Results 171 to 180 of about 69,662 (295)

Allergic Sensitization to Inhalant Allergens in the Upper Respiratory Tract—the B Cell Side

Allergy, EarlyView.
ABSTRACT Allergic diseases are on the rise worldwide, driven by respiratory epithelial barrier dysfunction that promotes sensitization to inhalant allergens such as pollen, dust mites, pet dander, and fungal spores. These antigens trigger IgE‐mediated immune responses that lead to diseases such as allergic rhinitis (AR) and asthma.
Ola Grimsholm, Mohammed Zghaebi, Bita Hambrecht, Tanja Kalic, Christopher C. Udoye, Rudolf Manz, Barbara Bohle, Katarzyna M. Sitnik, Julia Eckl‐Dorna, Heimo Breiteneder   +9 more
wiley   +1 more source

Update on Non‐Biological and RNA‐Based Therapeutics in Chronic Inflammatory Diseases: Precision Medicine Through Small Molecules: An EAACI Position Paper

Allergy, EarlyView.
ABSTRACT In the last decades, critical advancements in research technology and knowledge on disease mechanisms steered therapeutic approaches for chronic inflammatory diseases towards unprecedented target specificity. For allergic and chronic lung diseases, biologic drugs pioneered this goal, acquiring on the way—through the clinical use of monoclonal ...
F. Roth‐Walter, I. M. Adcock, C. Benito‐Villalvilla, R. Bianchini, L. Bjermer, G. Caramori, L. Cari, K. F. Chung, Z. Diamant, I. Eguiluz‐Gracia, E. F. Knol, M. Jesenak, F. Levi‐Schaffer, G. Nocentini, L. O'Mahony, O. Palomares, F. Redegeld, M. Sokolowska, B. Van Esch, M. Zurlo, C. Stellato   +20 more
wiley   +1 more source

Bone marrow mesenchymal stem cells alleviate smoke inhalation injury by regulating alveolar macrophage polarization via the CD200-CD200R pathway. [PDF]

Front Immunol
Ding Z, Zhuang Y, Zhao Y, Shi J, Guo X, Fan H, Lv Q.   +6 more
europepmc   +1 more source

Small Airways Dysfunction and Remission in Adults With Asthma: A Longitudinal Exploratory Analysis of the AssessmenT of smalL Airways involvemeNT In aSthma (ATLANTIS) Study

Allergy, EarlyView.
We conducted a post hoc analysis of ATLANTIS, a multinational prospective study including 684 adults with asthma. Fewer small airway symptoms and lower disease activity are independently associated with asthma remission. Replicated airway transcriptomic signatures show increased IL‐4/13 signalling and reduced coagulation pathways across the ATLANTIS ...
Akshi Kumar, Rory Chan, Nazanin Zounemat‐Kermani, Eleanor Quek, Ian M. Adcock, Bianca Beghe, Christopher Brightling, Dave Singh, Janwillem Kocks, Alberto Papi, Klaus F. Rabe, Ulrica Scaffidi‐Argentina, Maarten van den Berge, Monica Kraft, Salman Siddiqui   +14 more
wiley   +1 more source

Ion transport mechanisms for smoke inhalation-injured airway epithelial barrier. [PDF]

Cell Biol Toxicol, 2020
Chang J, Chen Z, Zhao R, Nie HG, Ji HL.
europepmc   +1 more source

Nasal Airway Transcriptome Reflects Selected Asthma‐Associated Gene Signatures in the Lower Airways

Allergy, EarlyView.
Seven genes and two gene modules were consistently associated with asthma in both airway compartments in ARMS and were validated in ATLANTIS. The two modules reflected IL‐13 related inflammation and mast cell activity, respectively. Nasal gene signatures provide a non‐invasive proxy for selected bronchial asthma‐associated gene signatures. ARMS, Asthma
Hui Wen, Tessa Kole, Orestes A. Carpaij, Tatiana Karp, Victor Guryev, Alen Faiz, Kian Fan Chung, Pankaj Bhavsar, Ian M. Adcock, Salman Siddiqui, Andy Lan, Katie L. Raby, Nazanin Zounemat‐Kermani, Chris Brightling, Dave Singh, Janwillem Kocks, Monica Kraft, Bianca Beghé, Klaus F. Rabe, Alberto Papi, Machteld N. Hylkema, Martijn C. Nawijn, Maarten van den Berge   +22 more
wiley   +1 more source

Obstructive Tracheal Necrosis in a Dog Secondary to Smoke Inhalation Injury-Case Report. [PDF]

Front Vet Sci, 2020
Rosati T, Burkitt JM, Watson KD, Jandrey KE, Osborne LG, Sinnott DM, Epstein SE.   +6 more
europepmc   +1 more source

Pirfenidone alleviates smoke inhalation lung injury of rats via the NF-κB signaling pathway. [PDF]

Immun Inflamm Dis
Lv T, Yang K, Wang J.
europepmc   +1 more source

Peat smoke inhalation alters blood pressure, baroreflex sensitivity, and cardiac arrhythmia risk in rats. [PDF]

J Toxicol Environ Health A, 2020
Martin BL, Thompson LC, Kim YH, King C, Snow S, Schladweiler M, Haykal-Coates N, George I, Gilmour MI, Kodavanti UP, Hazari MS, Farraj AK.   +11 more
europepmc   +1 more source

Immunological features of chronic obstructive pulmonary disease (COPD) induced by indoor pollution and cigarette smoke [PDF]

, 2012
Adcock, IM, Barnes, PJ, Heidarnazhad, H, Masjedi, MR, Mortaz, E   +4 more
core   +1 more source