Results 101 to 110 of about 333,415 (291)

CK2B Induces CD8+ T‐Cell Exhaustion through HDAC8‐Mediated Epigenetic Reprogramming to Limit the Efficacy of Anti‐PD‐1 Therapy in Non‐Small‐Cell Lung Cancer

open access: yesAdvanced Science, EarlyView.
αPD‐1 therapy has left an indelible mark in the field of NSCLC treatment; however, its efficacy is limited in clinical practice owing to the effector T‐cell exhaustion. These findings underscore CK2B as a promising target for overcoming the exhaustion of effector CD8+ T cells, thereby enhancing the efficacy of αPD‐1 and adoptive cell therapies in NSCLC.
Shaochuan Liu   +15 more
wiley   +1 more source

Geschlechterperspektive als integraler Bestandteil eines Seminars zur Prävention des Tabakkonsums [Sex- and gender-related perspectives as an integral part of a seminar dealing with smoking prevention]

open access: yesGMS Zeitschrift für Medizinische Ausbildung, 2009
[english] Despite the standard of knowledge about gender-specific smoking behavior and sex-related characteristics in tobacco-attributable diseases, physicians do not feel competent in providing adequate prevention strategies against both female and male
Bisson, Susanne   +2 more
doaj   +1 more source

Video Smoke Detection Based on Deep Saliency Network [PDF]

open access: yesarXiv, 2018
Video smoke detection is a promising fire detection method especially in open or large spaces and outdoor environments. Traditional video smoke detection methods usually consist of candidate region extraction and classification, but lack powerful characterization for smoke.
arxiv  

From Invaginating Site to Deep Lesion: Spatial Transcriptomics Unravels Ectopic Endometrial Penetration Features in Adenomyosis

open access: yesAdvanced Science, EarlyView.
This work utilizes spatial transcriptomics to map the transcriptional landscape of adenomyosis with obvious invagination structure from the invaginating site to deep lesions. By integrating with single‐cell RNA sequencing, this study elucidates the molecular features of invagination, invasion, and fibrosis, and finds the major participants and vital ...
Boyu Li   +19 more
wiley   +1 more source

The Impact of Family Members and Friends Habits on Youths Smoking Behaviour: Consequences for Social Marketing [PDF]

open access: yesRevista de Management Comparat International, 2011
For implementing more effective social marketing programmes for preventing youth’s smoking more information is needed about the backgrounds of their behaviour and choices.
Anne AIDLA , Maaja VADI
doaj  

The promise of long-term effectiveness of school-based smoking prevention programs: a critical review of reviews

open access: yesTobacco Induced Diseases, 2009
I provide a review and critique of meta-analyses and systematic reviews of school-based smoking prevention programs that focus on long-term effects. Several of these reviews conclude that the effects of school-based smoking prevention programs are small ...
Brian R Flay
doaj   +1 more source

Accounting for Smoking in Forecasting Mortality and Life Expectancy [PDF]

open access: yesarXiv, 2019
Smoking is one of the main risk factors that has affected human mortality and life expectancy over the past century. Smoking accounts for a large part of the nonlinearities in the growth of life expectancy and of the geographic and sex differences in mortality.
arxiv  

The Novel Dual GIP and GLP‐1 Receptor Agonist Tirzepatide Attenuates Colon Cancer Development by Regulating Glucose Metabolism

open access: yesAdvanced Science, EarlyView.
Tirzepatide, a dual GIP/GLP‐1 receptor agonist for diabetes, suppresses colorectal cancer growth by targeting glucose metabolism. It inhibits cancer cell proliferation, promotes apoptosis, and induces tumor regression. It reduces glucose uptake and destabilizes HIF‐1α for degradation to downregulate PFKFB3/PFK‐1 enzymes, thus contributing to the ...
Yikai Zhang   +11 more
wiley   +1 more source

Exposição das crianças ao fumo ambiental do tabaco (FAT). Avaliação de uma intervenção preventiva Second hand smoke (SHS) exposure in children. An evaluation of a preventative measure

open access: yesRevista Portuguesa de Pneumologia, 2010
Objectivo: Avaliar a eficácia de uma intervenção preventiva, dirigida a alunos do 4.º ano de escolaridade e aos seus pais/encarregados de educação, com a finalidade de reduzir a exposição das crianças ao fumo ambiental do tabaco (FAT) no domicílio ...
José Precioso   +5 more
doaj  

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