Results 141 to 150 of about 7,787 (254)

Targeting EZH2 in Cancer: From Molecular Mechanisms to Clinical Translation

MedComm – Oncology, Volume 5, Issue 2, June 2026.
The abnormal overexpression or gain‐of‐function mutations of EZH2 play a significant role in cancer occurrence and progression, highlighting the importance and potential of EZH2 as a cancer biomarker. Therefore, screening for effective and safe small‐molecule inhibitors, degraders, and natural compounds targeting EZH2 through preclinical cancer models ...
Xi Zhong, Jieni Li, Mingxuan Pan, Xiaoxue Ke, Hongjuan Cui   +4 more
wiley   +1 more source

RRS Discovery Cruise 346, 05 Jan - 19 Feb 2010. The 2010 transatlantic hydrography section at 24.5°N

, 2012
A Hydrographic section was occupied at a nominal latitude of 24.5°N in the Atlantic Ocean during January - February 2010 on Cruise 346 of RRS Discovery.
King, B.A.
core  

Oncofetal Biology: From Fundamental Mechanisms to Emerging Therapeutic Opportunities

MedComm – Oncology, Volume 5, Issue 2, June 2026.
Oncofetal biology provides a transformative framework for understanding cancer initiation, progression, and therapeutic intervention. This review synthesizes the core molecular mechanisms connecting embryonic development and tumorigenesis from a multidisciplinary standpoint and outlines future research trajectories and clinical applications, and we aim
Yang Liu, Kaifeng Niu, Qingran Kong, Shaorong Gao   +3 more
wiley   +1 more source

When invasions go unnoticed: Public perception of the freshwater jellyfish Craspedacusta sowerbii in Europe

People and Nature, Volume 8, Issue 6, Page 1957-1973, June 2026.
Abstract Biological invasions are a major driver of biodiversity loss, yet inconspicuous or “cryptic” species often escape detection and public awareness, limiting management responses. We investigated the freshwater jellyfish Craspedacusta sowerbii, likely native to China and now present on six continents, through a 22‐month multilingual online survey
Guillaume Marchessaux, Kristína Slovák Švolíková, Barbora Števove, Ali Serhan Tarkan, Daniela Giannetto, Cristina Preda, Belma Kalamujić Stroil, Maciej K. Mańko, András Abonyi, Álmos Becz, Massimo Morpurgo, Evgeny A. Pakhomov, Levan Mumladze, Mar Bosch‐Belmar, Aino Hosia, Patricia Ventura, Jamileh Javidpour, Florian Lüskow   +17 more
wiley   +1 more source

Harnessing Phytochemicals for Brain Cancer Therapy: Insights Into Medulloblastoma and Glioblastoma Treatment

Phytochemical Analysis, Volume 37, Issue 4, Page 507-535, June 2026.
ABSTRACT Primary brain tumors are life‐threatening diseases. Glioblastoma is the most aggressive type with a poor prognosis. Medulloblastoma is the most common pediatric brain tumor. While surgical treatments often result in recurrences owing to the complex nature of the tumor microenvironment, conventional treatments lower the quality of life of ...
Ilkay Irem Ozbek, Mesra Aktas, Hale Saybasili, Kutlu O. Ulgen   +3 more
wiley   +1 more source

A Top‐Down View of Global and Regional Carbon Budgets From an Ensemble of Atmospheric Inversions

Global Biogeochemical Cycles, Volume 40, Issue 6, June 2026.
Abstract Atmospheric inversions provide surface CO2 flux estimates based on in situ observed atmospheric CO2 mole fractions or satellite‐based column average CO2 (XCO2). Here, we provide a detailed assessment of 14 atmospheric CO2 inversions included in the Global Carbon Budget (GCB2024).
A. M. van der Woude, I. T. Luijkx, R. J. de Kok, W. Peters, F. Chevallier, C. Rödenbeck, P. Ciais, N. Chandra, K. Wang, R. Janardanan, H. van Asperen, A. Bastos, A. van den Berg, A. A. Bloom, S. Botía, K. Bowman, J. G. Canadell, R. A. F. de Souza, C. Q. Dias‐Junior, L. Feng, P. Friedlingstein, L. V. Gatti, E. Gloor, K. Ishijima, F. Jiang, Z. Jin, W. Ju, X. Lan, J. Liu, Z. Liu, T. Machida, S. Maksyutov, A. C. Manning, A. Martinez, G. A. Martins, K. McKain, J. B. Miller, L. Nayagam, Y. Niwa, P. I. Palmer, P. K. Patra, P. A. Pickers, B. Poulter, B. B. Stephens, C. Sweeney, S. Wofsy, Z. Wu, D. Yang, J. Yun, N. Zeng   +49 more
wiley   +1 more source

Dynamics off the Congo River and Its Impact on the Water Exchange Between the Coastal and Open Ocean at Different Timescales

Journal of Geophysical Research: Oceans, Volume 131, Issue 6, June 2026.
Abstract The Congo River represents one of the largest freshwater discharges in the Atlantic Ocean. In this study, we investigate the role of mesoscale and submesoscale dynamics in modulating salinity transport, using a 3 km‐resolution realistic numerical simulation.
C. Cardot, I. Dadou, D. C. Napolitano, H. M. A. Aguedjou, R. Ngakala, Y. Morel, G. Morvan, G. Alory, C. Le Goff, G. Jan, J. Jouanno   +10 more
wiley   +1 more source

History Matching of Soil Moisture and Evapotranspiration Over Europe Using Iterative Ensemble Smoothers

Journal of Advances in Modeling Earth Systems, Volume 18, Issue 6, June 2026.
Abstract Land surface models are crucial components within earth system models, simulating the exchanges of water, energy, carbon, and nitrogen between the land surface, atmosphere, and subsurface. One challenge is the large number of uncertain parameters in these models.
Mikael L. A. Kaandorp, Haojin Zhao, Christian Poppe Terán, Carl Hartick, Paul Rigor, Harrie‐Jan Hendricks Franssen   +5 more
wiley   +1 more source

SMOS: ESA's water mission

, 2013
Martech 2009 Third Marine Technology Workshop, 19-20 november 2009, Vilanova i la Geltrú, Barcelona.-- 1 pageESA’s Water Mission, otherwise known as the Soil Moisture and Ocean Salinity Mission (SMOS) was selected as the second Earth Explorer opportunity
Riera, Tecla, Ros, Joandomènec, Estrada, Marta, Miracles, R. M., Vallespinós, Ferrán, Font, Jordi, Torres, Francesc   +6 more
core  

Reciprocal Regulation of GLI1 and GLI3 Fine Tunes the Pathogenic Behavior of Synovial Fibroblasts in Rheumatoid Arthritis

International Journal of Rheumatic Diseases, Volume 29, Issue 6, June 2026.
ABSTRACT Objective We investigated the role of GLI3, a transcription factor highly expressed in the pathogenic THY1+CD34− sublining subset of rheumatoid arthritis synovial fibroblasts (RASFs), in regulating their pathogenic behavior. Methods GLI3 protein levels were quantified in freshly isolated RASF subsets by Western blotting.
Motohiko Sato, Tetsuya Saito, Yoji Komiya, Seiji Noda, Yasuhiro Tagawa, Akio Yamamoto, Hideyuki Iwai, Kentaro Endo, Hideyuki Koga, Yasuhiro Takahara, Kazutaka Sugimoto, Ichiro Sekiya, Eiryo Kawakami, Tadashi Hosoya, Shinsuke Yasuda   +14 more
wiley   +1 more source