Results 271 to 280 of about 1,270,906 (355)

Histopathological Study of Changes in White-Pulp Structure Due to Lymphoid Depletion in the Spleen in Male Rats Caused by Exposure to Transitional Cigarette Smoke. [PDF]

Toxics
Hartady T, Sifora S, Lesmana R, Sarniem BC.   +3 more
europepmc   +1 more source

Single‐Cell Transcriptomics Reveals FLS2‐Dependent Hypoxia Signaling and ERF13‐Mediated Transcription During flg22‐Triggered Immunity

Advanced Science, EarlyView.
This study employs sc‐RNA sequencing, genetics, and phenotyping to systematically map the cell‐type‐specific immune responses triggered by flg22. It reveals FLS2‐dependent transcriptional reprogramming in epidermal and mesophyll cells, and uncovers crosstalk between immune and hypoxia signaling pathways.
Yaping Zhou, Aizhi Qin, Mengfan Li, Qianli Zhao, Luyao Kong, Lulu Yan, Chunyang Li, Hao Liu, Yinpeng Zhang, Jiani Long, Mengyu Liao, Mengmeng Zhou, Xiaoli Fan, Baozhen Wang, Wenxuan Kang, Shui Wang, Zhixin Liu, Xuwu Sun   +17 more
wiley   +1 more source

Changes in the prevalence of adolescent tobacco use and its associated factors in Indonesia: analysis of repeated cross-sectional survey 2009-2019. [PDF]

BMJ Open
Suryadarma AY, Saputro SA, Isnuwardana R, Destiwi M, Bassey PE, Martini S, Sebayang SK.   +6 more
europepmc   +1 more source

DMAP1 Deficiency Suppresses Lung Cancer Progression by Destabilizing Replication Fork and Activating IFN Signaling‐Mediated Anti‐tumor Immunity

Advanced Science, EarlyView.
Lung cancer remains the leading cause of cancer‐related death. We investigated the role of the epigenetic regulator DMAP1 in NSCLC and found that its loss induces replication stress and DNA damage. This in turn activates type I IFN signaling via the cGAS–STING pathway and transcriptional ISG de‐repression, enhancing anti‐tumor immune responses ...
Kan Huang, Xi Dai, Shuaihu Li, Yingxue Chen, Yaxin Yu, Lin Wang, Kun Liu, Shuhan Lyu, Chongyang Li, Yihua Sun, Fei Li   +10 more
wiley   +1 more source

Longitudinal multi-omics evidence reveals lung injury and concurrent disruption of intestinal flora and serum metabolism by cigarette smoke and influenza virus. [PDF]

Front Cell Infect Microbiol
Liu Z, Li H, Xiang Y, Ren S, Pan W, Ling Z, Dong J, Liang Z, Quan J, Fan L, Lin L, Wu L, Yu X.   +12 more
europepmc   +1 more source

Multicohort Validation of Gut Microbiome Signatures for Cholangiocarcinoma Diagnosis and Functional Characterization of Bifidobacterium Pseudocatenulatum

Advanced Science, EarlyView.
This study analyzes gut bacteria in cholangiocarcinoma patients, revealing distinct microbial signatures that enable accurate disease detection. Species‐based diagnostic models achieved over 98% accuracy in identifying cholangiocarcinoma and distinguished it from other liver diseases. The research demonstrates that specific beneficial bacteria suppress
Benchen Rao, Jianwen Jiang, Ruiqing Zhang, Dongya Zhang, Chenchen Zhang, Ang Li, Haifeng Lu, Hua Zhang, Lin Zhou, Wenzhi Guo, Peihao Wen, Jianfeng Xue, Jie Pan, Tuerganaili Aji, Zhou Lan, Xianzhi Jiang, Shusen Zheng, Zujiang Yu, Zhigang Ren   +18 more
wiley   +1 more source

Pathogens on fire: a scoping review of smoke-borne pathogen ecology in the One Health framework. [PDF]

PeerJ
Adhikari A, Kraisitudomsook N, Bonfantine KL, Lampman P, Fox S, Smith JA, Mehrad B, Kobziar LN, Garrett KA.   +8 more
europepmc   +1 more source

KCNJ2 is Required for NLRP3 Inflammasome Activation That Drives Allergic Airway Inflammation and Remodeling

Advanced Science, EarlyView.
This study aims to evaluate the impact of the potassium channel KCNJ2 on asthma development. KCNJ2 promotes NLRP3 inflammasome activation through both Ca2+ influx and K+ efflux in airway epithelial cells, which drives allergic airway inflammation and remodeling, suggesting a promising therapeutic target for asthma.
Yachao Cui, Shumei Wu, Yang Peng, Yiqi Liu, Li Che, Shiying Chen, Feng Zhang, Dajiang Qin, Shiyue Li, Pixin Ran, Wenguang Yin   +10 more
wiley   +1 more source

Alterations to the bronchial gene-expression effects of tobacco smoking in people living with HIV. [PDF]

J Acquir Immune Defic Syndr
Lee M, Olson A, Pickering RT, Ieong MH, Kivett D, Roche S, Xiao X, Liu G, Asundi A, Lin NH, Lenburg ME.   +10 more
europepmc   +1 more source