Results 161 to 170 of about 2,596,182 (387)

A Phase 1, Randomized, Placebo‐Controlled, Multiple‐Dose, Double‐Blind Study to Evaluate and Compare the Pharmacokinetics and Safety of Rimegepant in Healthy Adult Japanese and Caucasian Individuals

open access: yesClinical Pharmacology in Drug Development, EarlyView.
Abstract This Phase 1, randomized, placebo‐controlled, double‐blind study assessed the pharmacokinetic profile of rimegepant (25, 75, or 150 mg once daily for 14 days) in healthy Japanese and Caucasian adults. Exposures were modestly increased in Japanese participants compared with Caucasian participants following a single dose of rimegepant (Day 1 ...
Rajinder Bhardwaj   +6 more
wiley   +1 more source

Repeated Intake of Grapefruit Juice Inhibits CYP2B6, CYP2C9, CYP2C19, and CYP3A4 while Lingonberry Powder Does Not Induce Major CYP Enzymes in Humans

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Grapefruit juice is a well‐established inhibitor of cytochrome P450 (CYP) 3A4, but its effects on other CYP enzymes or organic anion transporting polypeptides (OATPs) are not fully characterized in humans. Recently, lingonberry powder was shown to induce murine CYP enzymes. We investigated the effects of lingonberry powder and grapefruit juice on seven
Laura Aurinsalo   +7 more
wiley   +1 more source

The backdoor to overconsumption: the effect of associating 'light' food with health. [PDF]

open access: yes
Marketers present compromise food products (e.g. light chips) as a way to reduce consumers' conflict between the short-term desire of wanting a snack and the long-term goal of a healthy body.
Dewitte, Siegfried   +3 more
core  

Straight to Phase III: Model‐Informed Approach Speeds Depemokimab Clinical Development in Interleukin‐5‐Driven Diseases

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Straight to Phase III: Model‐informed approach speeds depemokimab clinical development in interleukin‐5‐driven diseases. IL‐5, a key mediator of type 2 inflammation, underlies various diseases, including severe asthma, CRSwNP, EGPA, and HES. Reduction in blood eosinophil count (BEC), a biomarker of IL‐5 activity, is commonly used to evaluate the ...
Chiara Zecchin   +6 more
wiley   +1 more source

Dietary assessment in intermittent fasting: validation of a short food frequency questionnaire vs. food records in diurnal dry fasting and time-restricted eating

open access: yesFrontiers in Nutrition
ObjectivesFood frequency questionnaire (FFQ) is a cost-effective method of dietary assessment in nutritional and clinical research. It can be easily adapted to different research questions or populations, but modified versions require careful validation.
Isabelle C. Schüssler   +16 more
doaj   +1 more source

Expansion and functional properties of extruded snacks enriched with nutrition sources from food processing by-products [PDF]

open access: bronze, 2015
Sopida Korkerd   +4 more
openalex   +1 more source

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