Results 111 to 120 of about 215,951 (299)

Neurotoxicity of a Novel Local Anesthetic Agent, Ropivacaine: The Possible Roles of Bursts of Potential and Cytoplasmic Second Messenger

Journal of the Formosan Medical Association, 2007
Ropivacaine has been shown to induce convulsion following overdose or accidental intravenous injection, but the mechanisms are poorly understood.
Pei-Lin Lin, Shou-Zen Fan, Feng-Fong Tsai, Ming-Cheng Tsai, Chia-Hsien Lin, Chi-Hsiang Huang   +5 more
doaj   +1 more source

MUC1 as a Survival Effector of Radiotherapy‐Induced Epithelial Hybrid States in Basal‐Like Breast Cancer

International Journal of Cancer, EarlyView.
Basal‐like breast cancer (BLBC) is aggressive and often exhibits inherent or acquired resistance to radiotherapy (RT), a primary treatment option. RT resistance is underpinned by molecular alterations, many of which are poorly understood. Here, RT‐induced transcriptomic changes were analyzed using bulk and spatial sequencing in a BLBC mouse model and ...
Garyfallia Pantelaiou‐Prokaki, Husam Bamahmoud, Nadine S. Georges, Shaishavi Jansari, Annika Jung, Daniela Grimm, Evangelos Prokakis, Fabian Alexander Gayer, Maryam Deldar, Christian Dullin, Julia Gallwas, Florian Wegwitz, Frauke Alves   +12 more
wiley   +1 more source

Integration of Fish, Snail and Water Spinach With Macrobrachium rosenbergii: An Approach of Integrated Multi‐Trophic Prawn Aquaculture in Southwest Bangladesh

Aquaculture, Fish and Fisheries
This study evaluated the production performance and profitability of an integrated multi‐trophic aquaculture (IMTA) system by incorporating Indian major carp (Labeo rohita), small indigenous fish species (SIS) (Amblypharyngodon mola), snails (Pila ...
Shanchita Zaman Chowdhury, Md. Rofiqul Islam, Joyanta Bir, Shikder Saiful Islam, Abul Farah Md. Hasanuzzaman, Khandaker Anisul Huq   +5 more
doaj   +1 more source

Knockdown of long non‐coding RNA linc‐ITGB1 inhibits cancer stemness and epithelial‐mesenchymal transition by reducing the expression of Snail in non‐small cell lung cancer

Thoracic Cancer, 2019
Background The main cause of death in patients with non‐small cell lung cancer (NSCLC) is the progression of cancer metastasis, which can be attributed to multiple factors, such as cancer stem cells (CSCs) and epithelial‐mesenchymal transition (EMT ...
Lili Guo, Cencen Sun, Shilei Xu, Yue Xu, Qiuping Dong, Linlin Zhang, Wei Li, Xingyu Wang, Guoguang Ying, Fengjie Guo   +9 more
doaj   +1 more source

The Snail Lemma

Theory and Applications of Categories, 2016
The author establishes a new diagrammatic statement, which he calls the snail Lemma, and which subsumes the classical snake Lemma. To be more precise, the diagrammatic statement of the author holds in the general context of a pointed, regular and protomodular category, where we can also give a sense to the snake Lemma (see [\textit{D.
openaire   +3 more sources

N6‐Methyladenosine (m6A) in Liver Disease: Pathogenic Mechanisms and Therapeutic Potential

iNew Medicine, EarlyView.
ABSTRACT Accumulating evidence highlights the critical role of epigenetic modifications, particularly N6‐methyladenosine (m6A), in liver disease. As the most abundant RNA modification in eukaryotic cells, m6A is dynamically regulated by multicomponent m6A methyltransferases (e.g., METTL3 and METTL14), demethylases (FTO and ALKBH5), and m6A‐binding ...
Yingfen Chen, Ru Ya, Ziling Zhang, Siyue Dong, Seol Hee Park, Wonhyo Seo, Yong He   +6 more
wiley   +1 more source

SUMOylation regulates tumorigenesis and progression: Molecular mechanisms and therapeutic applications

Interdisciplinary Medicine, EarlyView.
SUMOylation, a dynamic post‐translational modification, acts as a master regulator at the heart of tumor malignancy. Our work delineates how the SUMOylation cycle—mediated by E1/E2/E3 enzymes and reversed by SENPs—orchestrates multiple hallmarks of cancer. The central pathway converges on three critical pathological axes: 1.
Yimao Wu, Zichang Chen, Yinting Hu, Gokhan Zengin, Qian Zhang, Meng‐Yao Li, Wenlong Sun   +6 more
wiley   +1 more source

Heart rate and body weight alterations in juvenile specimens of the tropical land snail Megalobulimus sanctipauli during dormancy

Brazilian Journal of Medical and Biological Research, 2001
The time course of heart rate and body weight alterations during the natural period of dormancy were determined in active feeding and dormant juvenile specimens of Megalobulimus sanctipauli.
Rizzatti A.C.S., Romero S.M.B.
doaj  

Microemulsion‐Based Drilling Fluids Incorporating Seashell Residue Powder: A Sustainable Approach to Fluid Loss Control

Journal of Surfactants and Detergents, EarlyView.
Two microemulsion‐based drilling fluids incorporating SSRP were formulated using pine oil, the nonionic surfactant Alkonat L100W, and a glycerol/water solution. The results provide valuable insights into how surfactant‐assisted microemulsion systems can be engineered to enhance the performance and eco‐efficiency of drilling fluids.
Luara Ribeiro Viana, Raphael Ribeiro da Silva, João Pedro Gonçalves de Souza Soares, José Cavalcante de Queiroz Neto, Maria Eduarda Araújo Pessoa, Rafael Peixoto Alves, Fabiola Dias da Silva Curbelo   +6 more
wiley   +1 more source

Gender and Land Degradation Neutrality (LDN): Evaluating Nigeria's Legislative Framework for Achieving Gender‐Equitable LDN Outcomes

Land Degradation &Development, EarlyView.
ABSTRACT Legislative frameworks that support gender equality are crucial for addressing structural inequalities, protecting women's rights, and achieving gender‐equitable land degradation neutrality (LDN) outcomes. This study examines the extent to which national‐level policies and legislation governing LDN and related sectors incorporate gender ...
Cynthia Nneka Olumba, Chukwudi Charles Olumba   +1 more
wiley   +1 more source