Results 251 to 260 of about 289,315 (327)

TargetGen‐RNN model discovers novel antibiotic compound targeting drug‐resistant Staphylococcus aureus

open access: yesInterdisciplinary Medicine, EarlyView.
TargetGen‐recurrent neural network (RNN), an advanced generative model, generated 28,708 unique and novel compounds, identifying SAK‐2970 as a potent antibiotic against drug‐resistant Staphylococcus aureus. Exhibiting strong biofilm inhibition, high therapeutic efficacy, and minimal systemic toxicity in vivo, SAK‐2970 highlights its safety and clinical
Shakeel Ahmad Khan   +2 more
wiley   +1 more source

Understanding Autistic Young Adults' Perceptions and Experiences of Traumatic and Stressful Events

open access: yesJournal of Clinical Psychology, Volume 81, Issue 6, Page 445-461, June 2025.
ABSTRACT Objectives The aim of this study was to explore how young autistic adults experience and respond to stressful life events, and the relationship between autistic characteristics and symptoms of stress associated with these events. Methods Using an exploratory sequential mixed‐methods approach, an online qualitative survey was first administered
Alliyza Lim, Robyn L. Young
wiley   +1 more source

Deliberate Practice Supervision to Enhance the Effectiveness of Behavioral Activation for Depression: A Case Study

open access: yesJournal of Clinical Psychology, Volume 81, Issue 6, Page 526-537, June 2025.
ABSTRACT Deliberate Practice (DP) is a model of behavioral skill acquisition structured by several key tasks. The past decade has shown a consistent growth in interest in this form of learning for psychotherapy skills, with promising research suggesting DP training is superior to traditional learning methods of psychotherapy. This paper presents a case
Dan Sacks
wiley   +1 more source

Application of Psychometric Methods in Dimensional Analysis and Integration of Assessment Tools in Early Diagnosis for Autism Spectrum Disorder

open access: yesJournal of Clinical Psychology, EarlyView.
ABSTRACT Background Early diagnosis of autism spectrum disorder (ASD) is crucial for timely intervention, and requires reliable and valid screening and diagnostic tools. The Toddler Module of the Autism Diagnostic Observation Schedule, Second Edition (ADOS‐2), is widely used but its factor structure and applicability in the clinical practice need ...
Ilenia Le Donne   +6 more
wiley   +1 more source

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