Results 211 to 220 of about 262,118 (350)

Quantitative Investigation of Nitrosamine Drug Substance‐Related Impurities (NDSRIs) Under Artificial Gastric Conditions by Liquid Chromatography–Tandem Mass Spectrometry and Structure–Activity Relationship Analysis

open access: yesDrug Testing and Analysis, EarlyView.
The study provides information about the impact of physiological gastric conditions on the unbeneficial occurrence of nitrosamine drug substance–related impurities (NDSRIs). Both main factors for nitrosation in the form of acidic conditions and the presence of nitrite were adequately chosen for triggering the conversion of drug compounds into NDSRIs ...
Matthias Vogel   +5 more
wiley   +1 more source

Horizon scanning of potential invasive alien plant species and their distribution in Norway under a changing climate

open access: yesEcography, EarlyView.
Invasive alien plant species can cause considerable ecological, economic, and social impacts, and the number of impactful species will likely increase with globalisation and anthropogenic climate change. Preventing potentially invasive alien plant species from becoming introduced is the most cost‐effective way to protect Norway's ecosystems from future
Katy Ivison   +6 more
wiley   +1 more source

A novel SYNJ1 homozygous variant causing developmental and epileptic encephalopathy in an Afro‐Caribbean individual

open access: yesMolecular Genetics &Genomic Medicine, Volume 11, Issue 1, January 2023., 2023
We present an individual with developmental and epileptic encephalopathy due to homozygosity for a novel SYNJ1 pathogenic c.242‐2A>G variant. The SYNJ1 protein functions to regulate synaptic vesicle recycling in neurons. Very few papers describing SYNJ1 variants are in the medical literature.
Mary Maj   +10 more
wiley   +1 more source

Grassroots Initiatives as Political Actors: Scaling, Capture and Constituency in Food Policy Councils

open access: yesEnvironmental Policy and Governance, EarlyView.
ABSTRACT Grassroots initiatives (GIs) play a crucial role in driving sustainability transitions. They adopt different approaches to exert impact through multi‐stakeholder governance platforms, such as ‘scaling up’, ‘scaling through’ and ‘amplifying’.
Francesca Fiore   +2 more
wiley   +1 more source

Consensus Virtual Screening Protocol Towards the Identification of Small Molecules Interacting with the Colchicine Binding Site of the Tubulin‐microtubule System

open access: yesMolecular Informatics, Volume 42, Issue 1, January 2023., 2023
Abstract Modification of the tubulin‐microtubule (Tub‐Mts) system has generated effective strategies for developing different treatments for cancer. A huge amount of clinical data about inhibitors of the tubulin‐microtubule system have supported and validated the studies on this pharmacological target.
Edgar López‐López   +2 more
wiley   +1 more source

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