Results 41 to 50 of about 105,905 (343)

Small-Scale Experimental Study on Smoke Blocking and Thermal Insulation Performance of Water Mist Sprinkler

Fire
To investigate the performance patterns of high-pressure water mist sprinklers with different flow coefficients in smoke containment and thermal insulation during fire suppression, this study conducted droplet size experiments and small-scale fire tests ...
Jianan Men, Qiang Liang, Hui Xu, Zhenyu Liu, Jielong Lv, Xiaopo Wang   +5 more
doaj   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Simulation study on optimization of smoke control and exhaust strategies for networked underground tunnel groups

Meitan xuebao
Smoke control in the complex structure of network-type giant underground tunnels is a difficult problem. Due to the multiple and random fire causes, high temperature of smoke gathering at the top of the enclosed space, multipath rapid propagation, and ...
Ruinan AN, Peng LIN, Yong XIA, Xin Wang, Weifeng ZHANG, Chao ZHANG, Shuai ZHANG   +6 more
doaj   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Changes in Immune‐Inflammation Status and Acute Ischemic Stroke Prognosis in Prospective Cohort

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Inflammation is a critical risk factor for poor outcomes in cerebral infarction. Prior studies focused primarily on baseline inflammation status, neglecting dynamic longitudinal changes. We try to investigate the association between immune‐inflammation status alterations and stroke prognosis, and evaluated three systemic biomarkers'
Songfang Chen, Wenting Huang, Yitian Liu, Xuan Chen, Buyu Ke, Qian Shen, Hanyu Cai, Jing Sun, Yan Li, Yungang Cao, Beilei Hu, Keyang Chen   +11 more
wiley   +1 more source

Characteristics and microscopic mechanisms of smoke emissions of OMMT/SBS-modified asphalt

Environment International
Nanomaterials are increasingly being used in road engineering with the development of road construction technology. The smoke suppression performance of asphalt can be substantially improved using organic nano-montmorillonite (OMMT)/styrene–butadiene ...
Wanhong Yang, Zhenghao Zhang, Xiaolong Yang, Xiaofan Jia, Yixin Jiang   +4 more
doaj   +1 more source

Effects of Size of Zinc Borate on the Flame Retardant Properties of Intumescent Coatings

International Journal of Polymer Science, 2019
This paper is aimed at assessing the fire retardancy and thermal stability of intumescent flame retardant (IFR) containing ammonium polyphosphate (APP), pentaerythritol (PER), and melamine (MEL). Zinc borate (ZB) was added at the loading of 2%, 4%, 6%, 8%
Ning Lu, Pengchao Zhang, Ya’nan Wu, Danqing Zhu, Zhu Pan   +4 more
doaj   +1 more source

The antisaccade task as an index of sustained goal activation in working memory: modulation by nicotine [PDF]

, 2006
The antisaccade task provides a laboratory analogue of situations in which execution of the correct behavioural response requires the suppression of a more prepotent or habitual response.
A Nordberg, AL Larrison, AL Larrison-Faucher, B Fischer, B Reuter, C Massen, C Pierrot-Deseilligny, C Vidal, CM Martin-Ruiz, CS Myers, D Paterson, DM Warburton, DP Munoz, DV Poltavski, E Stuyven, EA Witte, ED Levin, ED Levin, ED Levin, G Mancuso, HM Arnold, J Foulds, J Leon de, J Powell, Jennifer M. Rusted, JG Harris, JH Bettany, JJ Buccafusco, JJ Buccafusco, JM Findlay, JP Mitchell, KA Perkins, KO Fagerström, L Depatie, M Ernst, M Reuben, ME Calkins, N Rycroft, N Unsworth, Nicola Rycroft, PBS Clarke, PE Hallett, R Dar, R Godijn, RJ Leigh, RJ Roberts, RJ West, RM Eenshuistra, S Leonard, S Nieuwenhuis, SA Khan, Samuel B. Hutton, SB Hutton, SB Hutton, SB Hutton, T Bates, T Edginton, U Ettinger, U Ettinger, V Casa Della, V Kumari, V Kumari, WA Corrigall, WS Griesar, YBWEM Roos   +64 more
core   +1 more source

Sarilumab in Polyarticular‐Course Juvenile Idiopathic Arthritis: Dose‐Finding and One‐Year Analysis of a Phase 2b, Open‐Label, Multicenter Study

Arthritis Care &Research, Accepted Article.
Objective This study assessed sarilumab in treating patients with polyarticular‐course juvenile idiopathic arthritis (pcJIA). Methods This phase 2b, open‐label study (NCT02776735) consisted of three sequential parts (each with a core‐treatment and extension‐phase). During part 1, three doses were assessed in two weight groups (Group A/B: ≥30–60 kg/≥10–<
Fabrizio De Benedetti, Inmaculada C. Penadés, Irina Nikishina, Ivan Foeldvari, Alberto J. Spindler, Anna Kozlova, Nadina Rubio‐Pérez, Pierre Quartier, Zbigniew Żuber, Raul Barria, Daniel Clemente, Gabriel V. Cornejo, Katherine Marzan, Nancy Liu, Christine Xu, Stephen DiMartino, Angeliki Giannelou, Fei Cao‐Ghoul, Bolanle Akinlade, Lydie Baret‐Cormel   +19 more
wiley   +1 more source