Results 111 to 120 of about 299,181 (381)

Discovery of Natural Compound α‐Hederin via Large‐Scale Screening as a Targeted JAK/STAT3 Inhibitor for Ovarian Cancer Therapy

Advanced Science, EarlyView.
This study identifies α‐Hederin as a potent dual JAK1/JAK2 inhibitor that blocks STAT3 activation in ovarian cancer. By disrupting STAT3‐driven transcriptional programs, α‐Hederin suppresses tumor proliferation, invasion, and EMT, while enhancing cisplatin efficacy and overcoming chemoresistance.
Jiayu Wang, Pengzhan He, Cheng Liu, Xin Chen, Yilin Tan, Rui Qu, Yan Zhang, Zhou Li, Tailang Yin, Zhinang Yin   +9 more
wiley   +1 more source

Diversity and Damage Assessment of Snail in Cultivated Crops of Neelabut Bagh Azad Jammu and Kashmir (Pakistan)

Journal of Bioresource Management, 2020
The present study was conducted to study diversity and damage assessment of snails in cultivated crops and ornamental plants. The study revealed two types of snail species Macrochlamys indica and Indoplanorbis exustus in the study area. The sampled plots
Abu ul hassan faiz , Lariab Zahra Faiz
doaj   +1 more source

The lncRNA HOTAIR transcription is controlled by HNF4α-induced chromatin topology modulation [PDF]

, 2018
The expression of the long noncoding RNA HOTAIR (HOX Transcript Antisense Intergenic RNA) is largely deregulated in epithelial cancers and positively correlates with poor prognosis and progression of hepatocellular carcinoma and gastrointestinal cancers.
A Busanello, AL Cattin, AM Cozzolino, C Battistelli, C Battistelli, C Battistelli, C Cicchini, C Cicchini, C Cicchini, C Padua Alves, Carla Cicchini, Cecilia Battistelli, Claudia Montaldo, DW Dodd, E Bolotin, F Garibaldi, F Parviz, Frank J. Gonzalez, Giovanna Sabarese, H Hagege, J Dekker, JA Bonzo, JL Rinn, K Kim, L Amicone, L Santangelo, Laura Santangelo, M Darsigny, MA Battle, Marco Tripodi, MC Tsai, MJ Milevskiy, N Skrypek, NL Lazarevich, R Kogo, RA Gupta, RE Hewitt, S Holwerda, S Satohisa, S Sekiya, SH Ahn, T Oshima, WD Garrison, Y Kamiyama, Y Nie, Y Qiao, Y Ren, YJ Geng, Z Chen, Z Yang, ZH Wu, ZQ Wu   +51 more
core   +1 more source

CircPVT1 Promotes Lung Metastasis and Tumor Progression in Renal Cell Carcinoma by Encoding the cP104aa Peptide and Targeting EIF4A3

Advanced Science, EarlyView.
This study reveals that circPVT1 promotes the renal cell carcinoma lung metastasis and tumor progression through encoding the cP104aa peptide and directly binds with EIF4A3, which jointly regulates the target gene c‐MYC. Abstract Circular RNA (circRNA) plays a pivotal role in the pathogenesis of renal cell carcinoma (RCC).
Houliang Zhang, Tao Tao, Jie Ji, Tonglei Zhao, Si Sun, Lijie Zhang, Jianping Wu, Ming Chen, Shuqiu Chen, Bin Xu, Weipu Mao   +10 more
wiley   +1 more source

Helix pomatia endobrônquico. Aspiração de um corpo estranho muito pouco frequente. Endobronchial Helix pomatia. A very rare foreign-body aspiration

Revista Portuguesa de Pneumologia, 2008
A aspiração de corpos estranhos é uma entidade frequente em crianças, mas rara em adultos. Os autores apresentam o caso de um adulto de 57 anos, sem comprometimento neurológico, que aspirou um caracol-das-vinhas (Helix pomatia) durante uma refeição ...
A. Santos Costa, Abel Afonso
doaj  

Snail reprograms glucose metabolism by repressing phosphofructokinase PFKP allowing cancer cell survival under metabolic stress

Nature Communications, 2017
Dynamic regulation of glucose flux between aerobic glycolysis and the pentose phosphate pathway (PPP) during epithelial–mesenchymal transition (EMT) is not well-understood.
N. Kim, Y. Cha, Jueun Lee, Seon-Hyeong Lee, Ji Hye Yang, Jun Seop Yun, E. Cho, Xianglan Zhang, M. Nam, Nami Kim, Y. Yuk, S. Cha, Yoonmi Lee, Joo Kyung Ryu, Sunghyouk Park, J. Cheong, S. Kang, S. Kim, G. Hwang, J. Yook, Hyun Sil Kim   +20 more
semanticscholar   +1 more source

Ubiquitination‐Dependent LLGL2 Degradation Drives Colorectal Cancer Progression via THBS3 mRNA Stabilization

Advanced Science, EarlyView.
During the progression of CRC, MDM2, as an E3 ubiquitin ligase, promotes the degradation of the LLGL2 protein. Reduced expression of the LLGL2 protein leads to the loss of support for the CNOT1 protein, decreasing the degradation of THBS3 mRNA. The increased THBS3 further activates the PI3K‐Akt pathway, promoting the proliferation and metastasis of CRC.
Jiayan Huang, Tiantian Zhang, Huimin Li, Zidan Li, Shuangshuang Yin, Yiman Liu, Chunze Zhang, Yuling Qiu, Haiyang Yu   +8 more
wiley   +1 more source

Effect of zinc oxide on liveweight, reproductive organ dimensions and spermatozoa production of Archachatina marginata during dry season

Agricultura Tropica et Subtropica, 2018
Demand for Giant African Land Snail in Nigeria is so high such that it is very difficult to meet up with the supply as a protein source. However, during dry season, production at intensive level is often challenged with decline in growth and reproduction
Abiona John Adesanya, Olaoye Taiwo Gabriel, Abioja Monsuru Oladimeji, Onagbesan Okanlawon Mohammed   +3 more
doaj   +1 more source

Snail Chirality: The Unwinding [PDF]

Current Biology, 2016
Most snails are coiled clockwise, but in some species rare genetic variants with reverse coiling occur. Now, a molecular determinant of coiling direction has been identified, the cytoskeletal regulator formin.
openaire   +3 more sources

Isolation and characterization of the full-length cDNA encoding a member of a novel cytochrome p450 family (CYP320A1) from the tropical freshwater snail, Biomphalaria glabrata, intermediate host for Schistosoma mansoni [PDF]

, 2005
Cytochrome p450s (cyp450s) are a family of structurally related proteins, with diverse functions, including steroid synthesis and breakdown of toxins. This paper reports the full-length sequence of a novel cyp450 gene, the first to be isolated from the ...
Altschul SF, Anne E Lockyer, Brown DJ, Catherine S Jones, Chang GWM, Chaty S, David Rollinson, Gough J, Leslie R Noble, Lockyer AE, Madera M, Nelson DR, Nelson DR, Omura T, Sambrook J, Snyder MJ, Snyder MJ, Teunissen Y   +17 more
core   +5 more sources