Results 71 to 80 of about 3,647,752 (207)

Mebendazole reduces vascular smooth muscle cell proliferation and neointimal formation following vascular injury in mice.

PLoS ONE, 2014
Mebendazole is an antihelminthic drug that exerts its effects via interference with microtubule function in parasites. To determine the utility of mebendazole as a potential treatment for vascular diseases involving proliferation of vascular smooth ...
Jintao Wang, Hui Wang, Chiao Guo, Wei Luo, Alyssa Lawler, Aswin Reddy, Julia Wang, Eddy B Sun, Daniel T Eitzman   +8 more
doaj   +1 more source

Na+/Ca2+ Exchanger 1 in Airway Smooth Muscle of Allergic Inflammation Mouse Model

Frontiers in Pharmacology, 2018
Cytosolic free Ca2+ ([Ca2+]cyt) is essential for airway contraction, secretion and remodeling. [Ca2+]cyt homeostasis is controlled by several critical molecules, one of which is the Na+/Ca2+ exchanger 1 (NCX1) in the plasma membrane.
Jiexia Wen, Xiangcai Meng, Bin Xuan, Tao Zhou, Heran Gao, Hui Dong, Yimin Wang, Yimin Wang   +7 more
doaj   +1 more source

Multiscale adaptive smoothing models for the hemodynamic response function in fMRI

The Annals of Applied Statistics, 2013
In the event-related functional magnetic resonance imaging (fMRI) data analysis, there is an extensive interest in accurately and robustly estimating the hemodynamic response function (HRF) and its associated statistics (e.g., the magnitude and duration of the activation).
Wang, Jiaping, Zhu, Hongtu, Fan, Jianqing, Giovanello, Kelly, Lin, Weili   +4 more
openaire   +5 more sources

Fatigue Life Prediction Using Simplified Endurance Function Model

Advances in Mechanical Engineering, 2013
A methodology is proposed to apply an endurance function model with a genetic algorithm to estimate the fatigue life of notched or smooth components. The endurance function model is based on stress tensor invariants and deviatoric stress invariants.
M. Kamal, M. M. Rahman, M. S. M. Sani
doaj   +1 more source

Smoothing and Mean–Covariance Estimation of Functional Data with a Bayesian Hierarchical Model

Bayesian Analysis, 2016
Functional data, with basic observational units being functions (e.g., curves, surfaces) varying over a continuum, are frequently encountered in various applications. While many statistical tools have been developed for functional data analysis, the issue of smoothing all functional observations simultaneously is less studied.
Yang, Jingjing, Zhu, Hongxiao, Choi, Taeryon, Cox, Dennis D.   +3 more
openaire   +5 more sources

Analytical Solutions for Charge and Flux in HP Ideal Generic Memristor Model With Joglekar and Prodromakis Window Functions

IEEE Access
This paper presents, for the first time, analytical solutions for the charge and flux as a function of the state variable in the case of the HP memristor, modeled as an ideal generic memristor with Joglekar and Prodromakis window functions for a general ...
Stanisa Dautovic, Natasa Samardzic, Anamarija Juhas, Alon Ascoli, Ronald Tetzlaff   +4 more
doaj   +1 more source

Immune algorithm for solving the smooth economic dispatch problem

Journal of Computer Science and Technology, 2015
In this paper, an algorithm inspired on the T- Cell model of the immune system is presented, it is used to solve Economic Dispatch Problems with smooth objective function.
Victoria S. Aragón, Susana Cecilia Esquivel   +1 more
doaj  

Depletion of Mitochondrial Cyclophilin D in Endothelial and Smooth Muscle Cells Attenuates Vascular Dysfunction and Hypertension

Function
Hypertension is a major risk factor of cardiovascular disease affecting nearly half of adult population. It is associated with mitochondrial dysfunction and understanding these mechanisms is important to develop new therapies.
Anna Dikalova, Mingfang Ao, Louise Lantier, Sergey Gutor, Sergey Dikalov   +4 more
doaj   +1 more source

Desipramine, commonly used as a noradrenergic neuroprotectant in 6-OHDA-lesions, leads to local functional changes in the urinary bladder and gastrointestinal tract in healthy rats

Heliyon, 2020
The 6-hydroxydopamine (6-OHDA) rat model is one of the most common animal models of Parkinson's disease. When experimentally inducing dopaminergic neurodegeneration in the nigrostriatal pathway using 6-OHDA, the noradrenergic reuptake inhibitor ...
Maria del Pilar Murillo, Patrik Aronsson, Michael Winder, Thomas Carlsson   +3 more
doaj   +1 more source