Results 201 to 210 of about 2,195,916 (338)

Smoking as a Risk Factor for Cardiovascular Disease in Females and Males: Observational and Mendelian Randomisation Analyses in the UK Biobank. [PDF]

open access: yesGlob Heart
de Ruiter SC   +8 more
europepmc   +1 more source

Type 2 Diabetes‐Associated Phenylacetylglutamine Induces Deleterious Inflammation Cycle in Myeloid Cells through β2 Adrenergic Receptors and Impedes Wound Healing

open access: yesAdvanced Science, EarlyView.
The microbiota‐derived metabolite phenylacetylglutamine (PAGln) is elevated in type 2 diabetes and tightly associated with poor healing in both diabetic and non‐diabetic human patients. PAGln promotes mouse inflammation and impairs healing through a transmissible β2‐adrenergic receptor–mediated trained‐immunity loop.
Lu Huang   +12 more
wiley   +1 more source

Relationship Between Smoking and Psychiatric and Somatic Comorbidities in Older Age Bipolar Disorder: Lien entre le tabagisme et les affections psychiatriques et somatiques concomitantes chez les personnes âgées atteintes de trouble bipolaire. [PDF]

open access: yesCan J Psychiatry
Howland M   +21 more
europepmc   +1 more source

Smohaze‐Upregulated RFWD3 Competes with TRIM24 to Stabilize TREX1 and Reduce Cytosolic dsDNA in Non‐Small Cell Lung Cancer

open access: yesAdvanced Science, EarlyView.
The E3 ubiquitin ligase RFWD3 binds the exonuclease TREX1 and protects it from TRIM24‐mediated ubiquitination and degradation, leading to the eradication of intracellular dsDNA, inhibition of the cGAS‐STING pathway, and immunosuppressive microenvironment of lung cancer.
Xue‐Yan Shi   +12 more
wiley   +1 more source

WHO FCTC: How we got here and where we are going

open access: yesTobacco Induced Diseases
Laurent Huber, Megan Arendt-Manning
doaj   +1 more source

Patterns and associated factors of cigarette smoking among medical students in 2020: a cross-sectional study from a North African country. [PDF]

open access: yesBMC Public Health
Zemni I   +13 more
europepmc   +1 more source

Enhancer Reprogramming Reveals the Tumorigenic Role of PTPRZ1 in Lung Squamous Cell Carcinoma

open access: yesAdvanced Science, EarlyView.
Lung squamous cell cancer (LUSC) is deadly due to lack of good treatments. Here, multiomics techniques are applied to LUSC tumors and find thousands of cancer‐specific enhancers controlling key genes. Interestingly, the gene PTPRZ1 is identified as a critical oncogene driven by the LUSC‐acquired enhancers. PTPRZ1 is activated by MDK, fueling cancer via
Yong‐Qiang Ning   +11 more
wiley   +1 more source

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