Results 141 to 150 of about 2,935,561 (373)

CRISPR‐MI and scRNA‐Seq Reveal TREM2's Function in Monocyte Infiltration and Macrophage Apoptosis During Abdominal Aortic Aneurysm Development

Advanced Science, EarlyView.
A method is developed for conducting genome‐wide CRISPR/Cas9 screening of monocyte infiltration in vivo (CRISPR‐MI) that is easily adaptable across a variety of disease models. Through the combination of CRISPR‐MI and scRNA‐Seq, this study discovers that Trem2 is a key regulator of early monocyte infiltration in abdominal aortic aneurysm (AAA ...
Haocheng Lu, Chao Xue, Yang Zhao, Jinjian Sun, Changzhi Zhao, Xu Zhang, Guizhen Zhao, Yaozhong Liu, Hongyu Liu, Yongjie Deng, Ying Wang, Chi Zhang, Yingjie Liu, Linjun Zeng, Ying Yang, Bolun Li, Shusi Ding, Linkang Zhou, Henry Kuang, Zanxin Wang, Wenhao Ju, Haihuan Lin, Jie Lin, Yanhong Guo, Lin Chang, Hongmei Zhao, Jing Wang, Jiandie Lin, Lemin Zheng, Y. Eugene Chen, Jifeng Zhang   +30 more
wiley   +1 more source

NARFL Knockout Triggers Ferroptosis‐Driven Vascular Endothelial Dysfunction

Advanced Science, EarlyView.
NARFL is vital for CIA and oxidative stress resistance. NARFL deletion in HPMEC cells, zebrafish, and mice is lethal and rescued by a Ferroptosis inhibitor. NARFL deficiency disrupted its interaction with CIA proteins, decreased aconitase activity, increased IRP1 activity, induced Fe overload, and led to ferroptosis and oxidative stress, resulting in ...
Hui Hu, Jing Luo, Li Yu, Daoxi Qi, Boyu Li, Yating Chen, Chen Wang, Xiaokang Zhang, Wenzheng Guo, Qiyong Lou, Gang Zhai, Yonglin Ruan, Jianfei Huang, Shengchi Shi, Zhan Yin, Fang Zheng   +15 more
wiley   +1 more source

Contributions of a smoking prevention project in the education of medical students: qualitative research

Revista Médica de Minas Gerais
Introduction: Smoking is considered a pediatric disease, because most smokers used their first cigarette or became addicted before 18 years old.
Daiana Carolina Godoy, Gabriela Campbell Rocha, Breno Bernardes-Souza, Titus Josef Brinker, Vitor Luis Tenório Mati   +4 more
doaj   +1 more source

Author response: Smoking cessation and secondary stroke prevention [PDF]

, 2018
Amelia K. Boehme
openalex   +1 more source

Bisphenol B Exposure Induces Miscarriage by Suppressing Migration/Invasion and Migrasome Formation

Advanced Science, EarlyView.
BPB (Bisphenol B) exposure up‐regulates ER (estrogen receptor) levels, enhances its interactions with the lnc‐HZ04 promoter region, and thus promotes ER‐mediated lnc‐HZ04 transcription. Subsequently, lnc‐HZ04 suppresses TCF4 (transcription factor 4)‐mediated PKCA (protein kinase C alpha) transcription and subsequently suppresses migration/invasion and ...
Wenxin Huang, Manli Wang, Yi Sun, Xiaoping Yue, Xun Li, Yanbing Lin, Geng Guo, Depeng Zhao, Qigang Fan, Xiaoling Ma, Zhihong Zhang, Shuaishuai Xing, Xiaoting Shen, Huidong Zhang   +13 more
wiley   +1 more source

A Unique Chimeric RNA: ERCC1‐iASPP Drives Benzo[a]pyrene‐Induced Lung Carcinogenesis via Dual Coding and Non‐Coding Mechanisms

Advanced Science, EarlyView.
The chimeric RNA ERCC1‐iASPP possesses dual coding and non‐coding functions, synergistically accelerating the process of cellular malignant transformation. Abstract Genetic variation at 19q13.3 critically modulates chemical carcinogen‐induced lung carcinogenesis, particularly in mediating the activity of benzo[a]pyrene (B[a]P), a major polycyclic ...
Mingming Shan, Mingyang Xiao, Liang Zhang, Shen Wang, Jiahang Wu, Kang Cao, Yujin Li, Guopei Zhang, Junwei Xie, Xiaobo Lu   +9 more
wiley   +1 more source

Exposição das crianças ao fumo ambiental do tabaco (FAT). Avaliação de uma intervenção preventiva Second hand smoke (SHS) exposure in children. An evaluation of a preventative measure

Revista Portuguesa de Pneumologia, 2010
Objectivo: Avaliar a eficácia de uma intervenção preventiva, dirigida a alunos do 4.º ano de escolaridade e aos seus pais/encarregados de educação, com a finalidade de reduzir a exposição das crianças ao fumo ambiental do tabaco (FAT) no domicílio ...
José Precioso, Catarina Samorinha, José Manuel Calheiros, Manuel Macedo, Henedina Antunes, Hugo Campos   +5 more
doaj  

PUTTING OUT THE FIRES: WILL HIGHER TAXES REDUCE YOUTH SMOKING? [PDF]

This paper re-examines the empirical support for predictions that proposed cigarette tax or price increases will substantially reduce youth smoking. Part of the support for these predictions comes from evidence that higher taxes reduce aggregate tobacco ...
DeCicca, Philip, Kenkel, Donald, Mathios, Alan   +2 more
core  

Smohaze‐Upregulated RFWD3 Competes with TRIM24 to Stabilize TREX1 and Reduce Cytosolic dsDNA in Non‐Small Cell Lung Cancer

Advanced Science, EarlyView.
The E3 ubiquitin ligase RFWD3 binds the exonuclease TREX1 and protects it from TRIM24‐mediated ubiquitination and degradation, leading to the eradication of intracellular dsDNA, inhibition of the cGAS‐STING pathway, and immunosuppressive microenvironment of lung cancer.
Xue‐Yan Shi, Yu‐Ke Shen, Meng‐Yao Lv, Yu Sun, Yong‐Fang Lin, Zheng Wang, Xiao‐Liang Jie, Zheng Liu, Yang‐Tong Liu, Yang‐Xin Fu, Zhenhua Ren, Gui‐Zhen Wang, Guang‐Biao Zhou   +12 more
wiley   +1 more source

Identity, Acculturation, and E-Cigarette Use among Bicultural Hispanic Youth and Young Adults

Health Equity
Introduction: Research suggests Hispanic/Latino/a/x/e (hereafter Hispanic) youth/young adult (YYA) tobacco use may vary by acculturation level, but few studies have explored e-cigarette use by acculturation or how bicultural identity may affect tobacco ...
Emily C. Sanders, Sarah Evans, Alex Budenz, N. Yvette Frias, Sarah Byrnes, Everly Macario   +5 more
doaj   +1 more source