Results 41 to 50 of about 602,024 (301)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Incidence of fires and related injuries after giving out free smoke alarms: cluster randomised controlled trial [PDF]

, 2002
Objective To measure the effect of giving out free smoke alarms on rates of fires and rates of fire related injury in a deprived multiethnic urban population. Design Cluster randomised controlled trial.
Edwards, P., Pan, HQ, Wade, Angie, Sculpher, M, Sculpher, Mark, Wade, A., Slater, S, Edwards, P, Pan, H., Roberts, I., Roberts, Ian, Slater, Suzanne, Slater, S., Diguiseppi, C., Godward, C., DiGuiseppi, Carolyn, Wade, A, Godward, Catherine, Edwards, Phil, Godward, C, Sculpher, M., DiGuiseppi, C, Roberts, I, Pan, Huiqi   +23 more
core   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Simulation study on optimization of smoke control and exhaust strategies for networked underground tunnel groups

Meitan xuebao
Smoke control in the complex structure of network-type giant underground tunnels is a difficult problem. Due to the multiple and random fire causes, high temperature of smoke gathering at the top of the enclosed space, multipath rapid propagation, and ...
Ruinan AN, Peng LIN, Yong XIA, Xin Wang, Weifeng ZHANG, Chao ZHANG, Shuai ZHANG   +6 more
doaj   +1 more source

Hydrothermal Synthesis of Lanthanum-Doped MgAl-Layered Double Hydroxide/Graphene Oxide Hybrid and Its Application as Flame Retardant for Thermoplastic Polyurethane

Advances in Polymer Technology, 2020
A novel lanthanum-doped MgAl-layered double hydroxide/graphene oxide hybrid (La LDH/GO) with a La3+/Al3+ molar ratio of 0.05 was successfully synthesized by the hydrothermal method.
Yi Qian, Peng Qiao, Long Li, Haoyue Han, Haiming Zhang, Guozhang Chang   +5 more
doaj   +1 more source

Engineering amine-modified ammonium polyphosphate for enhancing flame retardancy and smoke suppression of vinyl ester resin [PDF]

Vinyl ester resin (VER), as a common thermosetting resin, has been widely used in many engineering fields. However, VER suffers from intrinsic flammability, and it can’t meet the increasingly stringent fire safety requirements.
Hou, Boyou, Yang, Qingshan, Mushtaq, Asim, Chu, Tao, Zeng, Xuesen, Jafari, Pooya, Song, Pingan, Lu, Yixia, Zhou, Zhezhe, Guo, Yong, Huo, Siqi   +10 more
core   +1 more source

Histone deacetylase 2 is phosphorylated, ubiquitinated, and degraded by cigarette smoke [PDF]

, 2009
Cigarette smoke (CS)-induced lung inflammation involves the reduction of histone deacetylase 2 (HDAC2) abundance, which is associated with steroid resistance in patients with chronic obstructive pulmonary disease and in individuals with severe asthma who
Adenuga, David, Yao, Hongwei, Rahman, Irfan, Seagrave, JeanClare, March, Thomas H   +4 more
core   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

LMDFS: A Lightweight Model for Detecting Forest Fire Smoke in UAV Images Based on YOLOv7

Remote Sensing, 2023
Forest fires pose significant hazards to ecological environments and economic society. The detection of forest fire smoke can provide crucial information for the suppression of early fires.
Gong Chen, Renxi Cheng, Xufeng Lin, Wanguo Jiao, Di Bai, Haifeng Lin   +5 more
doaj   +1 more source

Impact of Scottish smoke-free legislation on smoking quit attempts and prevalence [PDF]

, 2011
<p><b>Objectives:</b> In Scotland, legislation was implemented in March 2006 prohibiting smoking in all wholly or partially enclosed public spaces. We investigated the impact on attempts to quit smoking and smoking prevalence.</p>
Daniel F. Mackay, Mackay Daniel F., Haw, S., Pell, J.P., Pell, Jill, Mackay, D.F., Jill P Pell, Daniel F Mackay, Sally Haw, Pell Jill P., Mackay, Daniel F, Haw, Sally, Jill P. Pell, Haw Sally   +13 more
core   +1 more source