Results 41 to 50 of about 5,110,471 (293)

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

SMS for Life : a pilot project to improve anti-malarial drug supply management in rural Tanzania using standard technology [PDF]

, 2010
Background: Maintaining adequate supplies of anti-malarial medicines at the health facility level in rural sub-Saharan Africa is a major barrier to effective management of the disease.
Jim, B., Seif Kungulwe, Ward Peter, Wereko-Brobby Olympia, Olympia Wereko-Brobby, Mwafongo, Winfred, Ward, Peter M., Olympia, W.B., Barrington, Jim, Jim Barrington, Kungulwe, Seif, Winfred, M., Winfred Mwafongo, Mwafongo Winfred, Seif, K., Kungulwe Seif, Peter Ward, Peter, W., Wereko-Brobby, Olympia, Barrington Jim   +19 more
core   +2 more sources

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

The integrated role of Safety Management Systems (SMS) and risk management in achieving aviation sustainability

Discover Sustainability
The aviation industry faces ongoing operational risks, regulatory challenges, and sustainability pressures, necessitating the adoption of Safety Management Systems (SMS) as a structured framework for enhancing safety performance and long-term resilience.
Hani Al-Dmour, Hazim AlKhawaldeh, Ahmed Al-Dmour, Bader Obidat, Rand Al-Dmour   +4 more
doaj   +1 more source

Plugging the Gap between Safety Documents and Workers Perception, to Prevent Accidents at Seveso Establishments

Chemical Engineering Transactions, 2012
At “Seveso” establishments, Safety Report SR and Safety Management System SMS have been mandatory for many years. At most small and medium size enterprises, the complex documents underlying SR and SMS are managed by specialists, which are very far from ...
P. Agnello, S. Ansaldi, P. Bragatto
doaj   +1 more source

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

Molecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira, Ana Teixeira‐Marques, Rui Freitas, João A Carvalho, Sara Monteiro‐Reis, Giorgio I. Russo, Rui Henrique, Carmen Jerónimo   +7 more
wiley   +1 more source

Safety management system and hazards in the aircraft maintenance industry: a systematic literature review

Aviation, 2023
In the last decade, the aircraft maintenance industry has experienced a paradigm shift in safety management. This is primarily due to the implementation of Safety Management Systems (SMS) in its business practices.
Alok Tyagi, Rajesh Tripathi, Soufiane Bouarfa   +2 more
doaj   +1 more source

Using SMS text messaging for teaching and data collection in the behavioral sciences [PDF]

, 2009
Recent interest in university teaching has focused on interactivity in lectures and practical classes, and teachers in several fields have set up systems in which students can interact with the lecturer using mobile-phone-based SMS text messaging.
Stewart, N., Stewart, Neil, Reimers, S.J., Reimers, Stian   +3 more
core   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source