Results 61 to 70 of about 5,439,443 (343)

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Phase structure of intrinsic curvature models on dynamically triangulated disk with fixed boundary length

, 2006
A first-order phase transition is found in two types of intrinsic curvature models defined on dynamically triangulated surfaces of disk topology. The intrinsic curvature energy is included in the Hamiltonian.
Ambjorn, Anagnostopoulos, Baillie, Baillie, Baillie, Borelli, Borelli, Bowick, Bowick, Bowick, Bowick, Catterall, Cooke, David, Endo, Gennes, Goetz, Gompper, H. Koibuchi, Helfrich, Igawa, Kantor, Kantor, Kleinert, Kleinert, Koibuchi, Koibuchi, Koibuchi, Koibuchi, Koibuchi, Koibuchi, Koibuchi, Koibuchi, Koibuchi, Kownacki, Noguchi, Noguchi, Peliti, Pinnow, Polyakov, Wheater, Wheater   +41 more
core   +2 more sources

First-order phase transition of the tethered membrane model on spherical surfaces [PDF]

, 2005
We found that three types of tethered surface model undergo a first-order phase transition between the smooth and the crumpled phase. The first and the third are discrete models of Helfrich, Polyakov, and Kleinert, and the second is that of Nambu and ...
Ambjorn, Ambjorn, Anagnostopoulos, Borelli, Borelli, Bowick, Bowick, Bowick, Bowick, Bowick, Bowick, Catterall, David, David, David, David, Duplantier, Green, Gross, Helfrich, Hiroshi Koibuchi, Igawa, Isao Endo, Jurkiewicz, Kantor, Kantor, Kleinert, Koibuchi, Koibuchi, Koibuchi, Koibuchi, Koibuchi, Koibuchi, Koibuchi, Koibuchi, Koibuchi, Koibuchi, Koibuchi, Kownacki, Lee, Matsumoto, Nelson, Nelson, Paczuski, Peliti, Polyakov, Wheater, Wheater, Wiese   +48 more
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

DDX3X induces mesenchymal transition of endothelial cells by disrupting BMPR2 signaling

FEBS Open Bio, EarlyView.
Elevated DDX3X expression led to downregulation of BMPR2, a key regulator of endothelial homeostasis and function. Our co‐immunoprecipitation assays further demonstrated a molecular interaction between DDX3X and BMPR2. Notably, DDX3X promoted lysosomal degradation of BMPR2, thereby impairing its downstream signaling and facilitating endothelial‐to ...
Yu Zhang, Jing Wang, De‐Hui Qian, Yang‐Fan Lv, Tian‐Le Cheng, Da‐Peng Wang, Jing Zhang, Ye Fan   +7 more
wiley   +1 more source

Panel Smooth Transition Regression Models [PDF]

We develop a non-dynamic panel smooth transition regression model with fixed individual effects. The model is useful for describing heterogenous panels, with regression coefficients that vary across individuals and over time. Heterogeneity is allowed for
Andres Gonzalez, Dick van Dijk, Timo Terasvirta   +2 more
core   +3 more sources

Liquid-Gas Phase Transition in Nuclear Equation of State [PDF]

, 1997
A canonical ensemble model is used to describe a caloric curve of nuclear liquid-gas phase transition. Allowing a discontinuity in the freeze out density from one spinodal density to another for a given initial temperature, the nuclear liquid-gas phase ...
A. Z. Mekjian, J. A. Hauger, J. Pochodzalla, M. L. Gilkes, S. J. Lee, S. J. Lee, X. Campi   +6 more
core   +3 more sources

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source