Results 311 to 320 of about 315,016 (384)

Design, Synthesis, and In Silico Insights of new 4‐Piperazinylquinolines as Antiproliferative Agents against NCI Renal Cancer Cell Lines

ChemistryOpen, EarlyView.
A novel series of hybrid 4‐(4‐benzoylpiperazin‐1‐yl)‐6‐nitroquinoline‐3‐carbonitrile derivatives has been designed, synthetized and evaluated for anticancer properties on the NCI60 panel. Strong antiproliferative effects have been detected against renal cancer cells.
Gabriele La Monica, Alessia Bono, Federica Alamia, Annamaria Martorana, Antonino Lauria   +4 more
wiley   +1 more source

The Impact of Vitamin D Supplementation Duration on Early Childhood Developmental Milestones: A Retrospective Study. [PDF]

Nutrients
Praticò AD, Lo Bianco M, Leonardi R, Polizzi A, Ruggieri M.   +4 more
europepmc   +1 more source

Development of an Integrated Computational Pipeline for PARP‐1 Inhibitor Screening Using Hybrid Virtual Screening and Molecular Dynamics Simulations

ChemistryOpen, EarlyView.
Poly(ADP‐ribose) polymerase 1 (PARP‐1) is vital for DNA repair. A computational workflow integrating AI‐driven virtual screening (TransFoxMol, KarmaDock, AutoDock Vina) and molecular dynamics identified novel PARP‐1 inhibitors with promising efficacy and minimized side effects.
Guan Wang, Jingjing Guo, Feng Xu, Mingjuan Ji   +3 more
wiley   +1 more source

Do Policy Capacities Matter for Federal Policy Design? Evidence From the Implementation of Three Social Policies in Brazil

Public Administration and Development, EarlyView.
ABSTRACT Bringing together the literature on policy design, policy capacity and policy making in multilevel systems, this paper argues that the effectiveness of policy design in federal countries depends, ceteris paribus, on the adequacy of federal and local policy capacities.
Giliberto Capano, Vanessa Elias de Oliveira   +1 more
wiley   +1 more source

Digital detection of Alzheimer's disease using smiles and conversations with a chatbot. [PDF]

Sci Rep
Takeshige-Amano H, Oyama G, Ogawa M, Fusegi K, Kambe T, Shiina K, Ueno SI, Okuzumi A, Hatano T, Motoi Y, Kawakami I, Ando M, Nakayama S, Ishida Y, Maei S, Lu X, Kobayashi T, Wooden R, Ota S, Morito K, Ito Y, Nakajima Y, Yoritaka A, Kato T, Hattori N.   +24 more
europepmc   +1 more source

Moderation Effect of Emotional Expressivity on the Associations Between Schizotypal Traits, Autistic Traits and Social Pleasure

PsyCh Journal, EarlyView.
ABSTRACT Diminished social pleasure has been reported in people with schizophrenia and autism spectrum disorder (ASD). Previous studies suggested that emotional expressivity is closely correlated with social pleasure. However, the underlying psychological mechanisms between traits related to schizophrenia and ASD, emotional expressivity, and social ...
Li‐Ying Zhang, Miao Wang, Xin‐Wei Fu, Shou‐Nuo Chen, Jie Gu, Shuai‐Biao Li, Min‐Yi Chu, Yan‐Yu Wang, Yi Wang, Raymond C. K. Chan   +9 more
wiley   +1 more source

Effect of creatine monohydrate on motor function in children with facioscapulohumeral muscular dystrophy: A multicenter, randomized, double‐blind placebo‐controlled crossover trial

Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, EarlyView.
Abstract Background Facioscapulohumeral muscular dystrophy (FSHD) is a rare, progressive muscle disease with no available disease‐modifying therapy. Creatine monohydrate (CrM) has been shown to improve muscle strength in individuals with muscular dystrophies but has not been tested in young people with FSHD.
Ian R. Woodcock, Katy de Valle, Anita Cairns, Zoe E. Davidson, Michael Kean, Nisha Varma, Anneke Grobler, David Metz, Kate Carroll, Nuran Dilek, Chad Heatwole, Monique M. Ryan, Martin B. Delatycki, Eppie M. Yiu   +13 more
wiley   +1 more source

Big Girl Words. [PDF]

US Cardiol
Goodman R.
europepmc   +1 more source

A Conceptual Framework for Whole‐School Implementation of Mindfulness Programs and Practices: Wisdom From the Field

Psychology in the Schools, EarlyView.
ABSTRACT Despite the growing prevalence of mindfulness in schools, the empirical landscape describing best practices for implementation is incomplete. The purpose of this project was to develop a framework that explicated the steps and considerations for implementing mindfulness at the whole‐school level, rather than just considering individual ...
Sebrina L. Doyle Fosco, Deborah L. Schussler, Melia A. Brown, Julia Mahfouz, Nava Levit‐Binnun, Todd Cantrell, Sabre Cherkowski, Tyralynn Frazier, Patricia A. Jennings, Karen Krisch   +9 more
wiley   +1 more source

Impact of dental caries and Self-perceived oral health on daily lives of children and mothers in rural Egypt: a household survey. [PDF]

BMC Oral Health
Aly NM, Ihab M, Ammar N, Quritum M, Moussa H, El Tantawi M.   +5 more
europepmc   +1 more source