Results 71 to 80 of about 56,397 (288)

Facing exclusion and smiling through the pain: positive emotion expression during interpersonal ostracism

, 2019
Elena Svetieva,1 Lisa Zadro,2 Daejoong Kim,3 Carolyn M Hurley,4 Rani Goodacre21Department of Communication, University of Colorado, Colorado Springs, CO, USA; 2School of Psychology, University of Sydney, Sydney, NSW, Australia; 3Department of Media &
Kim D, Svetieva E, Zadro L, Hurley CM, Goodacre R   +4 more
core  

Senkyunolide I Inhibits mtDNA‐cGAS‐STING Signaling in Macrophages via Targeting VDAC1 Oligomerization to Attenuate Ulcerative Colitis

Advanced Science, EarlyView.
In macrophages, senkyunolide I (SEI) directly targets the K12 residue of VDAC1 to inhibit its stress‐induced oligomerization, a critical upstream event that effectively prevents mitochondrial DNA release and subsequent cGAS‐STING pathway activation.
Zhiming Ye, Yihang Huang, Bohao Han, Lei Zhang, Can Yu, Yang Yang, Bing Liu, Yongping Jian, Zhixiang Xu, Cheng Zeng   +9 more
wiley   +1 more source

Training Approach-Avoidance of Smiling Faces Affects Emotional Vulnerability in Socially Anxious Individuals

Frontiers in Human Neuroscience, 2013
Previous research revealed an automatic behavioral bias in high socially anxious individuals (HSAs): Although their explicit evaluations of smiling faces are positive, they show automatic avoidance of these faces. This is reflected by faster pushing than
Mike eRinck, Sibel eTelli, Isabel eKampmann, Marcella L. Woud, Merel eKerstholt, Sarai ete Velthuis, Matthias eWittkowski, Eni S Becker   +7 more
doaj   +1 more source

A Site‐Aware Representation Learning Framework For Unified Molecular Interaction Modeling and Generative Design

Advanced Science, EarlyView.
MolDBG is a site‐aware, sequence‐only framework that unifies drug‐target affinity prediction, binding‐site identification, and affinity‐conditioned molecular generation for structured proteins. Guided by multi‐task binding‐site supervision, it aligns interaction‐critical residues before learning drug‐target representations and simultaneously infers ...
Gang Luo, Qianqian Zhang, Chenhao Wang, Zhiheng Yi, Alex Jinpeng Wang, Jing Tang, Min Li   +6 more
wiley   +1 more source

The smile.

South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1971
SAMJ 45(6): 154 ...
openaire   +3 more sources

Smiling girl with braids

, 1945
A young girl is shown with three braids held at the ends by clothespins. She also wears a fabric bow at the top of one braid.
Fox, O. James
core  

Uncoupling Type I Interferon Benefits From Inflammatory Toxicity: Transformer‐Prioritized Precision Agonists for Potent and Safer Cancer Immunotherapy

Advanced Science, EarlyView.
A Transformer‐based AI framework, DLINP, screens millions of compounds to identify Co68, a cobalt‐pincer organometallic complex that biases TLR4‐MD2 signaling toward antitumor interferon activation while suppressing inflammatory toxicity through an early TLR4‐SYK‐STAT1 axis.
Xuefei Guo, Yang Zhao, Xianle Rong, Xingyu Chen, Xiao Wang, Tianyi Liu, Yunfei Xie, Yushu Zou, Pingsen Zhao, Qiang Liu, Fuping You   +10 more
wiley   +1 more source

Targeting β2‐Adrenergic Receptor Stability With Lycorine Reveals a Host‐Directed Pathway for Antiviral Defense Against Poxviruses

Advanced Science, EarlyView.
Chronic stress drives autophagy‐mediated β2‐AR degradation, impairing antiviral immunity and promoting poxvirus lethality. Lycorine directly stabilizes β2‐AR to restore host defense, suppress excessive inflammation and improve survival. ABSTRACT Psychological stress is a pervasive yet poorly understood modulator of infectious disease outcomes. Here, we
Xin Zhang, Shuqin Xu, Zixuan Zhang, Chenwen Wan, Xiaoqin Wang, Peihua Wang, Huini Yang, Tianxiao Huang, Yijia Yuan, Faiza Atique, Rui Yang, Yingli He, Zhijun Liu   +12 more
wiley   +1 more source

Difference in clinical crown length of maxillary central incisors and gingival display at rest and during smiling based on gender

Padjadjaran Journal of Dentistry, 2013
Introduction: The aim of the present study was to investigate the effect of gender on the degree of maxillary central incisors and associated gingival display when the lips are at rest and during smiling. Methods: A total of 65 subjects (40 females [61.5%
Nadia Atina Zaini, Rasmi Rikmasari, Lisda Damayanti   +2 more
doaj   +1 more source

A Unified Hierarchical Multiscale Fusion Framework for Drug–Target Affinity Prediction: From Benchmark Performance to Nanomolar Inhibitor Discovery

Advanced Science, EarlyView.
A multimodal fusion framework integrating sequence, atomic, and fragment representations captures drug–target interactions across multiple scales. The model delivers strong predictive performance and enables efficient virtual screening. Applied to hematopoietic progenitor kinase 1 (HPK1), it identifies structurally diverse inhibitors with nanomolar ...
Shuo Liu, Xiang Zhang, Haixia Feng, Yuquan Li, Xiaoqing Gong, Yong Liang, Xiaojun Yao, Huanxiang Liu   +7 more
wiley   +1 more source