open, EarlyView.
Abstract Objective We aimed to study the concordance of seizure semiology in direct electrical stimulation‐induced seizures (SIS) compared to spontaneous seizures during stereoelectroencephalography (SEEG) and to report on patient‐level variables associated with habitual and atypical SIS.
Marai Mahizhnan, Stéphane Dufau, John Phamnguyen, Arash Kahrom, Donald Craig, Aileen McGonigal   +5 more
wiley   +1 more source

MGF-DTA: A Multi-Granularity Fusion Model for Drug-Target Binding Affinity Prediction. [PDF]

Int J Mol Sci
Ni Z, Wei B, Zeng Y.
europepmc   +1 more source

“My Happiness Makes You Smile”: Beginning to Understand Telepathic Superpower Design Via Brain-Muscle Interfaces

Siyi Liu, Barrett Ens, Nathan Semertzidis, Gun Lee, Florian Mueller, Don Samitha Elvitigala   +5 more
openalex   +1 more source

Computer‐Aided Functional Oligosaccharide Screening and the Regulatory Role in Lipid Metabolism

Food Bioengineering, EarlyView.
ABSTRACT This study investigated the lipid‐lowering effects and intervention mechanisms of structurally diverse functional oligosaccharides on non‐alcoholic fatty liver disease (NAFLD). By integrating computational tools such as molecular docking and molecular dynamics simulations (MDS), a comprehensive “in silico‐in vitro‐in vivo” tri‐dimensional ...
Rui Jing, Shanshan Deng, Mengyao Zhao, Liming Zhao   +3 more
wiley   +1 more source