Results 241 to 250 of about 288,401 (329)

Imitation of location choices for rare foreign ventures: Tax‐motivated relocations of headquarters

open access: yesGlobal Strategy Journal, EarlyView.
Abstract Research Summary Peer firms tend to imitate each other's location choices for foreign subsidiaries. We examine whether they also engage in location choice imitation when undertaking rare, high‐stakes foreign ventures in the form of tax‐motivated relocations of headquarters.
Aleksi Eerola   +2 more
wiley   +1 more source

Spirocyclic Diamine Scaffolds for Medicinal Chemistry

open access: yesHelvetica Chimica Acta, EarlyView.
Here we enumerated 391 spirocyclic diamine drug scaffolds with ring sizes four to eight and found that most of them are unknown. We prepared four novel such spirocycles and discovered a micromolar inhibitor of the M4 muscarinic receptor. ABSTRACT Medicinal chemistry requires the exploration of structurally diverse compound families to expand the ...
Aline Carrel   +3 more
wiley   +1 more source

Service Work as Lived Experience: A Problematizing Review

open access: yesHuman Resource Management, EarlyView.
ABSTRACT Between employee burnout and growing recruitment challenges, a systemic crisis confronts the service industry. One reason lies in the scope of received human resource management (HRM) approaches, which often emphasize organizational performance metrics at the expense of the emotional, social, and material experiences of doing frontline service
Kushagra Bhatnagar   +2 more
wiley   +1 more source

Delivering precision oncology in metastatic breast cancer: Clinical impact of comprehensive genomic profiling—The CATCH experience

open access: yesInternational Journal of Cancer, EarlyView.
What's New? CATCH is a prospective precision oncology registry trial that harnesses whole‐genome/exome‐ and RNA‐sequencing to enable actionable biomarker detection in metastatic breast cancer patients of any subtype. The data of the first 412 consecutive patients with completed follow‐up in this real‐world, single‐center patient cohort provide robust ...
Mario Hlevnjak   +31 more
wiley   +1 more source

TargetGen‐RNN model discovers novel antibiotic compound targeting drug‐resistant Staphylococcus aureus

open access: yesInterdisciplinary Medicine, EarlyView.
TargetGen‐recurrent neural network (RNN), an advanced generative model, generated 28,708 unique and novel compounds, identifying SAK‐2970 as a potent antibiotic against drug‐resistant Staphylococcus aureus. Exhibiting strong biofilm inhibition, high therapeutic efficacy, and minimal systemic toxicity in vivo, SAK‐2970 highlights its safety and clinical
Shakeel Ahmad Khan   +2 more
wiley   +1 more source

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